Involvement of cholinergic nicotinic receptors in the menthol-induced gastric relaxation

Amato, Antonella; Serio, Rosa; Mulè, Flavia

doi:10.1016/j.ejphar.2014.10.012

Cited by 19 publications

(14 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Functional interaction between nicotinic receptors and menthol has been reported earlier both in vitro and in vivo investigations (Dessirier et al, 2001; Ruskin et al, 2008; Willis et al, 2011; Hans et al, 2012; Ashoor et al, 2013a; Amato et al, 2014b). In an earlier study, it was found that menthol significantly reduces sensory perception and irritation caused by nicotine (Dessirier et al, 2001) and by inhalation of cigarette smoke (Willis et al, 2011).…”

Section: Effects Of Menthol On Ion Channelsmentioning

confidence: 72%

“…The co-application of hexamethonium and phentholamine, α-adrenergic receptor antagonist or hexamethonium and atropine, muscarinic receptor antagonist, did not cause any additive decrease of the menthol-induced relaxation. In this study, authors concluded that the interaction between nAChR and menthol is likely to be an important stage for menthol-induced relaxation of gastric muscle (Amato et al, 2014b). …”

Section: Effects Of Menthol On Ion Channelsmentioning

confidence: 79%

“…In addition to these findings, nicotine-induced decreases in body temperature, as a result of cutaneous vasodilation, are reduced considerably following the administration of both acute and chronic menthol (Ruskin et al, 2008). In a recent investigation, the extent of gastric relaxation induced by menthol was considerably decreased in the presence of hexamethonium, a nAChR blocker (Amato et al, 2014b). Menthol, at concentrations that did not alter gastric tone, decreased the contraction caused by nAChR agonist, dimethylphenylpiperazinium.…”

Section: Effects Of Menthol On Ion Channelsmentioning

confidence: 97%

See 2 more Smart Citations

Cellular and Molecular Targets of Menthol Actions

et al. 2017

View full text Add to dashboard Cite

Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Recently, there has been renewed awareness in comprehending the biological and pharmacological effects of menthol. TRP channels have been demonstrated to mediate the cooling actions of menthol. There has been new evidence demonstrating that menthol can significantly influence the functional characteristics of a number of different kinds of ligand and voltage-gated ion channels, indicating that at least some of the biological and pharmacological effects of menthol can be mediated by alterations in cellular excitability. In this article, we examine the results of earlier studies on the actions of menthol with voltage and ligand-gated ion channels.

show abstract

Section: Effects Of Menthol On Ion Channelsmentioning

confidence: 72%

Section: Effects Of Menthol On Ion Channelsmentioning

confidence: 79%

Section: Effects Of Menthol On Ion Channelsmentioning

confidence: 97%

See 1 more Smart Citation

Cellular and Molecular Targets of Menthol Actions

et al. 2017

View full text Add to dashboard Cite

show abstract

“…P23XL; Grass Medical Instruments, Quincy, MA, USA). The stomach mechanical activity was monitored as changes of endoluminal pressure and recorded on ink‐writer polygraph (Grass model7D; Grass Instruments), as previously described . Spontaneous small rhythmic contractions and basal tone developed in all preparations.…”

Section: Methodsmentioning

confidence: 99%

“…28,33,34 Therefore, the purpose of this study was to verify possible peripheral effects of the exogenous peptide on the mouse gastric mechanical activity, using an in vitro experimental approach, which allows to record the basal tone of the stomach, without the use of contractile agents, as previously described. 35,36 In addition, the influence of PP on mouse gastric emptying in vivo was analyzed and the genic expression of Y4 receptor was verified.…”

mentioning

confidence: 99%

Pancreatic polypeptide stimulates mouse gastric motor activity through peripheral neural mechanisms

Amato

Baldassano

Caldara

et al. 2016

Neurogastroenterology Motil

View full text Add to dashboard Cite

show abstract

Ligand‐stereoselective allosteric activation of cold‐sensing TRPM8 channels by an H‐bonded homochiral menthol dimer with head‐to‐head or head‐to‐tail

Wang

2021

Chirality

View full text Add to dashboard Cite

Both menthol and its analog WS-12 share the same hydrophobic intra-subunit binding pocket between a voltage-sensor-like domain and a TRP domain in a cold-sensing TRPM8 channel. However, unlike WS-12, menthol upregulates TRPM8 with a low efficacy but a high coefficient of a dose response at membrane hyperpolarization and with ligand stereoselectivity at membrane depolarization. The underlying mechanisms are unknown. Here, this in silico research suggested that the ligand-stereoselective sequential cooperativity between two menthol molecules in the WS-12 pocket is required for allosteric activation of TRPM8. Furthermore, two H-bonded homochiral menthol dimers with both head-to-head and head-to-tail can compete for the WS-12 site via non-covalent interactions. Although both dimers can form an H-bonding network with a voltage sensor S4 to disrupt a S3-S4 salt bridge in the voltage-sensor-like domain to release a "parking brake," only one dimer may drive channel opening by pushing a "gas pedal" in the TRP domain away from the S6 gate against S4. In this way, the efficacy is decreased, but the cooperativity is increased for the menthol effect at membrane hyperpolarization. Therefore, this review may extend a new pathway for ligand-stereoselective allosteric regulation of other voltage-and ligand-gated ion channels by menthol.

show abstract

Involvement of cholinergic nicotinic receptors in the menthol-induced gastric relaxation

Cited by 19 publications

References 39 publications

Cellular and Molecular Targets of Menthol Actions

Cellular and Molecular Targets of Menthol Actions

Pancreatic polypeptide stimulates mouse gastric motor activity through peripheral neural mechanisms

Ligand‐stereoselective allosteric activation of cold‐sensing TRPM8 channels by an H‐bonded homochiral menthol dimer with head‐to‐head or head‐to‐tail

Contact Info

Product

Resources

About