Involvement of circulating inflammatory factors in prognosis and risk of cardiovascular disease

Haybar, Habib; Shokuhian, Mohammad; Bagheri, Marziye; Davari, Nader; Saki, Najmaldin

doi:10.1016/j.yjmcc.2019.05.010

Cited by 32 publications

(23 citation statements)

References 140 publications

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“…The endothelial cells with inflammatory phenotype cause inflammation in the blood vessels, resulting in endothelial dysfunction and following progression of cardiovascular diseases (Sun et al, 2016). In accordance with this notion, endothelial cell inflammation is directly responsible for various cardiovascular diseases, such as hypertension, atherosclerosis, aging, stroke, heart disease, diabetes, obesity, venous thrombosis, and intimal hyperplasia (Sun et al, 2017;Castro-Ferreira et al, 2018;Haybar et al, 2019;Zhong et al, 2019).…”

Section: Introductionmentioning

confidence: 95%

Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide

et al. 2020

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Endothelial cells are important constituents of blood vessels that play critical roles in cardiovascular homeostasis by regulating blood fluidity and fibrinolysis, vascular tone, angiogenesis, monocyte/leukocyte adhesion, and platelet aggregation. The normal vascular endothelium is taken as a gatekeeper of cardiovascular health, whereas abnormality of vascular endothelium is a major contributor to a plethora of cardiovascular ailments, such as atherosclerosis, aging, hypertension, obesity, and diabetes. Endothelial dysfunction is characterized by imbalanced vasodilation and vasoconstriction, elevated reactive oxygen species (ROS), and proinflammatory factors, as well as deficiency of nitric oxide (NO) bioavailability. The occurrence of endothelial dysfunction disrupts the endothelial barrier permeability that is a part of inflammatory response in the development of cardiovascular diseases. As such, abrogation of endothelial cell activation/inflammation is of clinical relevance. Recently, hydrogen sulfide (H 2 S), an entry as a gasotransmitter, exerts diverse biological effects through acting on various targeted signaling pathways. Within the cardiovascular system, the formation of H 2 S is detected in smooth muscle cells, vascular endothelial cells, and cardiomyocytes. Disrupted H 2 S bioavailability is postulated to be a new indicator for endothelial cell inflammation and its associated endothelial dysfunction. In this review, we will summarize recent advances about the roles of H 2 S in endothelial cell homeostasis, especially under pathological conditions, and discuss its putative therapeutic applications in endothelial inflammation-associated cardiovascular disorders.

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Section: Introductionmentioning

confidence: 95%

Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide

et al. 2020

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“…Cardiovascular disease (CVD), including hypertension, atherosclerosis, cardiomyopathy and heart failure, is a leading cause of high morbidity and mortality, producing immense health and economic burdens globally (Mozaffarian, et al , ). Inflammation, dyslipidaemia and diabetes mellitus are common pathological processes and risk factors, both of which can affect the initiation and progression of CVD (Zoungas, et al , ; Haybar, et al , ). Other widely known CVD risk factors include obesity, insulin resistance and unhealthy lifestyle choices, such as smoking, lack of exercise and poor dietary habits (GBD, ; Mozaffarian, et al , ).…”

Section: Introductionmentioning

confidence: 99%

The gut microbiota and its interactions with cardiovascular disease

Wang

Feng

et al. 2020

Microbial Biotechnology

128

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Summary The intestine is colonized by a considerable community of microorganisms that cohabits within the host and plays a critical role in maintaining host homeostasis. Recently, accumulating evidence has revealed that the gut microbial ecology plays a pivotal role in the occurrence and development of cardiovascular disease (CVD). Moreover, the effects of imbalances in microbe–host interactions on homeostasis can lead to the progression of CVD. Alterations in the composition of gut flora and disruptions in gut microbial metabolism are implicated in the pathogenesis of CVD. Furthermore, the gut microbiota functions like an endocrine organ that produces bioactive metabolites, including trimethylamine/trimethylamine N‐oxide, short‐chain fatty acids and bile acids, which are also involved in host health and disease via numerous pathways. Thus, the gut microbiota and its metabolic pathways have attracted growing attention as a therapeutic target for CVD treatment. The fundamental purpose of this review was to summarize recent studies that have illustrated the complex interactions between the gut microbiota, their metabolites and the development of common CVD, as well as the effects of gut dysbiosis on CVD risk factors. Moreover, we systematically discuss the normal physiology of gut microbiota and potential therapeutic strategies targeting gut microbiota to prevent and treat CVD.

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“…Approximately 26 million patients are diagnosed with heart failure, and over 39 billion dollars is spent annually in heart failure-related treatments [4]. Common pathological processes and risk factors include inflammation, dyslipidemia, and diabetes; meanwhile, all of these risk factors will affect the initiation and progression of CHD [5,6]. Moreover, some other risk factors like insulin resistance, obesity, and unhealthy lifestyle such as lack of exercise, poor dietary habits, and smoking have relevance to CHD [7].…”

Section: Introductionmentioning

confidence: 99%

Study on the Correlation among Sleep Quality, Cognitive Function, and Self-Management Ability in Hospitalized Elderly Patients with Coronary Heart Disease

Shen

Chen

Cai

et al. 2021

Journal of Nanomaterials

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Background. Coronary heart disease (CHD) is the leading cause of death worldwide. The incidence of cardiovascular disease is especially common in low-level and middle-income countries. With the increase in the number of patients with CHD and the complexity of treatment on patients with CHD, many hospitals are devoted to developing new models of care and management for patients with CHD. Understanding the unique characteristics of the patient’s condition, including factors related to self-management, cognitive function, and sleep quality, will lead to a substantial reduction in cardiovascular disease and related mortality. Objective. To investigate the correlation among sleep quality, cognitive function, and self-management ability in hospitalized elderly patients with coronary heart disease (CHD). Methods. 120 hospitalized elderly patients with coronary heart disease (CHD) were investigated by using a self-designed general data questionnaire, Pittsburgh Sleep Quality Index (PSQI), Montreal Cognitive Function Assessment (MoCA) scale, and Coronary Heart Disease Self-management Behavior Scale (CSMS). Results. The Spearman analysis showed that sleep quality was positively correlated with cognitive function in hospitalized elderly CHD patients ( P < 0.05 ). Sleep quality was positively correlated with self-management ability in CHD patients ( P < 0.05 ). Conclusion. Improving the cognitive function and self-management ability of elderly patients with coronary heart disease can improve their sleep quality.

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Involvement of circulating inflammatory factors in prognosis and risk of cardiovascular disease

Cited by 32 publications

References 140 publications

Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide

Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide

The gut microbiota and its interactions with cardiovascular disease

Study on the Correlation among Sleep Quality, Cognitive Function, and Self-Management Ability in Hospitalized Elderly Patients with Coronary Heart Disease

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