Involvement of heparanase in migration of microglial cells

Takahashi, Hiroyuki; Matsumoto, Hiroaki; Smirkin, Anna; Itai, Tomohide; Nishimura, Yoshio; Tanaka, Junya

doi:10.1016/j.bbagen.2007.12.014

Cited by 23 publications

(16 citation statements)

References 38 publications

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“…Total RNA was collected. Then, cDNA was generated from DNase-I-treated RNA by reverse transcription using an oligo-(dT) 15 primer, as previously described (Takahashi et al, 2008). GoTaq DNA polymerase (Promega, Madison, WI, USA) was used to amplify each gene cDNA fragment from cDNA isolated from cultured macrophages.…”

Section: Conventional and Quantitative Real-time Rt-pcr (Qpcr)mentioning

confidence: 99%

Anti-inflammatory effects of noradrenaline on LPS-treated microglial cells: Suppression of NFκB nuclear translocation and subsequent STAT1 phosphorylation

Ishii

Yamaizumi

Kawakami

et al. 2015

Neurochemistry International

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Section: Conventional and Quantitative Real-time Rt-pcr (Qpcr)mentioning

confidence: 99%

Anti-inflammatory effects of noradrenaline on LPS-treated microglial cells: Suppression of NFκB nuclear translocation and subsequent STAT1 phosphorylation

Ishii

Yamaizumi

Kawakami

et al. 2015

Neurochemistry International

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“…Then, cDNA was synthesized as previously described [10]. All genespecific mRNA expression values were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA levels.…”

Section: Quantitative Real-time Rt-pcr (Qpcr)mentioning

confidence: 99%

The ameliorative effects of a hypnotic bromvalerylurea in sepsis

Kikuchi

Nishihara

Kawasaki

et al. 2015

Biochemical and Biophysical Research Communications

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“…D-galacturonic acid-type gem-diamine 1-N-iminosugar 32 inhibits this process in a dose-dependent manner. 48 The transmigration of microglia through BM/ECM appears to be associated with the degradation of HSPG, and this is also inhibited dose dependently by 32. The results suggest the involvement of heparanase in the migration or invasion of microglia or brain macrophages across the BM around the brain vasculature.…”

Section: Inhibition Of Microglial Cell Migrationmentioning

confidence: 99%

“…48 Heparanase activity is correlated with the in vitro transmigration ability of microglia through an artificial basement membrane (BM)/extracellular matrix (ECM) containing HSPGs. D-galacturonic acid-type gem-diamine 1-N-iminosugar 32 inhibits this process in a dose-dependent manner.…”

Section: Inhibition Of Microglial Cell Migrationmentioning

confidence: 99%

Gem-diamine 1-N-iminosugars as versatile glycomimetics: synthesis, biological activity and therapeutic potential

Nishimura

2009

J Antibiot

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Iminosugars, which carry a basic nitrogen in the carbohydrate ring, have attracted increasing interest as new glycomimetics. Gem-diamine 1-N-iminosugars, a new class of iminosugars, have a nitrogen atom in place of the anomeric carbon. Various kinds of 1-N-iminosugars have been synthesized from glyconolactones as a chiral source in a totally stereospecific manner and/or by the convergent strategy from siastatin B, a secondary metabolite of Streptomyces. The protonated form of 1-N-iminosugar mimics the charge at the anomeric position in the transition state of enzymatic glycosidic hydrolysis, resulting in a strong and specific inhibition of glycosidases and glycosyltransferases. They have been recently recognized as a new source of therapeutic drug candidates in a wide range of diseases associated with the carbohydrate metabolism of glycoconjugates, such as tumor metastasis, influenza virus infection, lysosomal storage disorder and so forth.

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Involvement of heparanase in migration of microglial cells

Cited by 23 publications

References 38 publications

Anti-inflammatory effects of noradrenaline on LPS-treated microglial cells: Suppression of NFκB nuclear translocation and subsequent STAT1 phosphorylation

Anti-inflammatory effects of noradrenaline on LPS-treated microglial cells: Suppression of NFκB nuclear translocation and subsequent STAT1 phosphorylation

The ameliorative effects of a hypnotic bromvalerylurea in sepsis

Gem-diamine 1-N-iminosugars as versatile glycomimetics: synthesis, biological activity and therapeutic potential

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