Involvement of endogenous epinephrine in histamine-induced hyperinsulinemia and hypoglycemia in rats treated with islet-activating protein

Yajima, Motoyuki; Kurokawa, Shigeki; Yakahashi, Isamu

doi:10.1016/0006-2952(81)90603-1

Cited by 9 publications

(2 citation statements)

References 20 publications

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“…Moreover, Yajima et al (1981) have shown that injection of histamine produces marked hyperinsulinaemia in rats treated with pertussis toxin, as observed in the present work for B. pertussis infection in mice. It is thus reasonable to conclude that the effects of B. pertussis infection are mediated by pertussis toxin, although an additional contribution from lipopolysaccharide (Hewlett, Roberts, Wolff & Manclark, 1983) cannot be excluded.…”

Section: Hyperinsulinaemiasupporting

confidence: 70%

“…In the present work we have shown that several different agents can produce marked acute and transient hyperinsulinaemia in mice infected with B. pertussis. Anoxia, histamine or 2-deoxyglucose, like ether, have been shown or inferred to release catecholamines from the adrenal medulla (Yajima, Kurokawa & Takahashi, 1981;Young et al 1984). The marked hyperinsulinaemia in response to these agents in mice infected with B. pertussis could then be explained by reversal induced by B. pertussis of the inhibitory effects of adrenaline on insulin secre¬ tion as demonstrated previously for pertussis vaccine (Gulbenkian et al 1968) or infection (Furman et al 1981).…”

Section: Hyperinsulinaemiamentioning

confidence: 97%

See 1 more Smart Citation

Hypoglycaemia and acute stress-induced hyperinsulinaemia in mice infected with Bordetella pertussis or treated with pertussis toxin

Sidey¹,

Wardlaw²,

Furman³

1987

Journal of Endocrinology

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Intranasal infection of mice with a sublethal dose of Bordetella pertussis produced hypoglycaemia and hyperinsulinaemia. Exposure to ether vapour did not modify serum insulin concentrations in control mice, but produced a marked transient hyperinsulinaemia in mice infected with B. pertussis. A similar hyperinsulinaemia in infected, but not control, mice was also seen after a brief (10-15 s) period of anoxia (produced by exposure to an atmosphere of 100% N2 or 100% CO2), or following the injection of histamine or 2-deoxyglucose. Exposure to cold (2-4 degrees C) or hypoxia (8% O2 in 92% N2), however, did not alter serum concentrations of insulin in control or infected mice. The hyperinsulinaemic response to ether stress observed in mice infected with B. pertussis was abolished by pretreatment with alloxan. The hyperglycaemic effects of histamine and 2-deoxyglucose were attenuated or abolished in mice infected with B. pertussis. However, none of the stimuli which produced hyperinsulinaemia in the infected mice resulted in any further lowering of the blood glucose concentration. Pretreatment of mice with pertussis toxin (150 ng/mouse, i.v.) produced hypoglycaemia similar in magnitude to that found in animals infected with B. pertussis. Moreover, exposure of mice treated with pertussis toxin to ether vapour produced marked hyperinsulinaemia. It is suggested that the metabolic alterations seen in animals infected with B. pertussis may be mediated by pertussis toxin.

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Section: Hyperinsulinaemiasupporting

confidence: 70%