Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperating<i>MLL/AF10(OM-LZ)</i>and oncogenic<i>KRAS</i>in a mouse bone marrow transplantation model

Fu, Jen-Fen; Yen, Tzung‐Hai; Chen, Yu; Huang, Ying‐Jung; Hsu, Cheng–Lung; Liang, Der‐Cherng; Shih, Lee‐Yung

doi:10.1002/ijc.28195

Cited by 27 publications

(33 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Knocking down Gpr125 in murine myeloid sarcoma lines that harbor KRAS G12C and MLL/AF10(OM-LZ) oncogenes leads to reduced myeloid sarcoma burden in mice, and a decrease in cell adhesion in culture, possibly contributing to their reduced tumorigenicity [106]. …”

Section: Biological Functions Of Adhesion Gpcrs In Cancermentioning

confidence: 99%

See 1 more Smart Citation

Adhesion GPCRs in Tumorigenesis

Aust

Zhu

et al. 2016

Handbook of Experimental Pharmacology

View full text Add to dashboard Cite

Alterations in the homeostasis of several adhesion GPCRs (aGPCRs) have been observed in cancer. The main cellular functions regulated by aGPCRs are cell adhesion, migration, polarity, and guidance, which are all highly relevant to tumor cell biology. Expression of aGPCRs can be induced, increased, decreased, or silenced in the tumor or in stromal cells of the tumor microenvironment, including fibroblasts and endothelial and/or immune cells. For example, ADGRE5 (CD97) and ADGRG1 (GPR56) show increased expression in many cancers, and initial functional studies suggest that both are relevant for tumor cell migration and invasion. aGPCRs can also impact the regulation of angiogenesis by releasing soluble fragments following the cleavage of their extracellular domain (ECD) at the conserved GPCR-proteolytic site (GPS) or other more distal cleavage sites as typical for the ADGRB (BAI) family. Interrogation of in silico cancer databases suggests alterations in other aGPCR members and provides the impetus for further exploration of their potential role in cancer. Integration of knowledge on the expression, regulation, and function of aGPCRs in tumorigenesis is currently spurring the first preclinical studies to examine the potential of aGPCR or the related pathways as therapeutic targets.

show abstract

Section: Biological Functions Of Adhesion Gpcrs In Cancermentioning

confidence: 99%

“…Thus, downregulation of GPR124 is discussed as a therapeutic approach to overcome NSCLC gefitinib resistance [127]. Knockdown of Gpr125 reduces tumor cell aggregation and diminishes myeloid sarcoma formation induced by transplantation of immortalized acute myeloid leukemia [106]. …”

Section: Families Of Adhesion Gpcr In Tumorigenesismentioning

confidence: 99%

Adhesion GPCRs in Tumorigenesis

Aust

Zhu

et al. 2016

Handbook of Experimental Pharmacology

View full text Add to dashboard Cite

show abstract

“…Two studies use the same MSCV based BM transduction with MLL-AF10 and both models develop myeloid lineage disease (74, 75). An additional model studied the cooperativity of MLL-AF10 with the activating mutation Kras G12C (76). …”

Section: B Cell All Modelsmentioning

confidence: 99%

Murine Models of Acute Leukemia: Important Tools in Current Pediatric Leukemia Research

2014

View full text Add to dashboard Cite

Leukemia remains the most common diagnosis in pediatric oncology and, despite dramatic progress in upfront therapy, is also the most common cause of cancer-related death in children. Much of the initial improvement in outcomes for acute lymphoblastic leukemia (ALL) was due to identification of cytotoxic agents that are active against leukemia followed by the recognition that combination of these cytotoxic agents and prolonged therapy are essential for cure. Recent data demonstrating lack of progress in patients for whom standard chemotherapy fails suggests that the ability to improve outcome for these children will not be dramatically impacted through more intensive or newer cytotoxic agents. Thus, much of the recent research focus has been in the area of improving our understanding of the genetics and the biology of leukemia. Although in vitro studies remain critical, given the complexity of a living system and the increasing recognition of the contribution of leukemia extrinsic factors such as the bone marrow microenvironment, in vivo models have provided important insights. The murine systems that are used can be broadly categorized into syngeneic models in which a murine leukemia can be studied in immunologically intact hosts and xenograft models where human leukemias are studied in highly immunocompromised murine hosts. Both of these systems have limitations such that neither can be used exclusively to study all aspects of leukemia biology and therapeutics for humans. This review will describe the various ALL model systems that have been developed as well as discuss the advantages and disadvantages inherent to these systems that make each particularly suitable for specific types of studies.

show abstract

“…In this disease, which co-presents with acute myeloid leukemia, myeloid cells accumulate in peripheral tissues as a solid mass, atypical of blood borne tumors. In their study, Fu et al (Fu et al, 2013) showed that Gpr125, which is not typically expressed in hematopoietic lineages (Haitina et al, 2008), was upregulated in MS cells and that RNAi against Gpr125 decreased the adherent abilities of MS cells ex vivo . The mechanism for this observation is still unclear.…”

Section: Adhesion Gpcrs In Cancermentioning

confidence: 99%

Adhesion G-Protein-Coupled Receptors: Elusive Hybrids Come of Age

Simundza

Cowin

2013

Cell Communication & Adhesion

View full text Add to dashboard Cite

Adhesion G-protein coupled receptors (GPCRs) are the most recently identified and least understood subfamily of GPCRs. Adhesion GPCRs are characterized by unusually long ectodomains with adhesion-related repeats that facilitate cell-cell and cell-cell matrix contact, as well as a proteolytic cleavage site-containing domain that is a structural hallmark of the family. Their unusual chimeric structure of adhesion-related ectodomain with a seven-pass transmembrane domain and cytoplasmic signaling makes these proteins highly versatile in mediating cellular signaling in response to extracellular adhesion or cell motility events. The ligand binding and cytoplasmic signaling modes for members of this family are beginning to be elucidated, and recent studies have demonstrated critical roles for Adhesion GPCRs in planar polarity and other important cell-cell and cell-matrix interactions during development and morphogenesis, as well as heritable diseases and cancer.

show abstract

Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperatingMLL/AF10(OM-LZ)and oncogenicKRASin a mouse bone marrow transplantation model

Cited by 27 publications

References 32 publications

Adhesion GPCRs in Tumorigenesis

Adhesion GPCRs in Tumorigenesis

Murine Models of Acute Leukemia: Important Tools in Current Pediatric Leukemia Research

Adhesion G-Protein-Coupled Receptors: Elusive Hybrids Come of Age

Contact Info

Product

Resources

About