Involvement of a short-type peptidoglycan recognition protein (PGRP) from Chinese giant salamanders Andrias davidianus in the immune response against bacterial infection

Yang, Hui; Li, Xixi; Song, Weijia; Ji, Jiaojun; Li, Fenggang; Zhang, Yingying; Zhang, Xiaojun; Wang, Lixin

doi:10.1016/j.dci.2018.07.008

Cited by 11 publications

(2 citation statements)

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“…These recognised microbial‐specific molecules are detected by the host defence immune PRRs, and then the host defence responses are activated (Choe et al, 2005). Comparably, PAMPs can be divided into peptidoglycan (PGN), lipopolysaccharide (LPS), bacterial DNA, and so on (Yang et al, 2018). Insects recognise bacteria by sensing specific PGNs, which are necessary conserved components of bacterial cell walls by PGRPs (Yang et al, 2018; Zaidman‐Rémy et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Comparably, PAMPs can be divided into peptidoglycan (PGN), lipopolysaccharide (LPS), bacterial DNA, and so on (Yang et al, 2018). Insects recognise bacteria by sensing specific PGNs, which are necessary conserved components of bacterial cell walls by PGRPs (Yang et al, 2018; Zaidman‐Rémy et al, 2006). These different kinds of PGNs are selectively bound by PGRPs (Irina et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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A role of peptidoglycan recognition protein in mediating insecticide detoxification in Glyphodes pyloalis

Jiang

Ding

Liu

et al. 2021

Arch Insect Biochem Physiol

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Glyphodes pyloalis Walker has become one of the most significant mulberry pests, and it has caused serious economic losses in major mulberry growing regions in China. Peptidoglycan recognition proteins (PGRPs) are responsible for initiating and regulating immune signalling pathways in insects. However, their roles responding to chemical pesticides is still less known. This study aimed to investigate the possible detoxication function of GpPGRP‐S2 and GpPGRP‐S3 in G. pyloalis in response to chlorfenapyr and phoxim. The chlorfenapyr and phoxim treatment significantly induced the expression level of GpPGRP‐S3 at 48 h. In addition, the expression levels of GpPGRP‐S2 and GpPGRP‐S3 in the chlorfenapyr/phoxim treatment group were significantly higher in midgut than those in the control group at 48 h. The results of the survival experiment showed that silencing either GpPGRP‐S2 or GpPGRP‐S3 would not influence the survival rate of G. pyloalis which treated with phoxim, however, silencing GpPGRP‐S2 or GpPGRP‐S3 would cause G. pyloalis to be more easily killed by chlorfenapyr. The expression of carboxylesterase GpCXE1 was significantly induced by chlorfenapyr/phoxim treatment, while it was suppressed once silenced GpPGRP‐S2 followed with chlorfenapyr treatment or silenced GpPGRP‐S3 followed with phoxim treatment. These results might suggest that under the chlorfenapyr/phoxim treatment condition, the connection between GpPGRPs and detoxification genes in insect was induced to maintain physiological homeostasis; and these results may further enrich the mechanisms of insects challenged by insecticides.

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