Involvement of 5‐HT<sub>3</sub>receptors in the development and expression of methamphetamine‐induced behavioral sensitization: 5‐HT<sub>3A</sub>receptor channel and binding study

Yoo, Ji-Hoon; Cho, Jae-Han; Yu, Hyun-Sook; Lee, Kwang-Wook; Lee, Byung-Hwan; Jeong, Se-Min; Nah, Seung‐Yeol; Kim, Hyoung‐Chun; Lee, Seok‐Yong; Jang, Choon‐Gon

doi:10.1111/j.1471-4159.2006.04137.x

Cited by 14 publications

(6 citation statements)

References 45 publications

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“…In contrast, SR 57227 significantly elevated vertical activity in both males and females, although no sex difference was observed. This is in accordance with literature on SR 57227, indicating that 5-HT 3 agonists have little effect on locomotor activity when administered alone (52), (23). …”

Section: Discussionsupporting

confidence: 93%

Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL/6J mice

Brookshire

Jones

2009

Pharmacology Biochemistry and Behavior

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It is well established that the dopamine (DA) and serotonin (5-HT) systems have extensive and complex interactions. However, the effects of specific 5-HT receptor agonists on traditionally DA-related behaviors remain unclear. Our goal in these studies was to characterize the effects of 5-HT receptor agonists on measures of locomotor activity and vertical rearing. The SSRIs fluoxetine and citalopram produced significant decreases in locomotor activity and vertical rearing at the highest doses used with females significant more sensitive to citalopram. The 5-HT1A agonist 8-OH-DPAT and the 5-HT2C agonist MK 212 significantly decreased activity in both male and female mice, with females more sensitive to 8-OH-DPAT. In contrast, the 5-HT1B agonist RU 24969 and the 5-HT2A agonist DOI both increased activity, with DOI exhibiting differential effects with regard to sex. Finally, the 5-HT3 agonist SR 57227 produced significant locomotor increases only in female mice at the lowest dose. The results of these experiments define locomotor profiles of several 5-HT agonists in male and female C57BL/6J mice, providing a foundation for further explorations of 5-HT receptor effects on activity.

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Section: Discussionsupporting

confidence: 93%

Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL/6J mice

Brookshire

Jones

2009

Pharmacology Biochemistry and Behavior

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“…Rats receiving single daily injections of METH, followed by multiple runs (four daily injections at 2-hr intervals) showed a decrease in serotonin response in the striatum during runs (Segal and Kuczenski 1997). The findings that pretreatment with MDL 72222, a 5-HT 3 antagonist, can attenuate both the development and expression of METH-induced behavioral sensitization (Yoo et al 2006), and repeated treatment with aripiprazole (a drug with 5-HT 1A agonist action) during the withdrawal period from repeated METH treatment attenuated METH-induced behavioral sensitization (Futamura et al 2010), also point to the notion that serotonin-mediated neurotransmission are related to the psychotomimetic effect of METH. Other neurotransmitters implicated in METH sensitization include substance P and sigma receptors, as evidenced by the findings that repeated METH treatment decreased the substance P receptor binding (Ujike et al 1988) and sigma receptor antagonist BMY 14802 prevents the development of behavioral sensitization induced by repeated administration of METH (Ujike et al 1992).…”

Section: Animal Modelsmentioning

confidence: 99%

Methamphetamine-Associated Psychosis

Grant

LeVan

Wells

et al. 2011

J Neuroimmune Pharmacol

209

137

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Methamphetamine (METH) is a frequent drug of abuse in U.S. populations and commonly associated with psychosis. This may be a factor in frequent criminal justice referrals and lengthy treatment required by METH users. Persecutory delusions and auditory hallucinations are the most consistent symptoms of METH-associated psychosis (MAP). MAP has largely been studied in Asian populations and risk factors have varied across studies. Duration, frequency and amount of use as well as sexual abuse, family history, other substance use, and co-occurring personality and mood disorders are risk factors for MAP. MAP may be unique with its long duration of psychosis and recurrence without relapse to METH. Seven candidate genes have been identified that may be associated with MAP. Six of these genes are also associated with susceptibility, symptoms, or treatment of schizophrenia and most are linked to glutamatergic neurotransmission. Animal studies of pre-pulse inhibition, attenuation of social interaction, and stereotypy and alterations in locomotion are used to study MAP in rodents. Employing various models, rodent studies have identified neuroanatomical and neurochemical changes associated with METH use. Throughout this review, we identify key gaps in our understanding of MAP and suggest potential directions for future research.

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“…Serotonin receptors (5‐HT 1A , 5‐HT 2A and 5‐HT 3 receptors) are implicated in the development and/or expression of sensitization [59–61], indicating that serotonin receptors are also therapeutic targets for the reversal of sensitization. Chronic 5‐HT 3 receptor antagonism (ondansetron) [62–66] and chronic 5‐HT 2A receptor antagonism (clozapine, mianserin, and ketanserin) [67], combined with dopamine D1/D2 receptor agonism (cocaine or pergolide), reverse sensitization.…”

Section: Effect Of Dopamine D2 or D1/d2 Receptor Agonism On Establishmentioning

confidence: 99%

Treatment of the Psychostimulant-Sensitized Animal Model of Schizophrenia

Shuto

Nishi

2010

CNS Neuroscience &Amp; Therapeutics

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Behavioral sensitization to psychostimulants in rodents is associated with the alteration of dopaminergic neurotransmission, and has been proposed as a useful model of schizophrenia due to its progressively intensifying, easily relapsing, and long-lasting features. Pharmacological treatments that reverse the established sensitization may have potential therapeutic values for schizophrenia. The present aim is to review pharmacological treatments that induce the reversal of established sensitization to psychostimulants. In addition, we discuss possible mechanisms for the reversal of sensitization. Reversal of sensitization is induced by chronic dopamine D1 receptor agonism, D2 or D1/D2 receptor agonism combined with mild N-methyl-D-aspartate (NMDA) receptor antagonism or serotonin (5-HT(2A) or 5-HT(3) ) receptor antagonism, 5-HT(1A) receptor agonism, and 5-HT(2A) or 5-HT(3) receptor antagonism. Chronic treatments with these drugs likely adjust altered dopaminergic neurotransmission in sensitized animals. Especially, chronic dopamine D1 receptor agonism, which may adjust mesolimbic hyperdopaminergic and mesocortical hypodopaminergic functions in sensitized animals, is an attractive therapeutic approach for schizophrenia.

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Involvement of 5‐HT₃receptors in the development and expression of methamphetamine‐induced behavioral sensitization: 5‐HT_3Areceptor channel and binding study

Cited by 14 publications

References 45 publications

Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL/6J mice

Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL/6J mice

Methamphetamine-Associated Psychosis

Treatment of the Psychostimulant-Sensitized Animal Model of Schizophrenia

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Involvement of 5‐HT3receptors in the development and expression of methamphetamine‐induced behavioral sensitization: 5‐HT3Areceptor channel and binding study

Cited by 14 publications

References 45 publications

Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL/6J mice

Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL/6J mice

Methamphetamine-Associated Psychosis

Treatment of the Psychostimulant-Sensitized Animal Model of Schizophrenia

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Involvement of 5‐HT₃receptors in the development and expression of methamphetamine‐induced behavioral sensitization: 5‐HT_3Areceptor channel and binding study