Involvement of histamine H3 receptors in scratching behaviour in mast cell-deficient mice

Hossen, Maria Alejandra; Sugimoto, Yukihiko; Kayasuga, Ryoji; Kamei, Chiaki

doi:10.1046/j.1365-2133.2003.05341.x

Cited by 31 publications

(16 citation statements)

References 27 publications

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“…Nemmar et al (22) reported that the nerve terminals in the afferent neurons contain certain neuropeptides such as substance P and that pretreatment with the histamine-H 3 -receptor agonist imetit prevented a capsaicin-induced substance P release from the C-fibers. Moreover, as previously demonstrated, exogenous substance P at a dose of 100 nmol could induce significant scratching behavior in mast-cell-deficient as well as wild-type mice (9). These findings contributed to the fact that substance P is highly compromised during itching and allergic reactions.…”

Section: Discussionsupporting

confidence: 51%

“…Furthermore, some of our previous experiments clearly demonstrated that when administered locally into the skin of mice, the H 3 antagonists induced allergy symptoms such as pruritus or vessel extravasation (9,17). However, although we assumed that these reactions occurred due to the release of histamine and substance P, which are highly compromised during an allergy, the extent to which these chemical mediators participated in the reactions remains obscure.…”

Section: Discussionmentioning

confidence: 97%

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Role of Substance P on Histamine H3 Antagonist-Induced Scratching Behavior in Mice

et al. 2006

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Abstract. The purpose of the present study was to investigate the involvement of chemical mediators, other than histamine, in the scratching behavior induced by H 3 antagonists. Scratching behavior was induced by the histamine H 3 antagonists iodophenpropit and clobenpropit (10 nmol / site) when they were injected intradermally into the rostral part of the back of mastcell-deficient (WBB6F1 W / W v ) and wild-type (WBB6F1 +/ +) mice. Subsequently, the effect of spantide, a tachykinin NK 1 antagonist, was measured for 60 min. The effects of the H 3 antagonists on in vitro histamine release from rat peritoneal mast cells were also investigated. When spantide was injected intradermally at a dose of 0.5 nmol / site, it significantly inhibited the response. Furthermore, iodophenpropit and clobenpropit (10 −6 -10 −8 M) did not induce histamine release in isolated rat peritoneal mast cells. Our results indicate that substance P is involved in the skin responses elicited by the histamine H 3 antagonists. Moreover, the fact that these histamine H 3 antagonists did not induce significant increases in the histamine release from rat peritoneal mast cells suggests that the histamine H 3 receptor may not be present in the peripheral cells considered in this study.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 97%

Role of Substance P on Histamine H3 Antagonist-Induced Scratching Behavior in Mice

et al. 2006

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“…H 3 R antagonists have been reported to produce pruritus-like effects in mice, possibly mediated by C fibers (Schmelz et al, 1997;Hossen et al, 2003;Sugimoto et al, 2004). Because H 3 R-LI is present on keratinocytes but not on epidermal endings, the former may participate in these effects of H 3 R antagonists.…”

Section: Functional Roles For the H 3 Rmentioning

confidence: 99%

Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: Potential antinociceptive targets

Cannon

Chazot

Hann

et al. 2007

Pain

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Activation of histamine H 3 receptors (H 3 Rs) reduces inflammation and nociception, but the existence of H 3 Rs on peripheral innervation has never been demonstrated. Here we use antibodies to locate H 3 Rs in whisker pads, hairy and glabrous hind paw skin, dorsal root ganglia (DRGs), and spinal cords of rats, wild-type mice, and H 3 R knockout (H 3 KO) mice. Although H 3 Rs have been hypothesized to be on C and sympathetic fibers, H 3 R-like immunoreactivity (H 3 R-LI) was only detected on presumptive periarterial Aδ fibers and on Aβ fibers that terminated in Meissner's corpuscles and as lanceolate endings around hair follicles. The H 3 R-positive periarterial fibers were thin-caliber and coexpressed immunoreactivity for calcitonin gene-related peptide (CGRP), substance P, acid sensing ion channel 3 and 200kD neurofilament protein (NF). H 3 R-LI was also detected on epidermal keratinocytes and Merkel cells, but not on Merkel endings, C fibers, any other Aδ fibers, or sympathetic fibers. In DRGs, H 3 R-LI was preponderantly on medium to large neurons coexpressing NF-LI and mostly CGRP-LI. In dorsal horn, CGRP-positive fibers with and without H 3 R-LI ramified extensively in lamina II; many of the former formed a plexus in lamina V. Low levels of H 3 R-LI were also present on Aβ fibers penetrating superficial and into deeper laminae. The distribution of H 3 R-LI was similar in rats and wild-type mice, but was eliminated or strongly reduced in Aδ fibers and Aβ fibers, respectively, in H 3 KO mice. Taken with recently published behavioral results, the present findings suggest that periarterial, peptidergic, H 3 R-containing Aδ fibers may be sources of high threshold mechanical nociception.

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“…H4R is associated with the induction of itch in mice (50). In addition, H3R is involved in scratching behavior of mice (350). When positron emission tomography was used after histamine application, certain areas of the CNS were found to indeed participate in itch perception by humans (353).…”

Section: F Pruritusmentioning

confidence: 99%

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman¹,

Goerge

Schneider

et al. 2006

Physiological Reviews

556

521

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This review focuses on the role of the peripheral nervous system in cutaneous biology and disease. During the last few years, a modern concept of an interactive network between cutaneous nerves, the neuroendocrine axis, and the immune system has been established. We learned that neurocutaneous interactions influence a variety of physiological and pathophysiological functions, including cell growth, immunity, inflammation, pruritus, and wound healing. This interaction is mediated by primary afferent as well as autonomic nerves, which release neuromediators and activate specific receptors on many target cells in the skin. A dense network of sensory nerves releases neuropeptides, thereby modulating inflammation, cell growth, and the immune responses in the skin. Neurotrophic factors, in addition to regulating nerve growth, participate in many properties of skin function. The skin expresses a variety of neurohormone receptors coupled to heterotrimeric G proteins that are tightly involved in skin homeostasis and inflammation. This neurohormone-receptor interaction is modulated by endopeptidases, which are able to terminate neuropeptide-induced inflammatory or immune responses. Neuronal proteinase-activated receptors or transient receptor potential ion channels are recently described receptors that may have been important in regulating neurogenic inflammation, pain, and pruritus. Together, a close multidirectional interaction between neuromediators, high-affinity receptors, and regulatory proteases is critically involved to maintain tissue integrity and regulate inflammatory responses in the skin. A deeper understanding of cutaneous neuroimmunoendocrinology may help to develop new strategies for the treatment of several skin diseases.

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Involvement of histamine H3 receptors in scratching behaviour in mast cell-deficient mice

Abstract: Our results indicated that intradermal injection of H3 antagonists induces scratching behaviour and that chemical mediators other than histamine seem to be involved in the response.

Cited by 31 publications

References 27 publications

Role of Substance P on Histamine H3 Antagonist-Induced Scratching Behavior in Mice

Role of Substance P on Histamine H3 Antagonist-Induced Scratching Behavior in Mice

Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: Potential antinociceptive targets

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

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