1999
DOI: 10.3109/15419069909034396
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Involvement of Desmoplakin Phosphorylation in the Regulation of Desmosomes by Protein Kinase C, in HeLa Cells

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Cited by 19 publications
(12 citation statements)
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“…Indeed, in epithelial cells, PKCs appear to be involved in the regulation of adherens junctions via phosphorylation of vinculin (40), and of tight junctions (41), possibly due to translocation of ZO-1 and phosphorylation of occludin (42,43). In addition, PKCs have also been shown to regulate desmosomal junctions in HeLa cells (44). Thus, it is tempting to speculate that ICAM-1-coupled PKC activation may lead to interendothelial junction opening and, therefore, may contribute to leukocyte diapedesis.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, in epithelial cells, PKCs appear to be involved in the regulation of adherens junctions via phosphorylation of vinculin (40), and of tight junctions (41), possibly due to translocation of ZO-1 and phosphorylation of occludin (42,43). In addition, PKCs have also been shown to regulate desmosomal junctions in HeLa cells (44). Thus, it is tempting to speculate that ICAM-1-coupled PKC activation may lead to interendothelial junction opening and, therefore, may contribute to leukocyte diapedesis.…”
Section: Discussionmentioning
confidence: 99%
“…Both muscarinic and nicotinic antagonists have been shown to widen the intercellular spaces in epidermis and cause overt acantholysis in vitro through the mechanism that may involve alterations of both production and phosphorylation of keratinocyte adhesion molecules (reviewed in [55]). It is well known that phosphorylation of adhesion molecules plays an important role in assembly/disassembly of intercellular junctions [199-203], and that phosphorylation of cadherin [204-206], γ-catenin [207], desmoplakin [208,209], and Dsg [210-212] is associated with a loss of adhesion.…”
Section: Molecular Mechanisms Of Keratinocyte Detachment In Pemphigusmentioning
confidence: 99%
“…This clearly suggests that serine phosphorylation by PKCa is involved in the regulation of desmosomal assembly and disassembly; however, the targets that are phosphorylated by PKCa and whether they are desmosomal components has to be unraveled. There is good evidence that DP is phosphorylated by PKC, leading to almost complete solubilization of DP in HeLa cells [98]. Phosphorylation of the DP C-terminus by PKA was shown to disrupt the interaction with keratin IFs [99].…”
Section: Regulation Of Desmosomal Adhesivenessmentioning
confidence: 99%