Involvement of Extracellular Signal‐Regulated Kinase in Leukocyte Adsorption‐Induced Production of Hepatocyte Growth Factor

Nishise, Shoichi; Sasaki, Yu; Ueno, Yoshiyuki

doi:10.1111/1744-9987.12116

Cited by 3 publications

(7 citation statements)

References 4 publications

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“…We have already reported that cytokine release (e.g. IL‐1ra, HGF, IL‐10, and TNF‐α) is augmented by GM adsorption to CA beads . Thus, we expected that TGF‐β release would be augmented by incubation with CA beads because platelets, which produce TGF‐β, are also adsorbed (Fig.…”

Section: Resultsmentioning

confidence: 89%

“…These devices comprise a column filled with 2‐mm cellulose acetate (CA) beads that act as carriers for adsorptive leukocyte apheresis. We previously reported that contact between peripheral blood and CA beads induces the release of not only anti‐inflammatory cytokines, including IL‐1 receptor antagonist (IL‐1ra), hepatocyte growth factor (HGF), and IL‐10 , but also pro‐inflammatory cytokines, such as tumor necrosis factor‐α (TNF‐α) . These cytokines are released via the stimulation of GM adsorption to CA beads.…”

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confidence: 99%

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Effect of Cellulose Acetate Beads on the Release of Transforming Growth Factor‐β

et al. 2015

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Transforming growth factor-β (TGF-β) is released by activated platelets and induces the differentiation of T-helper 17 from naïve T cells. Contact between blood and cellulose acetate (CA) beads induces cytokine release, although their inflammatory effects on TGF-β release are unclear. We aimed to clarify the effect of CA beads on the release of TGF-β in vitro. We incubated peripheral blood with and without CA beads and measured platelets and TGF-β. Compared with blood samples incubated without beads, the platelet count and amount of TGF-β significantly decreased in blood samples incubated with CA beads. In conclusion, CA beads inhibited the release of TGF-β from adsorbed platelets. The biological effects of this reduction of TGF-β release during platelet adsorption to CA beads need further clarification.

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Section: Resultsmentioning

confidence: 89%

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confidence: 99%

Effect of Cellulose Acetate Beads on the Release of Transforming Growth Factor‐β

et al. 2015

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“…The release of anti‐inflammatory cytokines such as IL‐1ra and HGF is positively correlated with the ratio of adsorbed granulocytes to CA beads . Therefore, increased GM adsorption to CA beads is expected to provide improved anti‐inflammatory effects during GMA therapy by increasing the release of anti‐inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…Although the precise mechanisms of the clinical benefits of Adacolumn are unclear, GM adsorption likely triggers various biological responses such as the release of anti‐inflammatory substances and may contribute to the restoration of normal immune function. We previously reported that contact between peripheral blood and CA beads increases plasma anti‐inflammatory cytokine concentrations, including interleukin‐1 receptor antagonist (IL‐1ra) and hepatocyte growth factor (HGF) and that increased ratios of both IL‐1ra and HGF were positively correlated with the ratios of adsorbed granulocytes to CA beads . Thus, our previous reports suggest that an increase in adsorbed GMs to CA beads may provide more powerful anti‐inflammatory effects of GMA by increasing the release of anti‐inflammatory cytokines.…”

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confidence: 95%

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Effect of Temperature on Granulocyte and Monocyte Adsorption to Cellulose Acetate Beads

et al. 2017

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Granulocyte and monocyte (GM) adsorptive apheresis (GMA) is an effective therapy for inflammatory disorders including inflammatory bowel disease (IBD). During GMA, the blood of a patient with IBD passes through a column to contact cellulose acetate (CA) beads at a temperature below body temperature, likely close to room temperature. Here we investigated the effect of temperature on GM adsorption to CA beads in vitro. We incubated peripheral blood with and without CA beads at 5°C, 25°C, 37°C, and 43°C and calculated the ratios of adsorbed GMs. The ratios of adsorbed GMs increased as the temperature was raised. Additionally, we measured complement activation fragment concentrations. C3a and C5a concentrations also increased as the temperature was raised, and C5a concentrations had a positive correlation with the ratios of adsorbed GMs. These results suggest that warming the column during GMA might increase GM adsorption to CA beads, thereby enhancing the clinical efficacy of GMA.

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Relationship Between Tumor Necrosis Factor‐α Release and Granulocyte and Monocyte Adsorption to Cellulose Acetate Beads

et al. 2014

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Tumor necrosis factor-α, (TNF)-α, a proinflammatory cytokine, is produced by activated granulocytes and monocytes (GMs) and implicated as a major factor in inflammatory bowel disease (IBD) pathogenesis. Reduction of TNF-α should improve IBD pathology. GM adsorptive apheresis (GMA) is an effective therapy for inflammatory disorders including IBD. GM adsorption to cellulose acetate (CA) beads induces anti-inflammatory cytokine release, although these effects on TNF-α release are not clarified. We hypothesized that GMA may inhibit TNF-α release. The aim of the present study was to clarify the effects of GM adsorption to CA beads on TNF-α release in vitro. Peripheral blood was incubated with and without CA beads and TNF-α was measured. For comparison, TNF-α was measured in another lipopolysaccharide (LPS)-containing peripheral blood sample incubated similarly. The amount of TNF-α in blood samples incubated with CA beads was significantly higher than in those incubated without beads, although it was significantly lower than TNF-α incubated with LPS-containing sample without beads. The amount of TNF-α after incubation with CA beads positively correlated with GM adsorption ratio. GM adsorption to CA beads induced a small amount of TNF-α release. This is the first report on TNF-α release induced via GM adsorption stimuli. The biological effects of TNF-α release during GM adsorption need to be clarified.

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Involvement of Extracellular Signal‐Regulated Kinase in Leukocyte Adsorption‐Induced Production of Hepatocyte Growth Factor

Cited by 3 publications

References 4 publications

Effect of Cellulose Acetate Beads on the Release of Transforming Growth Factor‐β

Effect of Cellulose Acetate Beads on the Release of Transforming Growth Factor‐β

Effect of Temperature on Granulocyte and Monocyte Adsorption to Cellulose Acetate Beads

Relationship Between Tumor Necrosis Factor‐α Release and Granulocyte and Monocyte Adsorption to Cellulose Acetate Beads

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