Involvement of cAMP-Dependent Protein Kinase in the Nucleus Accumbens in Cocaine Versus Social Interaction Reward

Amaral, Inês M.; Lemos, Cristina; Cera, Isabella; Dechant, Georg; Hofer, Alex; Rawas, Rana El

doi:10.3390/ijms22010345

Cited by 9 publications

(14 citation statements)

References 44 publications

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“…In rodents, social interaction was found to be rewarding [ 23 ]. When available as an alternative to drugs, dyadic social interaction reduced cocaine preference [ 24 , 25 , 26 , 27 , 28 ] ( Figure 1 ) and prevented cocaine-induced reinstatement of cocaine preference [ 24 ]. Interestingly, the dyadic social interaction episodes did not result in the development of an observable hierarchy or a dominance/subordination rank [ 29 , 30 ].…”

Section: Social Rank and Drugs Of Abusementioning

confidence: 99%

“…However, we focus on dyadic social interaction available in an alternative context to drugs. This form of interaction with an age- and weight-matched conspecific was shown to consistently abolish the preference to drugs [ 24 , 25 , 26 ], thereby allowing effective coping to build resilience against drug abuse [ 15 ].…”

Section: Social Rank and Drugs Of Abusementioning

confidence: 99%

“…On the test day, when the doors to the stimulus-associated compartments are open and the animal is given the choice of where to spend more time, it will spend a similar amount of time in the cocaine-associated, and in the social interaction-associated, compartment. Social interaction reward and cocaine reward have an equal reward value [ 25 , 26 ]. Right panel: time rats subjected to a concurrent CPP protocol spent in each compartment during the test.…”

Section: Figurementioning

confidence: 99%

“…Right panel: time rats subjected to a concurrent CPP protocol spent in each compartment during the test. n = 8, Unpaired T-test, t(14) = 0.9666, p = 0.3501 (n.s) [ 26 ].…”

Section: Figurementioning

confidence: 99%

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Is It Possible to Shift from Down to Top Rank? A Focus on the Mesolimbic Dopaminergic System and Cocaine Abuse

2021

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Impaired social behavior is a common feature of many psychiatric disorders, in particular with substance abuse disorders. Switching the preference of the substance-dependent individual toward social interaction activities remains one of the major challenges in drug dependence therapy. However, social interactions yield to the emergence of social ranking. In this review, we provide an overview of the studies that examined how social status can influence the dopaminergic mesolimbic system and how drug-seeking behavior is affected. Generally, social dominance is associated with an increase in dopamine D2/3 receptor binding in the striatum and a reduced behavioral response to drugs of abuse. However, it is not clear whether higher D2 receptor availability is a result of increased D2 receptor density and/or reduced dopamine release in the striatum. Here, we discuss the possibility of a potential shift from down to top rank via manipulation of the mesolimbic system. Identifying the neurobiology underlying a potential rank switch to a resilient phenotype is of particular interest in order to promote a positive coping behavior toward long-term abstinence from drugs of abuse and a protection against relapse to drugs. Such a shift may contribute to a more successful therapeutic approach to cocaine addiction.

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Section: Social Rank and Drugs Of Abusementioning

confidence: 99%

Section: Social Rank and Drugs Of Abusementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

“…Right panel: time rats subjected to a concurrent CPP protocol spent in each compartment during the test. n = 8, Unpaired T-test, t(14) = 0.9666, p = 0.3501 (n.s) [ 26 ].…”

Section: Figurementioning

confidence: 99%

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Is It Possible to Shift from Down to Top Rank? A Focus on the Mesolimbic Dopaminergic System and Cocaine Abuse

2021

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“…When rats were self-administering cocaine in an addicted-like way, operant social interaction inhibited cocaine self-administration and prevented the incubation of cocaine seeking [ 16 ]. Moreover, in a conditioned place preference paradigm (CPP), the presence of a social partner to interact with, in the compartment opposite to the one associated with cocaine, abolished cocaine preference during conditioning [ 17 , 18 , 19 , 20 ] after the conditioning to cocaine was already established [ 21 ], and during extinction of cocaine preference [ 17 , 22 , 23 ]. Thus, rewarding social interaction, when available in an alternative context, could shift the preference away from drugs of abuse.…”

Section: Introductionmentioning

confidence: 99%

Rewarding Social Interaction in Rats Increases CaMKII in the Nucleus Accumbens

et al. 2021

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Calcium/calmodulin-dependent protein kinase II (CaMKII) is known to be involved in the sensitized locomotor responses and drug-seeking behavior to psychostimulants. However, little is known about the contribution of CaMKII signaling in the nucleus accumbens (NAc) in natural rewards such as social interaction. The present experiments explored the implication of CaMKII signaling in drug versus natural reward. In the NAc of rats expressing cocaine or social interaction conditioned place preference (CPP), αCaMKII activation was induced in those expressing social interaction but not cocaine CPP. In order to investigate the role of NAc CaMKII in the expression of reward-related learning of drug versus non-drug stimuli, we inhibited CaMKII through an infusion of KN-93, a CaMKII inhibitor, directly into the NAc shell or core, before the CPP test in a concurrent paradigm in which social interaction was made available in the compartment alternative to the one associated with cocaine during conditioning. Whereas vehicle infusions led to equal preference to both stimuli, inhibition of CaMKII by a KN-93 infusion before the CPP test in the shell but not the core of the NAc shifted the rats’ preference toward the cocaine-associated compartment. Altogether, these results suggest that social interaction reward engages CaMKII in the NAc.

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Expression Quantitative Trait Locus rs6356 Is Associated with Susceptibility to Heroin Addiction by Potentially Influencing TH Gene Expression in the Hippocampus and Nucleus Accumbens

Wang

Zhang

et al. 2022

J Mol Neurosci

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Opioid addiction is a complicated and highly heritable brain disease. Dysfunction of dopaminergic signaling is involved in the pathogenesis of addictive disorders. Encoding the synthetase of dopamine, tyrosine hydroxylase (TH) gene has long been an interesting candidate in the genetic association studies for opioid addiction. However, the underlying mechanism of the association of risk gene variants and opioid addiction remains unknown. In the present study, we rst analyzed the association between TH gene variants and susceptibility and traits of heroin addiction in 801 patients with heroin addiction and 930 healthy controls. The methylation level in the promoter region of the TH gene was detected and compared between the heroin addiction and healthy control groups. To reveal the potential mechanism of the association of TH gene variants and heroin addiction, correlation between the risk TH SNPs for heroin addiction and the methylation as well expression level of TH gene were examined. Our results demonstrated that SNP rs6356 was associated with the susceptibility of heroin addiction. CpG TH_15 was hypermethylated in the heroin addiction group compared with the healthy control group. Notably, SNP rs6356 was allele-speci c correlated with the expression of TH gene in the hippocampus and nucleus accumbens, but not the methylation level of CpG TH_15. Our ndings suggest that the eQTL rs6356 was associated with the risk of heroin addiction by potentially affecting the expression of TH gene in the mesocorticolimbic dopamine system brain regions including hippocampus and nucleus accumbens.

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Involvement of cAMP-Dependent Protein Kinase in the Nucleus Accumbens in Cocaine Versus Social Interaction Reward

Cited by 9 publications

References 44 publications

Is It Possible to Shift from Down to Top Rank? A Focus on the Mesolimbic Dopaminergic System and Cocaine Abuse

Is It Possible to Shift from Down to Top Rank? A Focus on the Mesolimbic Dopaminergic System and Cocaine Abuse

Rewarding Social Interaction in Rats Increases CaMKII in the Nucleus Accumbens

Expression Quantitative Trait Locus rs6356 Is Associated with Susceptibility to Heroin Addiction by Potentially Influencing TH Gene Expression in the Hippocampus and Nucleus Accumbens

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