Involvement of gold and silver nanoparticles in lung cancer nanomedicines: A review

Sehgal, Shelly; Kumar, Jitendra; Nishtha,

doi:10.1016/j.matpr.2022.04.199

Cited by 11 publications

(4 citation statements)

References 65 publications

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“…Among these, non-small-cell lung cancer accounts for 85% of all lung cancers. Because of this rate, NSCLC is the main source of tumor-related deaths globally, emphasizing the need for ever more effective treatment methods [ 5 ]. There are many scientific studies on nanodrug systems using nanotechnology in lung cancer treatment methods.…”

Section: Resultsmentioning

confidence: 99%

“…AgNPs could be used as carriers or antimicrobial agents, as indicated by silver nanoparticles incorporated into membrane systems or microbicidal layers with antibacterial activity [ 5 ]. It has been shown in various studies that drug-loaded silver nanoparticles have antimicrobial activities.…”

Section: Resultsmentioning

confidence: 99%

“…Cancer is the global cause of death in both high-income and middle-income countries [ 5 ]. According to the Global Cancer Observatory (GLOBOCAN), the five cancers with the highest death rates worldwide are lung cancer (18%), colorectal cancer (9.4%), liver cancer (8.3%), stomach cancer (7.7%), and breast cancer (6.9%) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Paclitaxel-Loaded Silver Nanoparticles: Evaluation of Cytotoxic Effects and Antimicrobial Activity

Tunç,

Hepokur,

Kari̇per

2024

Bioinorganic Chemistry and Applications

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Carrier system therapies based on combining cancer drugs with nanoparticles have been reported to control tumor growth and significantly reduce the side effects of cancer drugs. We thought that paclitaxel-loaded silver nanoparticles (AgNPs-PTX) were the right carrier to target cancer cells. We also carried out antimicrobial activity experiments as systems formed with nanoparticles have been shown to have antimicrobial activity. In our study, we used easy-to-synthesize and low-cost silver nanoparticles (AgNPs) with biocatalytic and photocatalytic advantages as drug carriers. We investigated the antiproliferative activities of silver nanoparticles synthesized by adding paclitaxel on MCF-7 (breast adenocarcinoma cell line), A549 (lung carcinoma cell line), C6 (brain glioma cell line) cells, and healthy WI-38 (fibroblast normal cell line) cell lines and their antimicrobial activities on 10 different microorganisms. The synthesized AgNPs and AgNPs-PTX were characterized by dynamic light scattering (DLS), scanning transmission electron microscopy, UV-visible spectroscopy, Fourier transform infrared spectroscopy, and X-ray spectroscopy. The nanoparticles were spherical in shape, with AgNPs ranging in size from 2.32 to 5.6 nm and AgNPs-PTXs from 24.36 to 58.77 nm. AgNPs demonstrated well stability of −47.3 mV, and AgNPs-PTX showed good stability of −25.4 mV. The antiproliferative effects of the synthesized nanoparticles were determined by XTT (tetrazolium dye; 2,3-bis-(2-methoxy-4-nitro-5-sulfenyl)-(2H)-tetrazolium-5-carboxanilide), and the proapoptotic effects were determined by annexin V/propidium iodide (PI) staining. The effect of AgNPs-PTX was more effective, and anticancer activity was higher than PTX in all cell lines. When selectivity indices were calculated, AgNPs-PTX was more selective in the A549 cell line (SI value 6.53 μg/mL). AgNPs-PTX was determined to increase apoptosis cells by inducing DNA fragmentation. To determine the antimicrobial activity, the MIC (minimum inhibitory concentration) test was performed using 8 different bacteria and 2 different fungi. Seven of the 10 microorganisms tested exhibited high antimicrobial activity according to the MIC ≤100 μg/mL standard, reaching MIC values below 100 μg/mL and 100 μg/mL for both AgNPs and AgNPs-PTX compared to reference sources. Compared to standard antibiotics, AgNPs-PTX was highly effective against 4 microorganisms.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Synthesis and Characterization of Paclitaxel-Loaded Silver Nanoparticles: Evaluation of Cytotoxic Effects and Antimicrobial Activity

Tunç,

Hepokur,

Kari̇per

2024

Bioinorganic Chemistry and Applications

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“…One characteristic of Ag-NPs is consistent with cancer cells, that is, with the rapid proliferation of cancer cells, cancer cells will accelerate their division and exhibit a greater metabolic rate, which leads to a more rapid internalization of Ag-NPs, leading to cell death. Studies have shown that silver nanoparticles can prevent and attenuate cancer by comparing vehicle-treated tumors with silver nanoparticles-treated tumors and have a good selectivity for non-small cell lung cancer, which is a good tool for early prevention and diagnosis of lung cancer [5].…”

Section: Metal Npsmentioning

confidence: 99%

Application of Inorganic Nanomaterials for Drug Delivery in Lung Cancer

2023

ACE

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Lung cancer has been one of the most common cancers in the world for more than 100 years and has taken many people's lives. Many people suffer from lung cancer due to smoking, second-hand smoke, and serious air pollution or pollutant gathering environment. It is necessary to find a good medical solution. Compared with traditional chemotherapy and immunotherapy, targeted therapy has more advantages in the impact on patients and the efficiency of treatment. How to develop targeted therapeutic drugs has become a topic, and nanoscale targeted drugs have become the most appropriate choice. Among them, there are many inorganics suitable for nano-targeted drugs and nano-drug carriers, such as metals, metal oxides, and non-metals. By blocking the genetic material in lung cancer cells, it can avoid the division and differentiation of lung cancer cells, so as to achieve the purpose of treating lung cancer. This review will focus on the above three kinds of nano-targeted drugs, and discuss their therapeutic principles, drug delivery, activation mode, and biotoxicity.

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Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

Kumar

Shukla

Sharma

et al. 2023

MedComm

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Cancer is a disease associated with complex pathology and one of the most prevalent and leading reasons for mortality in the world. Current chemotherapy has challenges with cytotoxicity, selectivity, multidrug resistance, and the formation of stemlike cells. Nanomaterials (NMs) have unique properties that make them useful for various diagnostic and therapeutic purposes in cancer research. NMs can be engineered to target cancer cells for early detection and can deliver drugs directly to cancer cells, reducing side effects and improving treatment efficacy. Several of NMs can also be used for photothermal therapy to destroy cancer cells or enhance immune response to cancer by delivering immune‐stimulating molecules to immune cells or modulating the tumor microenvironment. NMs are being modified to overcome issues, such as toxicity, lack of selectivity, increase drug capacity, and bioavailability, for a wide spectrum of cancer therapies. To improve targeted drug delivery using nano‐carriers, noteworthy research is required. Several metal‐based NMs have been studied with the expectation of finding a cure for cancer treatment. In this review, the current development and the potential of plant and metal‐based NMs with their effects on size and shape have been discussed along with their more effective usage in cancer diagnosis and treatment.

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Involvement of gold and silver nanoparticles in lung cancer nanomedicines: A review

Cited by 11 publications

References 65 publications

Synthesis and Characterization of Paclitaxel-Loaded Silver Nanoparticles: Evaluation of Cytotoxic Effects and Antimicrobial Activity

Synthesis and Characterization of Paclitaxel-Loaded Silver Nanoparticles: Evaluation of Cytotoxic Effects and Antimicrobial Activity

Application of Inorganic Nanomaterials for Drug Delivery in Lung Cancer

Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

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