Involvement of IFNβ on IFNγ and nitric oxide (NO) production by bone marrow (BM) cells in response to lipopolysaccharide

Campillo, José A.; Peláez, Blondineth; Angulo, Iñigo; Bensussan, Armand; Subiza, José Luis

doi:10.1016/j.biopha.2006.07.085

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Myeloid cells are able to release NO in response to IFN-γ30313233; moreover, IFN-γ and NO-producing myeloid cells have been described in cancer34. Therefore, we investigated the ability of γIMCs to produce NO in response to GAS.…”

Section: Resultsmentioning

confidence: 99%

Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections

et al. 2012

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Cytokine-activated neutrophils are known to be essential for protection against group A Streptococcus infections. However, during severe invasive group A Streptococcus infections that are accompanied by neutropenia, it remains unclear which factors are protective against such infections, and which cell population is the source of them. Here we show that mice infected with severe invasive group A Streptococcus isolates, but not with non-invasive group A Streptococcus isolates, exhibit high concentrations of plasma interferon-γ during the early stage of infection. Interferon-γ is necessary to protect mice, and is produced by a novel population of granulocyte–macrophage colony-stimulating factor-dependent immature myeloid cells with ring-shaped nuclei. These interferon-γ-producing immature myeloid cells express monocyte and granulocyte markers, and also produce nitric oxide. The adoptive transfer of interferon-γ-producing immature myeloid cells ameliorates infection in wild-type and interferon-γ-deficient mice. Our results indicate that interferon-γ-producing immature myeloid cells have a protective role during the early stage of severe invasive group A Streptococcus infections.

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