“…Alterations in Ca 2+ handling are a cue for cardiac remodeling during disease. The connection between Ca 2+ and cardiomyocyte growth-hypertrophy associated with disease-was first uncovered by examining the responses of neonatal cardiomyocytes to altered frequency of electrical stimulation (McDonough et al 1994;Tavi et al 2004). In vivo, tachypacing or catecholamine infusion is also sufficient to elicit a hypertrophic response (Kubalova et al 2005).…”
Section: Ca 2+ Triggering Of Hypertrophic Remodelingmentioning
“…Alterations in Ca 2+ handling are a cue for cardiac remodeling during disease. The connection between Ca 2+ and cardiomyocyte growth-hypertrophy associated with disease-was first uncovered by examining the responses of neonatal cardiomyocytes to altered frequency of electrical stimulation (McDonough et al 1994;Tavi et al 2004). In vivo, tachypacing or catecholamine infusion is also sufficient to elicit a hypertrophic response (Kubalova et al 2005).…”
Section: Ca 2+ Triggering Of Hypertrophic Remodelingmentioning
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