2011
DOI: 10.3892/or.2011.1247
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Involvement of endoplasmic reticulum stress in adenosine-induced human hepatoma HepG2 cell apoptosis

Abstract: Abstract. endoplasmic reticulum stress (ers)-mediated cell apoptosis has been implicated in the development of multiple diseases such as cancer, neurodegenerative diseases and ischemic reperfusion damage. previous studies have demonstrated the adenosine-induced apoptosis in several tumor cell lines. However, the role of ers in adenosine-induced human hepatoma Hepg2 cell apoptosis remains unclear. the present study was designed to determine whether ers is involved in adenosine-induced Hepg2 cell apoptosis. the … Show more

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Cited by 6 publications
(9 citation statements)
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“…In our previous study, adenosine induces ER stress and NF-κB activation [7,9,26]. In this study, we show that adenosine up-regulates the expressions of Bak and Bax and causes cell accumulation in the G0/G1 phase and apoptosis (Figures 2 and 7).…”
Section: Resultssupporting
confidence: 63%
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“…In our previous study, adenosine induces ER stress and NF-κB activation [7,9,26]. In this study, we show that adenosine up-regulates the expressions of Bak and Bax and causes cell accumulation in the G0/G1 phase and apoptosis (Figures 2 and 7).…”
Section: Resultssupporting
confidence: 63%
“…In the present study, we show a recombinant RNAi adenoviral vector (Ad-shGRP78) encoding a GFP78-targeting shRNA, decreases GFP78 mRNA levels to 24.5% and 19.3% at 100 and 200 MOI in 293A cells (Figure 1A). Our previous studies show adenosine induces HepG2 and EC109 cell apoptosis by ER stress and upregulates GRP78 expression [7,9]. Because GRP78 protects tumor cells and endows them with increased chemoresistance, downregulation of GRP78 may become an important adjunct in future anti-tumor therapy.…”
Section: Resultsmentioning
confidence: 99%
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“…Adenosine and their analogues can interfere with the synthesis of nucleic acids and exert genotoxic activity by incorporating with and altering the DNA or RNA macromolecules, which makes them exciting candidates for anticancer therapy (12)(13)(14). Although MEG3 plays a role in inhibiting tumor growth, no data are available on its function under genotoxic stress-induced apoptosis.…”
Section: Introductionmentioning
confidence: 99%