2016
DOI: 10.3906/biy-1507-59
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Involvement of AMP-activated protein kinase in the protective effectof melatonin against renal ischemia reperfusion injury

Abstract: We investigated the implication of AMP-activated protein kinase (AMPK) in melatonin-induced protection in a renal ischemia/reperfusion (I/R) model. Animals were divided into four groups: rats of the sham group were not subjected to renal I/R. Rats in the I/R group received the vehicle 30 min before renal ischemia for 1 h followed by reperfusion for 6 h. Rats in the Mel+I/R group received melatonin (10 mg/kg) 30 min before the onset of I/R. Rats in the Mel+I/R+araA group received araA (AMPK inhibitor, 100 µg/kg… Show more

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“…Interestingly, it scavenges free radicals more effectively than vitamin E (40). It has been presented that melatonin as a key modulator of cell survival, greatly increases activation of AMP-activated protein kinase (AMPK) that stimulates antioxidative enzymes and contributes to antioxidant defense (41). In addition to this, melatonin therapy improved RIR injury by preventing cell apoptosis, oxidative stress and histopathological lesions in diabetic rats with RIR injury (42).…”
Section: Melatoninmentioning
confidence: 99%
“…Interestingly, it scavenges free radicals more effectively than vitamin E (40). It has been presented that melatonin as a key modulator of cell survival, greatly increases activation of AMP-activated protein kinase (AMPK) that stimulates antioxidative enzymes and contributes to antioxidant defense (41). In addition to this, melatonin therapy improved RIR injury by preventing cell apoptosis, oxidative stress and histopathological lesions in diabetic rats with RIR injury (42).…”
Section: Melatoninmentioning
confidence: 99%