Involvement of calmodulin-dependent protein kinase I in the regulation of the expression of connexin 43 in MA-10 tumor Leydig cells

Najih, Mustapha; Nguyen, Ha Tuyen; Martin, Luc J.

doi:10.1007/s11010-022-04553-7

Cited by 4 publications

(3 citation statements)

References 79 publications

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“…The two COUP-TF factors have not been reported to be stimulated by CAMKI, although a study showed that the activity of COUP-TFI is potentiated by the related CAMKIV in neuronal cells [ 58 ]. Our study also revealed that CAMKI CA enhances the activity of cJUN on the Star promoter both in MA-10 and in CV-1 cells, similar what was recently reported on the Cx43 promoter in MA-10 Leydig cells [ 59 ]. We observed a strong stimulation of the activity of CREB by CAMKI CA on the Star promoter.…”

Section: Discussionsupporting

confidence: 90%

Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells

Pierre

Tremblay

2022

IJMS

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Hormone-induced Leydig cell steroidogenesis requires rapid changes in gene expression in response to various hormones, cytokines, and growth factors. These proteins act by binding to their receptors on the surface of Leydig cells leading to activation of multiple intracellular signaling cascades, downstream of which are several kinases, including protein kinase A (PKA), Ca2+/calmodulin-dependent protein kinase I (CAMKI), and extracellular signal-regulated protein kinase 1 and 2 (ERK1/2). These kinases participate in hormone-induced steroidogenesis by phosphorylating numerous proteins including transcription factors leading to increased steroidogenic gene expression. How these various kinases and transcription factors come together to appropriately induce steroidogenic gene expression in response to specific stimuli remains poorly understood. In the present work, we compared the effect of PKA, CAMKI and ERK1/2 on the transactivation potential of 15 transcription factors belonging to 5 distinct families on the activity of the Star gene promoter. We not only validated known cooperation between kinases and transcription factors, but we also identified novel cooperations that have not yet been before reported. Some transcription factors were found to respond to all three kinases, whereas others were only activated by one specific kinase. Differential responses were also observed within a family of transcription factors. The diverse response to kinases provides flexibility to ensure proper genomic response of steroidogenic cells to different stimuli.

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Section: Discussionsupporting

confidence: 90%

Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells

Pierre

Tremblay

2022

IJMS

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“…Different types of connexins are encoded by a class of genes including five groups ( Gja , Gjb , Gjc , Gjd and Gje ), each composed of several members and isoforms. Leydig cells express mainly Gja1 (CX43), and to a lesser extent Gja4 (CX37), Gja6 (CX33), Gjc1 (CX45), Gjc2 (CX47), Gjd2 (CX36), and Gjd3 (CX31.9/30.2) [ 220 , 221 , 222 , 223 ]. Only the inactivation of GJA1 has been characterized for its effects on steroidogenesis and does not appear to be critical for Leydig cell development, differentiation and function [ 224 , 225 ].…”

Section: Bzip Transcription Factors and Leydig Cell Communicationmentioning

confidence: 99%

“…In addition, AP-1 members may be functionally redundant as JUN, JUNB and FOSL2 also efficiently increased Gja1 promoter activity in TM3 Leydig cells [ 234 ]. With significant endogenous levels in Leydig cells [ 223 , 235 ], FOS or FOSL2 can interact with JUN, JUNB or JUND to regulate Gja1 expression. Thus, AP-1 dimers binding to the Gja1 promoter may consist of FOS/JUN, FOS/JUNB, FOS/JUND, FOSL2/JUN, FOSL2/JUNB or FOSL2/JUND in mouse Leydig cells.…”

Section: Bzip Transcription Factors and Leydig Cell Communicationmentioning

confidence: 99%

Basic Leucine Zipper Transcription Factors as Important Regulators of Leydig Cells’ Functions

Martin

Nguyen

2022

IJMS

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Transcription factors members of the basic leucine zipper (bZIP) class play important roles in the regulation of genes and functions in testicular Leydig cells. Many of these factors, such as cAMP responsive element binding protein 1 (CREB1) and CCAAT enhancer binding protein beta (CEBPB), are regulated by the cAMP/protein kinase A (PKA) pathway, the main signaling pathway activated following the activation of the luteinizing hormone/choriogonadotropin membrane receptor LHCGR by the - hormone LH. Others, such as X-box binding protein 1 (XBP1) and members of the cAMP responsive element binding protein 3 (CREB3)-like superfamily, are implicated in the endoplasmic reticulum stress by regulating the unfolded protein response. In this review, the influences of bZIP transcription factors, including CREB1, CEBPB and activator protein 1 (AP-1) family members, on the regulation of genes important for cell proliferation, steroidogenesis and Leydig cell communication will be covered. In addition, unresolved questions regarding the mechanisms of actions of bZIP members in gene regulation will be identified.

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Vitamin D, Calbindin, and calcium signaling: Unraveling the Alzheimer's connection

Acharya,

Singh,

Gupta

et al. 2024

Cellular Signalling

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Involvement of calmodulin-dependent protein kinase I in the regulation of the expression of connexin 43 in MA-10 tumor Leydig cells

Cited by 4 publications

References 79 publications

Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells

Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells

Basic Leucine Zipper Transcription Factors as Important Regulators of Leydig Cells’ Functions

Vitamin D, Calbindin, and calcium signaling: Unraveling the Alzheimer's connection

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