Involvement of Fcα/μR (CD351) in autoantibody production

Yoshizawa, Yuichi; Honda, Shin‐ichiro; Shibuya, Akira

doi:10.1016/j.molimm.2013.10.002

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…Amphibian FcamrR binds IgM and IgX, does not require the J chain, and is expressed by amphibian splenic APCs (called XL cells) but not by mucosal epithelia [26,63]. FcamrR is the only identified IgM or IgA receptor on mammalian FDC, and modulates antibody responses by mechanisms that are not fully understood [64,65]. Although the exact function of FcamrR on FDC remains unclear, it may restrict the availability of antigen to B cells to facilitate affinity maturation, while still contributing to IC retention.…”

Section: Discussionmentioning

confidence: 99%

Identification of the Fc‐alpha/mu receptor in Xenopus provides insight into the emergence of the poly‐Ig receptor (pIgR) and mucosal Ig transport

et al. 2021

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The polyimmunoglobulin receptor (pIgR) transcytoses J chain-containing antibodies through mucosal epithelia. In mammals, two cis-duplicates of PIGR, FCMR, and FCAMR, flank the PIGR gene. A PIGR duplication is first found in amphibians, previously annotated as PIGR2 (herein xlFCAMR), and is expressed by APCs. We demonstrate that xlFcamR is the equivalent of mammalian FcamR. It has been assumed that pIgR is the oldest member of this family, yet our data could not distinguish whether PIGR or FCAMR emerged first; however, FCMR was the last family member to emerge. Interestingly, bony fish "pIgR" is not an orthologue of tetrapod pIgR, and possibly acquired its function via convergent evolution. PIGR/FCAMR/FCMR are members of a larger superfamily, including TREM, CD300, and NKp44, which we name the "double-disulfide Ig superfamily" (ddIgSF). Domains related to each ddIgSF family were identified in cartilaginous fish (sharks, chimeras) and encoded in a single gene cluster syntenic to the human pIgR locus. Thus, the ddIgSF families date back to the earliest antibody-based adaptive immunity, but apparently not before. Finally, our data strongly suggest that the J chain arose in evolution only for Ig multimerization. This study provides a framework for further studies of pIgR and the ddIgSF in vertebrates.

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Section: Discussionmentioning

confidence: 99%

Identification of the Fc‐alpha/mu receptor in Xenopus provides insight into the emergence of the poly‐Ig receptor (pIgR) and mucosal Ig transport

et al. 2021

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“…IgM is likewise recognized by FcμR, expressed on B cells in mice and B, T, and NK lymphocytes in humans, which mediates developing B cell activation and subtype distribution [121,122], and is responsible for regulating IgM titers [123]. Interestingly, soluble IgM has been reported to be involved in the suppression of autoantibody production [124], with FcμR possibly mediating this function [125], thus making this IgM-FcμR interaction a potential interest for atherosclerosis research.…”

Section: Antibodies In Action: Igmmentioning

confidence: 99%

Antibodies in action: the role of humoral immunity in the fight against atherosclerosis

et al. 2022

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The sequestering of oxidation-modified low-density lipoprotein by macrophages results in the accumulation of fatty deposits within the walls of arteries. Necrosis of these cells causes a release of intercellular epitopes and the activation of the adaptive immune system, which we predict leads to robust autoantibody production. T cells produce cytokines that act in the plaque environment and further stimulate B cell antibody production. B cells in atherosclerosis meanwhile have a mixed role based on subclass. The current model is that B-1 cells produce protective IgM antibodies in response to oxidation-specific epitopes that work to control plaque formation, while follicular B-2 cells produce class-switched antibodies (IgG, IgA, and IgE) which exacerbate the disease. Over the course of this review, we discuss further the validation of these protective antibodies while evaluating the current dogma regarding class-switched antibodies in atherosclerosis. There are several contradictory findings regarding the involvement of class-switched antibodies in the disease. We hypothesize that this is due to antigen-specificity, and not simply isotype, being important, and that a closer evaluation of these antibodies’ targets should be conducted. We propose that specific antibodies may have therapeutical potential in preventing and controlling plaque development within a clinical setting.

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Transcriptomic Analysis of LNCaP Tumor Xenograft to Elucidate the Components and Mechanisms Contributed by Tumor Environment as Targets for Dietary Prostate Cancer Prevention Studies

Huang

et al. 2021

Nutrients

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LNCaP athymic xenograft model has been widely used to allow researchers to examine the effects and mechanisms of experimental treatments such as diet and diet-derived cancer preventive and therapeutic compounds on prostate cancer. However, the biological characteristics of human LNCaP cells before/after implanting in athymic mouse and its relevance to clinical human prostate outcomes remain unclear and may dictate interpretation of biological efficacies/mechanisms of diet/diet-derived experimental treatments. In this study, transcriptome profiles and pathways of human prostate LNCaP cells before (in vitro) and after (in vivo) implanting into xenograft mouse were compared using RNA-sequencing technology (RNA-seq) followed by bioinformatic analysis. A shift from androgen-responsive to androgen nonresponsive status was observed when comparing LNCaP xenograft tumor to culture cells. Androgen receptor and aryl-hydrocarbon pathway were found to be inhibited and interleukin-1 (IL-1) mediated pathways contributed to these changes. Coupled with in vitro experiments modeling for androgen exposure, cell-matrix interaction, inflammation, and hypoxia, we identified specific mechanisms that may contribute to the observed changes in genes and pathways. Our results provide critical baseline transcriptomic information for a tumor xenograft model and the tumor environments that might be associated with regulating the progression of the xenograft tumor, which may influence interpretation of diet/diet-derived experimental treatments.

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Involvement of Fcα/μR (CD351) in autoantibody production

Cited by 4 publications

References 31 publications

Identification of the Fc‐alpha/mu receptor in Xenopus provides insight into the emergence of the poly‐Ig receptor (pIgR) and mucosal Ig transport

Identification of the Fc‐alpha/mu receptor in Xenopus provides insight into the emergence of the poly‐Ig receptor (pIgR) and mucosal Ig transport

Antibodies in action: the role of humoral immunity in the fight against atherosclerosis

Transcriptomic Analysis of LNCaP Tumor Xenograft to Elucidate the Components and Mechanisms Contributed by Tumor Environment as Targets for Dietary Prostate Cancer Prevention Studies

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