Involvement of brain serotonin in regulation of sexual maturity in male rats

Шишкина, Г. Т.; Бородин, П. М.

doi:10.1007/bf01190460

Cited by 3 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, the study of serotonin (5‐hydroxytryptamine; C 10 H 12 N 2 O) has gained relevance due to its importance in several biological functions. In reproduction, a major role has been proposed on the physiology of reproductive tract in males (Shishkina and Borodin, ; Campos et al, ; Frungieri et al, ; Jiménez‐Trejo et al, ; Pichardo et al, ). 5‐HT is one of the main neurotransmitters in central nervous system (CNS), and supports many cellular functions such as growth, cellular differentiation and apoptosis both in vivo and in vitro.…”

mentioning

confidence: 99%

Serotonin in Testes of Bat Myotis velifer During Annual Reproductive Cycle: Expression, Localization, and Content Variations

et al. 2013

View full text Add to dashboard Cite

The mechanism of reproduction in mammals is very complex and in some cases is quite particular. For example in some bat species, the male presents a reproductive mechanism characterized by an annual testicular cycle that goes from recrudescence to regression (spermatogenesis to inactivity period, respectively). After recrudescence, the spermatozoa arrive at epididymis and wait to be expelled at the time of ejaculation during the mating period, which occurs some months later. Because serotonin (5-HT) has gained reproductive importance in the last years, the aim of the present study was to analyze the expression of this indolamine and both tryptophan hydroxylase and monoamine oxidase isoform A-enzymes involved in its metabolism-in Myotis velifer testes, a seasonal reproductive bat species that shows temporal asynchrony in its sexual cycle, across the principal periods of their reproductive cycle. By using both Falck-Hillarp histochemistry and immunofluorescence techniques, we found serotonin in vesicles of Leydig cells and probably Sertoli cells too; interestingly, both intracellular localization and concentration was variable across the different stages of the reproductive cycle, being lower during spermatogenesis phase and increasing during the mating phase. These results suggest that 5-HT is present in bat testes and it could play an important role in testicular function during their reproductive cycle.

show abstract

mentioning

confidence: 99%

Serotonin in Testes of Bat Myotis velifer During Annual Reproductive Cycle: Expression, Localization, and Content Variations

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Although its main control is wielded by the hypothalamic–pituitary–gonadal axis (HPG axis), the fine regulation of key processes such as steroidogenesis and spermatogenesis relies on molecules that belong to other systems [ 27 , 28 ]. For this reason, it has been suggested that 5-HT could regulate, directly or indirectly, some male reproductive functions including steroidogenesis [ 29 , 30 ], spermatogenesis [ 31 , 32 , 33 ], sexual maturity in mammals [ 34 , 35 , 36 ], and urogenital pathologies in humans [ 37 , 38 ], including testis cancer [ 39 , 40 , 41 ] and infertility [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Downregulation of Serotonergic System Components in an Experimentally Induced Cryptorchidism in Rabbits

Jiménez-Trejo,

Arriaga-Canon,

Herrera

et al. 2024

IJMS

View full text Add to dashboard Cite

Cryptorchidism (CO) or undescended testes is defined as the failure of one or both testes to be positioned inside the scrotum. Typically, cryptorchidism is detected at birth or shortly thereafter, and in humans, it is considered to be part of the testicular dysgenesis syndrome (TDS), a complex pathology regarding the male reproductive system that apparently involves the interaction of both genetic and environmental harmful factors, mainly during embryonic development. Serotonin (5-HT) is an ancient molecule that participates in a broad range of body functions, and in recent years, its importance in reproduction has started to be elucidated. In male pathologies such as infertility, varicocele, erectile dysfunction, and primary carcinoid tumors, an increase in 5-HT concentration or its metabolites in the blood, semen, and urine has been directly related; nevertheless, the role of 5-HT in CO remains unknown. In the present work, our goal was to answer two important questions: (1) whether some serotonergic system components are present in adult male Oryctolagus cuniculus (chinchilla rabbit) and (2) if there are changes in their expression in an experimental model of CO. Using histological, molecular, and biochemical approaches, we found the presence of some serotonergic system components in the adult chinchilla rabbit, and we demonstrated that its expression is downregulated after CO was pharmacologically induced. Although we did not test the role of 5-HT in the etiology of CO, our results suggest that this indoleamine could be important for the regulation of steroidogenesis and spermatogenesis processes in the chinchilla rabbit during adulthood. Finally, in parallel experimental series, we found downregulation of kynurenine concentration in COI rabbits when compared to control ones, suggesting that CO could be affecting the kynurenine pathway and probably testicular immune privilege which in turn could lead to infertility/sterility conditions in this disorder.

show abstract

“…High levels of endogenous serotonin, induced by the administration of 5-hydroxytryptophan, increase FSH release in male rats at 26, 30 and 60 days of age; however, these effects are not observed at 18 and 20 days (Justo et al 1989). Furthermore, the inhibition of serotonin synthesis with p-chlorophenylalanine (PCPA) in male rats between 40 and 44 days of age decreases the endocrine function of the testis in 60-dayold animals; the same treatment in male rats between 40 and 44 days of age inhibits steroidogenesis and spermatogenesis (Shishkina & Borodin 1989). Justo et al (1989) suggested that the differential effect of serotonin on gonadotropin secretion during prepubertal development of male rats is related to the prevailing steroid milieu; other authors have made reference to this in the female rat as well.…”

Section: Introductionmentioning

confidence: 99%

Serotoninergic system blockage in the prepubertal rat inhibits spermatogenesis development

Martínez¹,

Ayala²,

Marin³

et al. 2005

Reproduction

View full text Add to dashboard Cite

The stimulatory and inhibitory role of serotonin in gonadotropin secretion and in the onset of puberty in the male rat has been previously described, but its role in the establishment of spermatogenesis is not known. The aim of this study was to investigate the effects of serotoninergic inhibition by p-chloroamphetamine (pCA) on the prepubertal-to-adult stage of the rat reproductive system. Hypothalamic serotonin, gonadotropins and sex steroid hormone concentrations were measured, and a histopathological analysis of seminiferous epithelium was carried out on animals treated with pCA from day 30 and killed at 45 or 65 days of age. The pCA treatment significantly reduced the hypothalamic levels of serotonin and its metabolite (5-hydroxyindole-3-acetic acid). This inhibition did not affect the sex steroid hormone or LH concentrations, but rather it induced an increase in FSH concentration in animals of both ages. Spermatogenesis was impaired by pCA treatment. Disruption of seminiferous epithelium and the death of numerous germ cells were observed. Sperm produced by pCA-treated animals was of poor quality and appeared in small quantities. Apparently, serotonin depletion did not affect communication between the hypothalamus and the pituitary, but the FSH increase could have been related to alterations in the seminiferous epithelium effects. The seminiferous epithelium cycle was altered in rats killed at both 45 and 65 days of age, because at each age of killing the distribution of spermatogenesis stages was different. Germ cell apoptosis did not appear to be related to changes in the FSH concentrations, but other factors produced during spermatogenesis could have been involved in this induction. This study showed that serotonin was necessary for the development of normal spermatogenesis in prepubertal rats. Reproduction (2005) 129 717-727

show abstract

Involvement of brain serotonin in regulation of sexual maturity in male rats

Cited by 3 publications

References 15 publications

Serotonin in Testes of Bat Myotis velifer During Annual Reproductive Cycle: Expression, Localization, and Content Variations

Serotonin in Testes of Bat Myotis velifer During Annual Reproductive Cycle: Expression, Localization, and Content Variations

Downregulation of Serotonergic System Components in an Experimentally Induced Cryptorchidism in Rabbits

Serotoninergic system blockage in the prepubertal rat inhibits spermatogenesis development

Contact Info

Product

Resources

About