Involvement of histone methylation in the regulation of neuronal death

Zhang, Lei; Zhou, Tao; Su, Yaxin; He, Long; Wang, Zhongcheng

doi:10.1007/s13105-023-00978-w

Cited by 2 publications

(2 citation statements)

References 104 publications

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“…The promotor of the gene driving expression of the Gpx4 gene for example is less methylated in cancer cells contributing to higher levels of the protein in these cells [ 290 ], whereas elevated methylation of GpG islands of Gpx4 and FSP1 leads to diminished protein levels [ 291 ]. Both methylation as well as acetylation of histones regulate susceptibility of cells towards ferroptosis [ 292 , 293 ], e.g. acetylation of K27 on histone 3 of the Gpx4 encoding gene increased its transcription [ 293 ].…”

Section: Regulation Of Ferroptosismentioning

confidence: 99%

Ferroptosis in health and disease

Berndt,

Alborzinia,

Amen

et al. 2024

Redox Biology

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Section: Regulation Of Ferroptosismentioning

confidence: 99%

Ferroptosis in health and disease

Berndt,

Alborzinia,

Amen

et al. 2024

Redox Biology

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“…Compared to the ferroptosis specific molecular markers GPX4, prostaglandin-endoperoxidesynthase2, solute carrier family 7 member 11 (SLC7A11), acyl-CoA synthetase long-chain family member 4, regulator of G-protein signaling 4, single stranded DNA binding protein 1 (SSBP1) [ 28 ], it has been observed that ferritinophagy controls disturbed protein mechanisms encoding and regulating iron transcripts, including differences in miRNA, methylation and acetylation [ 29 ]. Histone ubiquitination, methylation, miRNA, and the immune microenvironment also modulate ferroptosis in cancer cells [ 30 – 33 ].…”

Section: Main Textmentioning

confidence: 99%

Ferritinophagy: research advance and clinical significance in cancers

Wang,

Wu,

Peng

et al. 2023

Cell Death Discov.

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Ferritinophagy, a process involving selective autophagy of ferritin facilitated by nuclear receptor coactivator 4 (NCOA4), entails the recognition of ferritin by NCOA4 and subsequent delivery to the autophagosome. Within the autophagosome, ferritin undergoes degradation, leading to the release of iron in the lysosome. It is worth noting that excessive iron levels can trigger cell death. Recent evidence has elucidated the significant roles played by ferritinophagy and ferroptosis in regulation the initiation and progression of cancer. Given the crucial role of ferritinophagy in tumor biology, it may serve as a potential target for future anti-tumor therapeutic interventions. In this study, we have provided the distinctive features of ferritinophagy and its distinctions from ferroptosis. Moreover, we have briefly examined the fundamental regulatory mechanisms of ferritinophagy, encompassing the involvement of the specific receptor NCOA4, the Nrf2/HO-1 signaling and other pathways. Subsequently, we have synthesized the current understanding of the impact of ferritinophagy on cancer progression and its potential therapeutic applications, with a particular emphasis on the utilization of chemotherapy, nanomaterials, and immunotherapy to target the ferritinophagy pathway for anti-tumor purposes.

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Involvement of histone methylation in the regulation of neuronal death

Cited by 2 publications

References 104 publications

Ferroptosis in health and disease

Ferroptosis in health and disease

Ferritinophagy: research advance and clinical significance in cancers

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