Involvement of Glycogen Synthase Kinase-3β and Oxidation Status in the Loss of Cardioprotection by Postconditioning in Chronic Diabetic Male Rats

Badalzadeh, Reza; Mohammadi, Mustafa; Yousefi, Bahman; Farajnia, S; Najafi, Moslem; Mohammadi, Shima

doi:10.15171/apb.2015.045

Cited by 29 publications

(19 citation statements)

References 31 publications

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“…Therefore, regenerative medicine has become the center of attention in recent decades and opens new avenues in the offering therapies for patients with end‐stage organ failure. Since Wnt/β‐catenin signaling pathway has essential roles in the regulation of the progenitor cell fate, developmental decisions, proliferation during embryonic development, and adult tissue homeostasis, it has been the subject of a huge number of researches for investigating its possible role in progenitor cell function during regeneration (Badalzadeh et al, ; Jahanban‐Esfahlan, Mehrzadi et al, ). Multiple studies have reported the expression of Wnt ligands and components of the β‐catenin signaling pathway in regenerating amphibian and fish appendages, and other studies have documented that Wnt/β‐catenin signaling is functionally contributed in the proliferation of cells during regeneration of mammalian muscle, liver, and bone (Stoick‐Cooper, Weidinger et al, ).…”

Section: Introductionmentioning

confidence: 99%

The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

Majidinia

Akhondian²,

Jahanban‐Esfahlani³

et al. 2018

Journal Cellular Physiology

Self Cite

107

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Regenerative medicine is a translational field which combines tissue engineering and molecular biology to construct spare organs or help injured or defective tissues to regenerate or restore their normal functions. This is particularly important with specific organs such as heart, central nervous system, retina, or limbs which possess very limited regenerative capacity. As such, regenerative medicine has received peculiar attention in the last decade. In this regard, Wnt/β-catenin signaling pathway has been subject to intensive research, since it plays many essential roles in the regulation of the progenitor cell fate, developmental decisions, proliferation during embryonic development, and adult tissue homeostasis. In this paper, we will briefly introduce Wnt/β-catenin signaling pathway and discuss how it integrally contributes to both stem and cancer stem cell maintenance. Finally, we summarize the current understanding of the role of Wnt/β-catenin signaling in the development and regeneration of heart, lung, liver, bone, and cartilage.

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Section: Introductionmentioning

confidence: 99%

The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

Majidinia

Akhondian²,

Jahanban‐Esfahlani³

et al. 2018

Journal Cellular Physiology

Self Cite

107

View full text Add to dashboard Cite

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“…In order to allow its function, the maintenance of sufficient blood, oxygen and nutrients is required (10). Energy is supplied to myocardial cells primarily through β-oxidation of fatty acids under aerobic conditions (11) and myocardial cells almost completely depend on aerobic metabolism to supply energy. Therefore, myocardial cells have a high dependency on oxygen.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, myocardial cells have a high dependency on oxygen. Myocardial cells have a high sensitivity to ischemia and anoxia; once myocardial cells suffer ischemia and anoxia, cell dysfunction, paramorphia and potentially death may occur (11).…”

Section: Introductionmentioning

confidence: 99%

Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways

Yang

Zhao

et al. 2018

Mol Med Report

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Cardiovascular diseases are common diseases in Sweden as in most countries. In 2016, 25,700 persons suffered from coronary heart disease (CHD) and 25% of these died within 28 days. The present study investigated whether dioscin may exert protective effects against CHD‑induced heart apoptosis, oxidative stress and inflammation in a pig model and the potential underlying mechanisms. Adult pigs were used to establish a CHD model group and 80 mg/kg dioscin was administered for 4 weeks. Histological analysis and measurement of serum levels of heart injury markers demonstrated that 80 mg/kg dioscin markedly alleviated CHD, while left ventricular ejection fraction and left ventricular systolic internal diameter measurements indicated that 80 mg/kg dioscin also increased heart function in the CHD pig model. Furthermore, western blotting demonstrated that 80 mg/kg dioscin significantly reduced protein levels of apoptosis markers in the heart of CHD model pigs, including Bcl‑2‑associated X and caspase‑3, potentially via the suppression of poly (ADP‑ribose) polymerase 1 (PARP)/p53 expression. Additionally, the results of ELISA and western blotting demonstrated that 80 mg/kg dioscin may reduce oxidative stress and inflammation in CHD model pigs through the promotion of sirtuin 1 (Sirt1)/nuclear factor erythroid 2‑related factor 2 (Nrf2) protein expression and the suppression of PARP/p53 and p38 mitogen‑activated protein kinase (MAPK) expression. The results of the current study indicate that dioscin may protect against CHD by regulating oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways.

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“…As such, the authors concluded that NER deficiency might have a key role in the etiology of sporadic breast cancer. Additionally, it was also suggested that polymorphisms in particular genes in the NER pathway, such as XPD, ERCC2, and ERCC5, may increase the risk of breast cancer in subjects [57,58,[72][73][74][75][76][77][78].…”

Section: Nucleotide Excision Repair (Ner) Pathwaymentioning

confidence: 99%

DNA repair and damage pathways in breast cancer development and therapy

Majidinia

Yousefi

2017

DNA Repair

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Involvement of Glycogen Synthase Kinase-3β and Oxidation Status in the Loss of Cardioprotection by Postconditioning in Chronic Diabetic Male Rats

Abstract: The failure of cardioprotection by IPostC in diabetic hearts may be attributed to the loss of phosphorylation of GSK-3β and thereby increase in oxidative stress in diabetic states.

Cited by 29 publications

References 31 publications

The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways

DNA repair and damage pathways in breast cancer development and therapy

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