Involvement of Bone Morphogenetic Proteins (BMP) in the Regulation of Ovarian Function

Regan, Sheena L.P.; Knight, P. G.; Yovich, John L.; Leung, Yee; Arfuso, Frank; Dharmarajan, Arun

doi:10.1016/bs.vh.2018.01.015

Cited by 37 publications

(24 citation statements)

References 149 publications

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“…Moreover, BMP also participate in the regulation of the hypothalamic secretion of GnRH and ovarian sensitivity to Gns (62). These effects of BMP, particularly BMP-15, have been also seen in humans (63, 64).…”

Section: Ovarian Functioningmentioning

confidence: 87%

The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis

Devesa¹,

Caicedo

2019

Front. Endocrinol.

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Although not yet well-understood, today it is clear that Growth Hormone (GH) exerts a relevant role in the regulation of ovulation and fertility; in fact, fertility is lower in women with GH deficiency (GHD), and GH receptors (GHR) and GH mRNA have been found in the ovary since the onset of follicular development in humans. However, despite the strong evidence of GH in the regulation of fertility, many aspects of GH actions at this level are still not well-established, and it is likely that some controversial data depend on the species analyzed, the dose of the hormone and the duration of use of GH. Folliculogenesis, ovulation, and corpus luteum formation and maintenance are processes that are critically dependent on angiogenesis. In the ovary, new blood vessel formation facilitates oxygen, nutrients, and hormone substrate delivery, and also secures transfer of different hormones to targeted cells. Some growth factors and hormones overlap their actions in order to control the angiogenic process for fertility. However, we still know very little about the factors that play a critical role in the vascular changes that occur during folliculogenesis or luteal regression. To promote and maintain the production of VEGF-A in granulosa cells, the effects of local factors such as IGF-I and steroids are needed; that VEGF-A-inducing effect cannot be induced by luteinizing hormone (LH) or chorionic gonadotropin (CG) alone. As a result of the influences that GH exerts on the hypothalamic-pituitary-gonadal axis, facilitating the release of gonadotropins, and given the relationship between GH and local ovarian factors such as VEGF-A, FGF-2, IGF-1, or production of sex steroids, we assume that GH has to be a necessary factor in ovarian angiogenesis, as it happens in other vascular beds. In this review we will discuss the actions of GH in the ovary, most of them likely due to the local production of the hormone and its mediators.

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Section: Ovarian Functioningmentioning

confidence: 87%

The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis

Devesa¹,

Caicedo

2019

Front. Endocrinol.

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“…Of the differentially expressed genes, bone morphogenetic protein 2 (BMP2), bone morphogenetic protein 3 (BMP3), and BMP binding endothelial regulator (BMPER) were identified in both comparisons; BMP5 and BMP15 were detected in P-F-O1 vs. P-F-O2 only (Supplementary Table S2). The bone morphogenetic protein system plays a crucial role in ovary development and the regulation of ovarian function [37]. Bone morphogenetic protein 6 (BMP6), a regulator associated with the formation and secretion of steroid hormones, can interact with melatonin [38,39].…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiling in Ovaries and Association Analyses Reveal HEP21 as a Candidate Gene for Sexual Maturity in Chickens

Chen

Liang

Zhu

et al. 2020

Animals

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The age of onset of sexual maturity is an important reproductive trait in chickens. In this study, we explored candidate genes associated with sexual maturity and ovary development in chickens. We performed DGE RNA-sequencing analyses of ovaries of pre-laying (P-F-O1, L-F-O1) and laying (P-F-O2, L-F-O2) hens of two sub-breeds of Ningdu Yellow chicken. A total of 3197 genes were identified in the two comparisons, and 966 and 1860 genes were detected exclusively in comparisons of P-F-O1 vs. P-F-O2 and L-F-O1 vs. L-F-O2, respectively. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses showed that genes involved in transmembrane signaling receptor activity, cell adhesion, developmental processes, the neuroactive ligand–receptor interaction pathway, and the calcium signaling pathway were enriched in both comparisons. Genes on these pathways, including growth hormone (GH), integrin subunit beta 3 (ITGB3), thyroid stimulating hormone subunit beta (TSHB), prolactin (PRL), and transforming growth factor beta 3 (TGFB3), play indispensable roles in sexual maturity. As a gene unique to poultry, hen egg protein 21 kDa (HEP21) was chosen as the candidate gene. Differential expression and association analyses were performed. RNA-seq data and qPCR showed that HEP21 was significantly differentially expressed in pre-pubertal and pubertal ovaries. A total of 23 variations were detected in HEP21. Association analyses of single nucleotide polymorphisms (SNPs) in HEP21 and reproductive traits showed that rs315156783 was significantly related to comb height at 84 and 91 days. These results indicate that HEP21 is a candidate gene for sexual maturity in chickens. Our results contribute to a more comprehensive understanding of sexual maturity and reproduction in chickens.

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“…The high levels of BMP6, 4, 7 ( 25 ), and BMP15 ( 60 ) concurrently sp suppress LHR expression in granulosa cells. During the subsequent follicle section process, the FSHR and BMPR1B expression is reduced along with the BMP ligands 4, 6, 7, and 15, and this may facilitate up-regulation of granulosa cell LHR expression ( 61 ). The follicles with granulosa cells expressing LHRs are able to continue to produce estrogens, and are recruited into the dominant cohort.…”

Section: Regulation Of Bmpr1b and Fshr And Their Influence On Apoptosmentioning

confidence: 99%

Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View

et al. 2018

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Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways.

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Involvement of Bone Morphogenetic Proteins (BMP) in the Regulation of Ovarian Function

Cited by 37 publications

References 149 publications

The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis

The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis

Gene Expression Profiling in Ovaries and Association Analyses Reveal HEP21 as a Candidate Gene for Sexual Maturity in Chickens

Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View

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