Involvement of cytochrome P450 monooxygenases in the response of mosquito larvae to dietary plant xenobiotics

David, Jean‐Philippe; Boyer, Sébastien; Mesneau, Agnès; Ball, Amanda; Ranson, Hilary; Dauphin‐Villemant, Chantal

doi:10.1016/j.ibmb.2006.02.004

Cited by 55 publications

(43 citation statements)

References 49 publications

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“…Although cytochrome P450 monooxygenase constitute a multigenic super family of enzymes, the ECOD activity measured using microplate tests, was viewed as a convenient measure of general P450 activity. Elevated ECOD activity has been associated with pyrethroid resistance in individual measurements on Cydia pomonella (L.) (Sauphanor et al 1997), Aedes aegypti (L.) (Brengues et al 2003, David et al 2006, and Pediculus humanus capitis (De Geer) (González Audino et al 2004). The esterase detoxiÞ-cation mechanism of pyrethroid resistance was significantly more active in two of the Argentinean deltamethrin-resistant populations, but the highly resistant Bolivian population has markedly less of this activity than CIPEIN.…”

Section: Discussionmentioning

confidence: 99%

Relative Contribution of Monooxygenase and Esterase to Pyrethroid Resistance in Triatoma infestans (Hemiptera: Reduviidae) from Argentina and Bolivia

Santo-Orihuela

Vassena

Zerba

et al. 2008

Journal of Medical Entomology

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Recently, high resistance to pyrethroid insecticides has been associated with ineffective Þeld treatments against Triatoma infestans (Klug) (Hemiptera: Reduviidae) in northern Argentina. Samples were collected from two areas in Argentina (Salta and La Rioja) and one are in Bolivia (Yacuiba), and they were subjected to toxicological and biochemical assays. All populations were resistant to deltamethrin, but they showed different proÞles to nonpyrethroid insecticides. The Salta population showed high resistance ratios (RRs) to deltamethrin and only slight differences in the susceptibility to fenitrothion and Þpronil compared with the reference strain. Otherwise, the La Rioja population showed a lower RR to deltamethrin and no resistance to fenitrothion or Þpronil. Finally, the Yacuiba population had high a RR to deltamethrin, but it was susceptibility to fenitrothion and Þpronil. In several cases, deltamethrin-resistant populations had higher susceptibility to bendiocarb than the reference strain. Measured activity of P450 monooxygenase in individual insects (based on ethoxycoumarine-O-deethylase), tended to be higher in the deltamethrin-resistant populations, but the differences were not statistically signiÞcant. Activity of speciÞc esterases determined by the hydrolysis of 7-coumaryl permethrate demonstrated an increase in the percentage of insects with higher esterase activity in the Salta and La Rioja populations. Unexpectedly, the Yacuiba population showed lower pyrethroid esterase activity than the reference strain. The different pyrethroid resistance patterns found in T. infestans from three geographical regions within Argentina and in Bolivia suggests that enzyme-based pyrethroid resistance in this species has multiple origins. Nevertheless, because nerve insensitivity (related to the presence of the kdr gene) is also an important mechanism related to pyrethroid resistance, further studies on the kdr gene should be carried to clarify the relative contribution of each pyrethroid-associated mechanism in deltamethrin-resistant populations of T. infestans.

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Section: Discussionmentioning

confidence: 99%

Relative Contribution of Monooxygenase and Esterase to Pyrethroid Resistance in Triatoma infestans (Hemiptera: Reduviidae) from Argentina and Bolivia

Santo-Orihuela

Vassena

Zerba

et al. 2008

Journal of Medical Entomology

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“…Second, many plant toxins are lipophilic, and larger fat bodies can absorb the toxins and reduce the concentration at target sites (Geyer et al 1993). Finally, key detoxification enzymes such as P450 monooxygenases are concentrated in fat bodies, at least in insects (Petersen et al 2001;David et al 2006). If tolerance of plant defences declines with energy reserves, there could be important consequences for host choice behaviour and for life history strategies.…”

Section: Introductionmentioning

confidence: 99%

Condition-dependent tolerance of monoterpenes in an insect herbivore

Reid

Purcell

2011

Arthropod-Plant Interactions

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The ability of a herbivore to tolerate plant defensive chemicals may vary with the herbivore's energetic state. We investigated the effect of body condition on the survivorship of individual mountain pine beetles, Dendroctonus ponderosae, exposed to host monoterpenes at concentrations comparable to constitutive and induced levels of defence using fumigant exposure. Body condition index was calculated as the residual mass after fitting the relationship between fresh weight and body size. Differences in survivorship among the four monoterpenes tested (a-pinene, myrcene, terpinolene and limonene) were small. Beetles with a higher body condition index survived high monoterpene concentrations better than those in poorer condition. There was no direct effect of sex, but positive effects of body size and fat content on survivorship favoured females, the sex that pioneers attacks on live trees. Higher body condition index corresponded to both higher fat content and fat-free body mass; the same conclusions about monoterpene identity and size-dependent or energy-dependent tolerance of high monoterpene concentrations held if fat or fat-free body mass were used in place of body condition index. This study highlights the need to consider insect body condition in understanding insectplant interactions.

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“…Another instance occurs in Helicoverpa zea, the cotton bollworm; CYP6B8 is induced by xanthotoxin and the enzyme metabolizes the toxin (Li et al, 2003). In addition, several reports have suggested that some of insect P450s of the CYP4, CYP9, CYP28, and CYP6 families are induced by host plants, or participate in the detoxifi cation of the host-plant allelochemicals (Danielson et al, 1997David et al, 2006;Fogleman et al, 1998;Niu et al, 2008;Snyder et al, 1995;Stevens et al, 2000;Yang et al, 2007;Zhou et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Characterization and Induction of Two Cytochrome P450 Genes, CYP6AE28 and CYP6AE30, in Cnaphalocrocis medinalis: Possible Involvement in Metabolism of Rice Allelochemicals

Liu

Yang

2010

Zeitschrift Für Naturforschung C

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Two cDNAs specific for P450 genes, CYP6AE28 and CYP6AE30, have been isolated from the rice leaf folder Cnaphalocrocis medinalis Guenée (Lepidoptera: Pyralidae). Both cDNApredicted proteins have 504 amino acid residues in length, but with molecular masses of 60177 Dalton for CYP6AE28 and 60020 Dalton for CYP6AE30, and theoretical pI values of 8.49 for CYP6AE28 and 8.56 for CYP6AE30, respectively. Both putative proteins contain the conserved structural and functional domains characteristic of all CYP6 members. CYP6AE28 and CYP6AE30 show 52% amino acid identity to each other; both of them have 49 - 56% identities with CYP6AE1, Cyp6ae12, and CYP6AE14. Phylogenetic analysis showed that the two P450s are grouped in the lineage containing some of the CYP6AE members, CYP6B P450s and CYP321A1. The transcripts of CYP6AE28 and CYP6AE30 were found to be induced in response to TKM-6, a rice variety with high resistance to C. medinalis. The results suggest that the two P450s may play important roles in adaptation to the host plant rice. This is the first report of P450 genes cloned in C. medinalis

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Involvement of cytochrome P450 monooxygenases in the response of mosquito larvae to dietary plant xenobiotics

Cited by 55 publications

References 49 publications

Relative Contribution of Monooxygenase and Esterase to Pyrethroid Resistance in Triatoma infestans (Hemiptera: Reduviidae) from Argentina and Bolivia

Relative Contribution of Monooxygenase and Esterase to Pyrethroid Resistance in Triatoma infestans (Hemiptera: Reduviidae) from Argentina and Bolivia

Condition-dependent tolerance of monoterpenes in an insect herbivore

Characterization and Induction of Two Cytochrome P450 Genes, CYP6AE28 and CYP6AE30, in Cnaphalocrocis medinalis: Possible Involvement in Metabolism of Rice Allelochemicals

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