2020
DOI: 10.1007/s00280-020-04181-2
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Involvement of cytochrome P450 enzymes in inflammation and cancer: a review

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Cited by 76 publications
(48 citation statements)
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“…Moreover, the hypomethylation levels were higher in stable MHO. CYP2E1 belongs to the superfamily of enzymes, cytochrome P450 (CYP), whose members are involved in the biotransformation of drugs, xenobiotics and endogenous substances [ 32 ]. The increased activity of CYP2E1 may promote oxidative stress due to its ability to produce excessive reactive oxygen species [ 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the hypomethylation levels were higher in stable MHO. CYP2E1 belongs to the superfamily of enzymes, cytochrome P450 (CYP), whose members are involved in the biotransformation of drugs, xenobiotics and endogenous substances [ 32 ]. The increased activity of CYP2E1 may promote oxidative stress due to its ability to produce excessive reactive oxygen species [ 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…A second realm of strong biomedical interest is the role of CYPs in the metabolism of antitumor agents. CYPs have been detected in tumors, as well as cancer cells and cell lines [ 19 , 20 ]. Most antitumor agents that exert antitumor efficacy in cancer cells have been observed to be metabolized by the CYP1, CYP2, and CYP3 family, such as flavonoids by CYP1b1, tamoxifen by CYP2D6, docetaxel and cyclophosphamide by CYP3A4/5, thalidomide by CYP2C9 and CYP2C19, and paclitaxel by CYP2C8 [ 21 , 22 ].…”
Section: Human Cypsmentioning
confidence: 99%
“…Hepatotoxicity sign caused by chemical is important in human health and drug industry and this acute liver damage sign is resulting by increasing level of specific enzyme [13,14]. M showed the lowest acute liver damage probability while AI was the highest with 0.85 Table (4) and Figure (6).…”
Section: Resultsmentioning
confidence: 99%