Involvement of endorphins in emotional hyperthermia of rats

Bläsig, J; Höllt, Volker; Bäuerle, Ursual; Herz, A.

doi:10.1016/0024-3205(78)90179-0

Cited by 134 publications

(23 citation statements)

References 21 publications

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“…Blasig and colleagues found an increase in T b after transportation of rats (from indoors to outdoors and back) (Blasig et al 1978). In addition, transportation of rats between buildings has a great impact on gonadotropin-releasing hormone and follicle-stimulating hormone levels (Bieglmayer et al 1980).…”

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confidence: 99%

Stress-induced hyperthermia in the rat: comparison of classical and novel recording methods

Dallmann

Steinlechner²,

Hörsten

et al. 2006

Lab Anim

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SummaryStress causes a rise in body temperature in laboratory animals (stress-induced hyperthermia). However, the direct effect of common stressors in animal research, i.e. transportation between holding and test rooms or isolation of animals, on body temperature has not been investigated to its full extent. To address this question, it is important to have a reliable and simple monitoring technique, which does not induce stress itself. In the present study, we investigated stress-related changes in body temperature of F344/Hw rats after (1) moving the cage within the holding room, (2) moving the cage from the holding room to another test room and (3) social deprivation (isolation). A combination of two different body temperature recording methods was used to clarify their accuracy and stress-inductive character: rectal temperature recording and peritoneal implanted temperature sensors (Thermochron iButtons).The results demonstrate that (1) different stressors induce a significant rise in body temperature, (2) which is detectable for more than 60 min and (3) it is of importance to standardize temperature recording methods in order to avoid confounding effects of the recording method itself. Furthermore, Thermochron iButtons are more accurate and reliable for body temperature studies than rectal recordings.

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confidence: 99%

Stress-induced hyperthermia in the rat: comparison of classical and novel recording methods

Dallmann

Steinlechner²,

Hörsten

et al. 2006

Lab Anim

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“…2) previously has been reported (6) and suggests that naloxone sensitive receptors may be involved. Others have found /3-END-induced hyperthermia to be resistant (19) or partially resis-tant (20) to naloxone antagonism.…”

Section: Resultsmentioning

confidence: 79%

Adrenal and Thyroid Interactions of -Endorphin-Induced Body Temperature Responses of Rats at 24.5 C

Gwosdow

Besch

1985

Experimental Biology and Medicine

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The effect of @-endorphin (P-END) and the role of the adrenal and thyroid glands on body temperature were examined in male rats in a controlled environment room at 24.5 k 0.1OC. Relative humidity of 50 ? 0.3% and a 12L:12D photoperiod (L = 0900 to 2100 hr) were maintained. Rectal temperature (T,) was measured using thermistors. Corticosterone and thyroid hormones were determined by radioimmunoassay. Intracerebroventricular (IVT) administration of varying doses (0.05 to 50.0 pg) of P-END resulted in a hyperthermia that began 30 min post-IVT injection and continued for an additional hour. Intravenous injections of the same doses of &END resulted in little or no T, response. The (3-END-induced hyperthermia was antagonized by intraperitoneal injection of naloxone. Pretreatment with propranolol, phenotolamine, or both drugs in combination did not block the hyperthermia caused by P-END. Adrenalectomized or hypophysectomized rats receiving IVT injections of (3-END did not consistently display an increased T,. @-Endorphin administration had no detectable effect on Serum corticosterone or thyroxine but serum triiodothyronine was decreased. These data suggest the acute hyperthermic action of 8-END is mediated centrally through Opiate receptors and does not involve adrenergic receptors. 0 1985 Society for Expenmental Blolog) andMedicine.

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“…While is unclear whether inactivation of endogenous opioid system has a similar inhibiting effect on central activational processes associated with other reinforcing stimuli, it seems likely because naloxone also attenuated body core hyperthermic responses associated with different arousing stimuli (Blasig et al, 1978; Stewart and Eikelboom, 1981) and inhibited different types of motivated behavior established by positive and negative reinforcers (Bolles and Fanselow, 1982; Holloway et al, 2004; Kim et al, 1997; Kiyatkin and Brown, 2003). …”

Section: Discussionmentioning

confidence: 99%

Differential effects of dopamine and opioid receptor blockade on motivated Coca-Cola drinking behavior and associated changes in brain, skin and muscle temperatures

Kiyatkin

2010

Neuroscience

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Although pharmacological blockade of both dopamine (DA) and opiate receptors has an inhibiting effect on appetitive motivated behaviors, it is still unclear which physiological mechanisms affected by these treatments underlie the behavioral deficit. To clarify this issue, we examined how pharmacological blockade of either DA (SCH23390 + eticlopride at 0.2 mg/kg each) or opioid receptors (naloxone 1 mg/kg) affects motor activity and temperature fluctuations in the nucleus acumens (NAcc), temporal muscle, and facial skin associated with motivated Coca-Cola drinking behavior in rats. In drug-free conditions, presentation of a cup containing 5 ml of Coca-Cola induced locomotor activation and rapid NAcc temperature increases, which both transiently decreased during drinking, and phasically increased again after the cup was emptied. Muscle temperatures followed this pattern, but increases were weaker and more delayed than those in the NAcc. Skin temperature rapidly dropped after cup presentation, remained at low levels during consumption, and slowly restored during post-consumption behavioral activation.By itself, DA receptor blockade induced robust decrease in spontaneous locomotion, moderate increases in brain and muscle temperatures, and a relative increase in skin temperatures, suggesting metabolic activation coupled with adynamia. Following this treatment (∼180 min), motor activation to cup presentation and Coca-Cola consumption were absent, but rats showed NAcc and muscle temperature increases following cup presentation comparable to control. Therefore, DA receptor blockade does not affect significantly central and peripheral autonomic responses to appetitive stimuli, but eliminates their behavior-activating effects, thus disrupting appetitive behavior and blocking consumption. Naloxone alone slightly decreased brain and muscle temperatures and increased skin temperatures, pointing at the enhanced heat loss and possible minor inhibition of basal metabolic activity. This treatment (∼60 min) had minimal effects on the latencies of drinking, but increased its total duration, with licking interrupted by pauses and retreats. This behavioral attenuation was coupled with weaker than in control locomotor activation and diminished temperature fluctuations in each recording location. Therefore, attenuation of normal behavioral and physiological responses to appetitive stimuli appears to underlie modest inhibiting effects of opiate receptor blockade on motivated behavior and consumption. * Corresponding author; tel.: (443)-740-2844 tel.: (443)-740- , Fax: (443)-740-2155, ekiyatki@intra.nida.nih.gov. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect ...

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Involvement of endorphins in emotional hyperthermia of rats

Cited by 134 publications

References 21 publications

Stress-induced hyperthermia in the rat: comparison of classical and novel recording methods

Stress-induced hyperthermia in the rat: comparison of classical and novel recording methods

Adrenal and Thyroid Interactions of -Endorphin-Induced Body Temperature Responses of Rats at 24.5 C

Differential effects of dopamine and opioid receptor blockade on motivated Coca-Cola drinking behavior and associated changes in brain, skin and muscle temperatures

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