Involvement of Aquaporins in the Pathogenesis, Diagnosis and Treatment of Sjögren’s Syndrome

Soyfoo, Muhammad Shahnawaz; Chivasso, Clara; Perret, Jason; Delporte, Christine

doi:10.3390/ijms19113392

Cited by 38 publications

(31 citation statements)

References 106 publications

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“…It is also possible that reduced or absent tear secretion in patients with NGLY1 is an indirect result of defective AQP-dependent eye function. Patients with Sjogren's syndrome (OMIM-270150) exhibit decreased lacrimal and salivary gland secretion as a result of defective cellular trafficking of AQP5 (Soyfoo et al, 2018;Steinfeld et al, 2001;Groneberg et al, 2001). AQP1 gene therapy restored salivary and lacrimal gland fluid secretion in a mouse model of Sjogren's syndrome (Lai et al, 2016), again linking AQPs to lacrimal gland dysfunction.…”

Section: Discussionmentioning

confidence: 98%

N-Glycanase 1 Transcriptionally Regulates Aquaporins Independent of Its Enzymatic Activity

Tambe

Freeze

2019

Cell Reports

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Section: Discussionmentioning

confidence: 98%

N-Glycanase 1 Transcriptionally Regulates Aquaporins Independent of Its Enzymatic Activity

Tambe

Freeze

2019

Cell Reports

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“…AQP1 is expressed in myoepithelial and endothelial cells of mouse SG, but not in acinar and ductal cells [ 20 , 23 ]. AQP3, AQP4 and AQP8 are located at the basal region of acinar cells and in ductal cells [ 13 , 21 , 23 ]. AQP8 is also expressed by myoepithelial cells [ 24 ].…”

Section: Cellular Distribution Of Aqps In Adult Sg Subsectionmentioning

confidence: 99%

“…Noteworthy, however, is that the unorthodox AQP11 is glycerol permeable [ 11 ]. Several AQPs are expressed by the various SG cells [ 12 , 13 ], including AQP5 that plays an important role in the mechanism of saliva secretion [ 14 , 15 , 16 ]…”

Section: Introductionmentioning

confidence: 99%

Insight into Salivary Gland Aquaporins

D’Agostino

Elkashty

Chivasso

et al. 2020

Cells

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The main role of salivary glands (SG) is the production and secretion of saliva, in which aquaporins (AQPs) play a key role by ensuring water flow. The AQPs are transmembrane channel proteins permeable to water to allow water transport across cell membranes according to osmotic gradient. This review gives an insight into SG AQPs. Indeed, it gives a summary of the expression and localization of AQPs in adult human, rat and mouse SG, as well as of their physiological role in SG function. Furthermore, the review provides a comprehensive view of the involvement of AQPs in pathological conditions affecting SG, including Sjögren’s syndrome, diabetes, agedness, head and neck cancer radiotherapy and SG cancer. These conditions are characterized by salivary hypofunction resulting in xerostomia. A specific focus is given on current and future therapeutic strategies aiming at AQPs to treat xerostomia. A deeper understanding of the AQPs involvement in molecular mechanisms of saliva secretion and diseases offered new avenues for therapeutic approaches, including drugs, gene therapy and tissue engineering. As such, AQP5 represents a potential therapeutic target in different strategies for the treatment of xerostomia.

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“…Already in 1996, AQP5 gene therapy was considered as a possible medication for salivary glands impairment [Delporte et al, 1996]. New studies suggest AQP5 gene therapy as a potential treatment in Sjögren's syndrome patients, an autoimmune systemic disease with diminished saliva and tear production [Soyfoo et al, 2018].…”

Section: Discussionmentioning

confidence: 99%

Aquaporins’ Influence on Different Dental Erosive Wear Phenotypes in Humans

et al. 2020

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Dental erosive wear is a multifactorial condition of high prevalence. Nowadays, there is an emphasis on discovering individual genetic predisposition for the development of this condition. Aquaporins (AQPs) are water channel proteins expressed in salivary glands, as well as during tooth development. They are involved in salivary secretion and composition and linked to physiological protection of the oral cavity. The aim of this study was to explore the relationship between different dental erosive wear phenotypes, AQP genes, and selected environmental factors. Data from 705 dental patients were used to investigate the association between dental erosive wear phenotypes and AQPs' single-nucleotide variants. Phenotypes were further analyzed considering diet and oral hygiene data, using logistic regression analysis, as implemented in PLINK, with the assumption that dental erosive wear is a complex gene-environment model. Associations were found between severe erosive tooth wear and rs2878771 (AQP2) for the genotypic (p = 0.02) and dominant (p = 0.03) models, and rs3736309 (AQP5) for the allelic model (p = 0.02). Logistic regression analyses, after implementing the Bonferroni correction, showed that several significant associations were present when covariates were included, suggesting that a strong environmental component is present. Our results show that dental erosive wear establishes under a gene-environmental complex model.

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Involvement of Aquaporins in the Pathogenesis, Diagnosis and Treatment of Sjögren’s Syndrome

Cited by 38 publications

References 106 publications

N-Glycanase 1 Transcriptionally Regulates Aquaporins Independent of Its Enzymatic Activity

N-Glycanase 1 Transcriptionally Regulates Aquaporins Independent of Its Enzymatic Activity

Insight into Salivary Gland Aquaporins

Aquaporins’ Influence on Different Dental Erosive Wear Phenotypes in Humans

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