Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris

Sun, Chaonan; Chen, Ling; Yang, Huan; Sun, Hongjiang; Xie, Zhen; Zhao, Bei; Jiang, Xin; Qin, Bi; Shen, Zhu

doi:10.3389/fnut.2021.761978

Cited by 17 publications

(12 citation statements)

References 54 publications

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“…In patients with psoriatic arthritis, there was a decrease in the abundance of certain bacteria such as Akkermansia, Ruminococcus, Pseudobotyrivibrio, Paraacteroides, Alistipes, and Coprococcus [14,16,32]. In patients with psoriasis vulgaris showed changes in the proportions of Firmicutes and Bacteroides, and a decrease in the abundance of Actinomyces, Vitallis, and Coprococcus [11,14,33]. However, the conclusions of various studies are not consistently the same.…”

Section: Discussionmentioning

confidence: 99%

Association between gut microbiota and psoriasis: a bidirectional two-sample Mendelian randomization study

Zhang,

Xiang,

Shen

et al. 2023

Preprint

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Background: Research has found that the composition of gut microbiota is related to psoriasis and its subtypes. However, the causal effect of gut microbiota on psoriasis is still unclear. Methods: A two sample Mendelian randomization randomized study was conducted using the aggregated statistical data of intestinal microbiota in the meta-analysis of the largest available genome-wide association studies conducted by the MiBioGen Alliance. The summary statistical data for psoriasis, arthropathic psoriasis, and psoriasis vulgaris are from the FinnGen Alliance R7 release. Reverse variance weighting, maximum likelihood, MR Egger, weighted median, weighted model, MR-PRESSO, and cML MA were used to examine the causal relationship between gut microbiota and psoriasis, arthropathic psoriasis, and psoriasis vulgaris. In the forward Mendelian randomization randomization analysis, reverse Gregor Mendel randomization analysis was performed on bacteria found to have causal relationships with psoriasis, arthropathic psoriasis and psoriasis vulgaris. Cochran's Q statistics are used to quantify the heterogeneity of Instrumental variables estimation. Results: A higher genetically predicted abundance Odoribacter was associated with a reduced risk of psoriasis. While a higher genetically predicted abundance of Ruminiclostridium5 was associated with an increased risk of psoriasis. The genetically predicted relative abundance of Verrucomicrobiae, Verrucomicrobiaceae, Akkermansia, Verrucomicrobiales were positively associated with arthropathic psoriasis. A higher genetically predicted abundance of Rikenellaceae served as protective factors for arthropathic psoriasis. Specifically, a higher genetically predicted Atinomycetaceae, Eubacterium fissicatena group, Lactococcus, and Actinomycetales were associated with a higher risk of psoriasis vulgaris. In contrast, higher genetically predicted Odoribacter was a lower risk of psoriasis vulgaris. No significant heterogeneity or level pleiotropy of Instrumental variables estimation was found. Conclusion: This MR study offer novel perspectives regarding the prevention, advancement, and therapy of psoriasis by concentrating on specific bacterial groups. Additional research is required to specify the exact mechanism relating the association between gut microbiota and psoriasis along with its classifications.

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Section: Discussionmentioning

confidence: 99%

Association between gut microbiota and psoriasis: a bidirectional two-sample Mendelian randomization study

Zhang,

Xiang,

Shen

et al. 2023

Preprint

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“…More and more evidence has shown that the pathogenesis of psoriasis is related to the disorder of gut microbiota. The number, abundance and proportion of gut microbiota in patients with psoriasis are significantly changed 40,41 . The disorder of gut microbiota may induce the activation of systemic inflammation by affecting the function of immune cells and the secretion of cytokines, and affect the development of psoriasis 42 .…”

Section: Discussionmentioning

confidence: 99%

“…The number, abundance and proportion of gut microbiota in patients with psoriasis are significantly changed. 40 , 41 The disorder of gut microbiota may induce the activation of systemic inflammation by affecting the function of immune cells and the secretion of cytokines, and affect the development of psoriasis. 42 In addition to immune‐inflammatory pathways, the involvement of gut microbiota disorders in the pathogenesis of psoriasis may be related to the following factors: (1) Intestinal barrier function.…”

Section: Discussionmentioning

confidence: 99%

A bibliometrics study on the status quo and hot topics of pathogenesis of psoriasis based on Web of Science

Yang,

Zheng,

et al. 2024

Skin Research and Technology

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BackgroundPsoriasis is an immune‐mediated chronic inflammatory skin disease. Great progress has been made in the pathogenesis of psoriasis in recent years, but there is no bibliometric study on the pathogenesis of psoriasis. The purpose of this study was to use bibliometrics method to analyze the research overview and hot spots of pathogenesis of psoriasis in recent 10 years, so as to further understand the development trend and frontier of this field.MethodsThe core literatures on the pathogenesis of psoriasis were searched in the Web of Science database, and analyzed by VOSviewer, CiteSpace, and Bibliometrix in terms of the annual publication volume, country, institution, author, journal, keywords, and so on.ResultsA total of 3570 literatures were included. China and the United States were the main research countries in this field, and Rockefeller University was the main research institution. Krueger JG, the author, had the highest number of publications and the greatest influence, and Boehncke (2015) was the most cited local literature. J INVEST DERMATOL takes the top spot in terms of the number of Dermatol articles and citation frequency. The main research hotspots in the pathogenesis of psoriasis are as follows: (1) The interaction between innate and adaptive immunity and the related inflammatory loop dominated by Th17 cells and IL‐23/IL‐17 axis are still the key mechanisms of psoriasis; (2) molecular genetic studies represented by Long Non‐Coding RNA (LncRNA); (3) integrated research of multi‐omics techniques represented by gut microbiota; and (4) Exploring the comorbidity mechanism of psoriasis represented by Metabolic Syndrome (MetS).ConclusionThis study is a summary of the current research status and hot trend of the pathogenesis of psoriasis, which will provide some reference for the scholars studying the pathogenesis of psoriasis.

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“… 34 , 35 Turicibacter as a potential pathobiont and its interaction with the host are poorly understood, and thus its basic pathogenic mechanisms need to be further investigated. Coprococcus 1 belongs to the Lachnospiraceae family and can produce SCFAs 36 . SCFAs are the fundamental gut microbial byproducts that are related to microbiome-gut-brain axis function.…”

Section: Discussionmentioning

confidence: 99%

Multi-omics analyses demonstrate the modulating role of gut microbiota on the associations of unbalanced dietary intake with gastrointestinal symptoms in children with autism spectrum disorder

Li,

Liu,

Huang

et al. 2023

Gut Microbes

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Our previous work revealed that unbalanced dietary intake was an important independent factor associated with constipation and gastrointestinal (GI) symptoms in children with autism spectrum disorder (ASD). Growing evidence has shown the alterations in the gut microbiota and gut microbiota-derived metabolites in ASD. However, how the altered microbiota might affect the associations between unbalanced diets and GI symptoms in ASD remains unknown. We analyzed microbiome and metabolomics data in 90 ASD and 90 typically developing (TD) children based on 16S rRNA and untargeted metabolomics, together with dietary intake and GI symptoms assessment. We found that there existed 11 altered gut microbiota (FDR-corrected P-value <0.05) and 397 altered metabolites (P-value <0.05) in children with ASD compared with TD children. Among the 11 altered microbiota, the Turicibacter , Coprococcus 1 , and Lachnospiraceae FCS020 group were positively correlated with constipation (FDR-corrected P-value <0.25). The Eggerthellaceae was positively correlated with total GI symptoms (FDR-corrected P-value <0.25). More importantly, three increased microbiota including Turicibacter , Coprococcus 1 , and Eggerthellaceae positively modulated the associations of unbalanced dietary intake with constipation and total GI symptoms, and the decreased Clostridium sp. BR31 negatively modulated their associations in ASD children (P-value <0.05). Together, the altered microbiota strengthens the relationship between unbalanced dietary intake and GI symptoms. Among the altered metabolites, ten metabolites derived from microbiota ( Turicibacter , Coprococcus 1 , Eggerthellaceae, and Clostridium sp. BR31 ) were screened out, enriched in eight metabolic pathways, and were identified to correlate with constipation and total GI symptoms in ASD children (FDR-corrected P-value <0.25). These metabolomics findings further support the modulating role of gut microbiota on the associations of unbalanced dietary intake with GI symptoms. Collectively, our research provides insights into the relationship between diet, the gut microbiota, and GI symptoms in children with ASD.

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Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris

Cited by 17 publications

References 54 publications

Association between gut microbiota and psoriasis: a bidirectional two-sample Mendelian randomization study

Association between gut microbiota and psoriasis: a bidirectional two-sample Mendelian randomization study

A bibliometrics study on the status quo and hot topics of pathogenesis of psoriasis based on Web of Science

Multi-omics analyses demonstrate the modulating role of gut microbiota on the associations of unbalanced dietary intake with gastrointestinal symptoms in children with autism spectrum disorder

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