Involvement of GDNF and its receptors in the maturation of the periodontal Ruffini endings

Igarashi, Yasushi; Aita, Megumi; Suzuki, Akiko; Nandasena, Tharanga; Kawano, Yoshiro; Nozawa-Inoue, Kayoko; Maeda, Takeyasu

doi:10.1016/j.neulet.2006.11.012

Cited by 7 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At this stage, a drastic increase in type B cells serving to produce synovial fluids, which make smooth jaw movement possible, has been reported in the rat TMJ (Tsuyama et al, 1995;Ikeda et al, 2004). Our investigations revealed that the mechanoreceptors increased drastically in number and showed their maturation at P15 to P24 in the periodontal ligament, which serves as a sensory apparatus of the masticatory system (Nakakura-Ohshima et al, 1993Igarashi et al, 2007), suggesting the involvement of added functional stimuli such as occlusal force in the development and maturation of the masticatory apparatus. Taking these findings together, it is conceivable that the expression of Cav3 in the type B cells is closely related to jaw movement because TMJ might be influenced by mechanical stress due to occlusal loading.…”

Section: )supporting

confidence: 55%

Immunocytochemical Localization of Caveolin‐3 in the Synoviocytes of the Rat Temporomandibular Joint During Development

Niwano¹,

Nozawa-Inoue²,

Suzuki³

et al. 2008

The Anatomical Record

Self Cite

View full text Add to dashboard Cite

Caveolins-caveolin-1, -2, -3 (Cav1, 2, 3)-are major components of caveolae, which have diverse functions. Our recent study on the temporomandibular joint (TMJ) revealed expressions of Cav1 and muscle-specific Cav3 in some synovial fibroblast-like type B cells with well-developed caveolae. However, the involvement of Cav3 expression in the differentiation and maturation of type B cells remains unclear. The present study therefore examined the chronological alterations in the localization of Cav3 in the synovial lining cells of the rat TMJ during postnatal development by immunocytochemical techniques. Observations showed immature type B cells possessed a few caveolae with Cav1 but lacked Cav3 protein at postnatal day 5 (P5). At P14, Cav3-immunopositive type B cells first appeared in the synovial lining layer. They increased in number and immunointensity from P14 to P21 as occlusion became active. In immunoelectron microscopy and double immunolabeling with heat shock protein 25 (Hsp25) and Cav3, coexpressed type B cells developed rough endoplasmic reticulum and numerous caveolae, while the Cav3-immunonegative type B cell with Hsp25 immunoreaction possessed few of these. Results suggest that Cav3 expression, which is closely related to added functional stimuli, reflects the differentiation of the type B synoviocytes. Anat Rec,

show abstract

Section: )supporting

confidence: 55%

Immunocytochemical Localization of Caveolin‐3 in the Synoviocytes of the Rat Temporomandibular Joint During Development

Niwano¹,

Nozawa-Inoue²,

Suzuki³

et al. 2008

The Anatomical Record

Self Cite

View full text Add to dashboard Cite

show abstract

“…In contrast, abundant Ret + neurons persisted in the Brn3a -/- TG (Figure 2P, R). Ret is expressed in non-peptidergic nociceptors, which initially co-express TrkA [38], and also in earlier-developing neurons with large cell bodies, which are likely to include certain classes of mechanoreceptors [40]. In the Brn3a -/- TG at P0 the persisting Ret + neurons appear to belong to the latter class, in that they have large cell bodies, and do not co-express Runx1 (Figure 2O, P), or TrkA (Figure 2Q, R).…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, early-differentiating Ret + neurons are undiminished in the Brn3a knockout (Figure 4M-P). These early Ret + neurons do not co-express TrkA or Runx1, either in control or Brn3a -/- TG, and probably constitute a subset of mechanoreceptors [40]. …”

Section: Resultsmentioning

confidence: 99%

Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation

et al. 2010

View full text Add to dashboard Cite

The transcription factor Brn3a, product of the pou4f1 gene, is expressed in most sensory neurons throughout embryogenesis. Prior work has demonstrated a role for Brn3a in the repression of early neurogenic genes; here we describe a second major role for Brn3a in the specification of sensory subtypes in the trigeminal ganglion (TG). Sensory neurons initially co-express multiple Trk-family neurotrophin receptors, but are later marked by the unique expression of TrkA, TrkB or TrkC. Maturation of these sensory subtypes is known to depend on the expression of Runx transcription factors. Newborn Brn3a knockout mice fail to express TrkC, which is associated in the TG with mechanoreceptors, plus a set of functional genes associated with nociceptor subtypes. In embryonic Brn3a-/- ganglia, the normal expression of Runx3 is never initiated in TrkC+ neurons, and Runx1 expression is greatly attenuated in TrkA+ nociceptors. These changes are accompanied by expanded expression of TrkB in neurons that abnormally express multiple Trks, followed by the loss of TrkC and TrkA expression. In transgenic embryos expressing a Brn3a-VP16 dominant transactivator, Runx3 mRNA expression is increased, suggesting that it is a direct regulatory target of Brn3a. Chromatin immunoprecipitation confirms that Brn3a binds in vivo to a conserved upstream enhancer element within histone H3-acetylated chromatin in the Runx3 locus. Together these data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes.

show abstract

“…This neurotrophic factor is believed to be involved in tooth morphogenesis 40 . GDNF and its receptors were reported to be related to the maturation of the periodontal Ruffini endings, 41 and those neural endings might be closely connected to the ERM 42 . It can be speculated that GDNF produced by ERM may maintain the nerve endings in the periodontal ligament.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Characterization of the Cytokine Profile of the Epithelial Cell Rests of Malassez

Ohshima

Yamaguchi

Micke

et al. 2008

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

Involvement of GDNF and its receptors in the maturation of the periodontal Ruffini endings

Cited by 7 publications

References 25 publications

Immunocytochemical Localization of Caveolin‐3 in the Synoviocytes of the Rat Temporomandibular Joint During Development

Immunocytochemical Localization of Caveolin‐3 in the Synoviocytes of the Rat Temporomandibular Joint During Development

Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation

In Vitro Characterization of the Cytokine Profile of the Epithelial Cell Rests of Malassez

Contact Info

Product

Resources

About