Involvement of essential trace elements in the pathogenesis of hepatitis C virus‑related chronic liver disease and nonalcoholic steatohepatitis

Himoto, Takashi; Fujita, Koji; Mimura, Shima; Tani, Joji; Morishita, Asashiro; Kubota, Satoru; Masaki, Tsutomu

doi:10.3892/etm.2023.12307

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…These tests include measurements of alanine aminotransferase (ALT), aspartate aminotransferase (AST), the ALT/AST ratio, gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP). The liver is not only sensitive to a variety of factors but is also intimately involved in the metabolism of numerous trace elements in the body ( 3 , 4 ). In the multifaceted study of liver health, the role of trace minerals has received increasing attention ( 5–8 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of dietary selenium and blood concentration on liver function: a population-based study

Liang,

Huang,

Peng

et al. 2024

Front. Nutr.

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BackgroundEvidence on the association between selenium and liver function parameters is limited and controversial.MethodsData on dietary selenium intake, blood selenium concentration, and liver function parameters were obtained from the National Health and Nutrition Examination Survey (NHANES) 2017–2020. Associations between selenium (dietary intake and blood concentration) and liver function parameters [alanine aminotransferase (ALT), aspartate aminotransferase (AST), the ALT/AST ratio, gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP)] were assessed using multivariate linear regression models. Subgroup analyses and interaction tests were conducted to examine differences in associations according to age, gender, body mass index (BMI), diabetes, and physical activity.ResultsThe study included 6,869 participants after screening. The multivariate linear regression model revealed that dietary selenium intake was positively associated with ALT (β = 0.112, 95% CI = 0.041, 0.183) and the ALT/AST ratio (β = 0.002, 95% CI = 0.001, 0.004) after adjustment for covariates. Results of blood selenium concentration also showed that higher blood selenium levels were positively associated with ALT (β = 0.436, 95% CI = 0.308, 0.564), AST (β = 0.112, 95% CI = 0.015, 0.208), and the ALT/AST ratio (β = 0.012, 95% CI = 0.009, 0.015). However, ALP decreased with increasing blood selenium concentration (β = −0.207, 95% CI = −0.414, −0.000). In addition, we found significant differences in the effect of selenium on liver function parameters according to age, gender, and BMI.ConclusionDietary selenium intake and blood concentration affect liver function parameters. These findings suggest that further research is needed to explore these associations to promote liver health and disease prevention.

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Section: Introductionmentioning

confidence: 99%

Impact of dietary selenium and blood concentration on liver function: a population-based study

Liang,

Huang,

Peng

et al. 2024

Front. Nutr.

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Key challenges of post-liver transplant weight management

Cigrovski Berkovic,

Šeša,

Balen

et al. 2024

World J Transplant

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Liver transplantation serves as a life-saving intervention for patients with end-stage liver disease, yet long-term survival remains a challenge. Post-liver transplant obesity seems to have a significant contribution to this challenge and it emerges as a significant risk factor for graft steatosis, metabolic syndrome and de-novo malignancy development. This review synthesizes current literature on prevalence, risk factors and management strategies for post-liver transplant obesity, emphasizing its impact on graft and patient survival. Literature review consultation was conducted in Medline/PubMed, SciELO and EMBASE, with the combination of the following keywords: Weight management, liver transplantation, immunosuppressive therapy, lifestyle interventions, bariatric surgery. Immunosuppressive therapy has a significant influence on long-term survival of liver transplant patients, yet it seems to have lesser effect on post-transplant obesity development than previously thought. However, it significantly contributes to the development of other components of metabolic syndrome. Key predisposing factors for post-transplant obesity development encompass elevated recipient and donor body mass index, a history of alcoholic liver disease, hepatocellular carcinoma, male gender, the absence of cellular rejection and the marital status of the recipient. Tailored immunosuppressive regimens, pharmacotherapy, lifestyle interventions and bariatric surgery represent key components in mitigating post-transplant obesity and improving long-term survival and quality of life in this group of patients. Timely identification and intervention thus hold paramount importance. Further research is warranted to refine optimal management strategies and enhance outcomes in this patient population.

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Involvement of essential trace elements in the pathogenesis of hepatitis C virus‑related chronic liver disease and nonalcoholic steatohepatitis

Cited by 2 publications

References 48 publications

Impact of dietary selenium and blood concentration on liver function: a population-based study

Impact of dietary selenium and blood concentration on liver function: a population-based study

Key challenges of post-liver transplant weight management

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