Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro

Amelioration of cisplatin-induced nephrotoxicity in rats by triterpenoid saponin of Terminalia arjuna

“…A significant downregulation of renal Bcl-2 expression in cisplatin-treated rats in comparison to normal rats was reported confirming that apoptosis plays an important role in cisplatin-induced nephrotoxicity [44]. However, Arjunolic acid administration showed a significant upregulation of renal Bcl-2 expression when compared with cisplatin group indicating its antiapoptotic effect that was reported in other models as acetaminophen and cadmium-induced hepatotoxicity [26,29].…”

“…# Significant difference as compared with the cisplatin group at p \ 0.05 Clin Exp Nephrol [28]. It was reported in several studies with different models that Arjunolic acid attenuated the transcriptional activity of NF-jB [29,30,31]. Moreover, antioxidants can attenuate ROS generation and NF-jB activation and thus protect the renal cells against cisplatin injury [32].…”

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

“…These molecules can protect various organs from oxidative stress induced pathophysiology (Bhattacharyya et al, 2014;Bhattacharyya et al, 2013;Das et al, 2011Das et al, , 2012Ghosh et al, 2009Ghosh et al, , 2010Ghosh et al, , 2011Ghosh et al, , 2013Manna et al, 2007Manna et al, , 2008aManna et al, , 2008bManna et al, , 2009Manna et al, , 2012Pal et al, 2011Pal et al, , 2013Rashid et al, 2013). It is reported that ketoenol-enolate equilibrium of the heptadienone moiety of curcumin determines its physicochemical and antioxidant properties.…”

Regulation of apoptosis through bcl-2/bax proteins expression and DNA damage byZanthoxylum alatum

“…II-IV) were treated with propidium iodide (PI) and FITC-labelled Annexin V for 30 min at 37 C. Excess of PI and Annexin V were then washed off; cells were fixed and analyzed by flow cytometry using FACS Calibur (Becton Dickinson, Mountain View, CA) equipped with 488 nm argon laser light source; 515 nm band pass filter for FITC-fluorescence and 623 nm band pass filter for PIfluorescence using Cell Quest software. A scatter plot of PIfluorescence versus FITC-fluorescence has been prepared (Pal et al, 2011).…”