Involvement of Autoantibodies to Neurotransmitters in Mechanisms of Stress Reaction in Rats

We studied the effects of intranasal administration of antiglutamate antibodies on the development of stress response and level of neurotransmitter amino acids and monoamines in brain structures of rats with different initial behavioral activity. The stress exposure was followed by significant changes in behavioral activity and concentration of neurotransmitters in rat hippocampus and hypothalamus. The changes in the level of neurotransmitter amino acids and monoamines were more pronounced in the hippocampus. Antiglutamate antibodies administered intranasally in a single dose of 250 μg/kg immediately after stress exposure prevented the development of the stress response and normalized the level of neurotransmitters in the brain structures of rats. The effect of antibodies was the most pronounced in behaviorally active rats.

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Effects of Antiglutamate Antibodies on the Development of Stress Response and Neurotransmitter Content in the Hippocampus and Hypothalamus of Rats with Different Behavioral Activity

Vetrile

Zakharova

Кудрин

et al. 2013

Bull Exp Biol Med

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Open Field Behavior and the State of the Thymus and Adrenal Glands in Rats after Exposure to Stress and Elevation of Blood Level of Autoantibodies to Dopamine and Glutamate

Umriukhin

Судаков

2013

Bull Exp Biol Med

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Blood level of autoantibodies to dopamine and glutamate in rats increased in 4 weeks after exposure to stress. Under these conditions, active animals demonstrated decreased motor and exploratory activity in the open field, while in passive animals, only the number of explored objects decreased. The increase in blood level of autoantibodies to dopamine and glutamate in rats exposed to stress was followed by an increase in the adrenal gland weight in active animals and thymus weight in passive animals. The increased blood level of autoantibodies to dopamine and glutamate in rats exposed to stress reflects the development of the long-term stress-induced response.

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Involvement of Autoantibodies to Neurotransmitters in Mechanisms of Stress Reaction in Rats

Cited by 2 publications

References 10 publications

Effects of Antiglutamate Antibodies on the Development of Stress Response and Neurotransmitter Content in the Hippocampus and Hypothalamus of Rats with Different Behavioral Activity

Effects of Antiglutamate Antibodies on the Development of Stress Response and Neurotransmitter Content in the Hippocampus and Hypothalamus of Rats with Different Behavioral Activity

Open Field Behavior and the State of the Thymus and Adrenal Glands in Rats after Exposure to Stress and Elevation of Blood Level of Autoantibodies to Dopamine and Glutamate

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