Involvement of IL-10 and granulocyte colony-stimulating factor in the fate of monocytes controlled by galectin-1

Cheng, Da-En; Chang, Wei‐An; Hung, Jen‐Yu; Huang, Ming‐Shyan; Kuo, Po‐Lin

doi:10.3892/mmr.2014.2573

Cited by 9 publications

(4 citation statements)

References 42 publications

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“…Gene expression analysis showed that exposure to diabetic EVs resulted in upregulation of antiapoptotic genes in monocytes. As apoptosis regulation is a major factor in monocyte differentiation to dendritic cells (32), decreased apoptosis driven by diabetic EVs may result in increased monocyte differentiation.…”

Section: Discussionmentioning

confidence: 99%

Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes

et al. 2018

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Type 2 diabetes is a chronic age-associated degenerative metabolic disease that reflects relative insulin deficiency and resistance. Extracellular vesicles (EVs) (exosomes, microvesicles, and apoptotic bodies) are small (30-400 nm) lipid-bound vesicles capable of shuttling functional proteins, nucleic acids, and lipids as part of intercellular communication systems. Recent studies in mouse models and in cell culture suggest that EVs may modulate insulin signaling. Here, we designed cross-sectional and longitudinal cohorts of euglycemic participants and participants with prediabetes or diabetes. Individuals with diabetes had significantly higher levels of EVs in their circulation than euglycemic control participants. Using a cell-specific EV assay, we identified that levels of erythrocyte-derived EVs are higher with diabetes. We found that insulin resistance increases EV secretion. Furthermore, the levels of insulin signaling proteins were altered in EVs from individuals with high levels of insulin resistance and β-cell dysfunction. Moreover, EVs from individuals with diabetes were preferentially internalized by circulating leukocytes. Cytokine levels in the media and in EVs were higher from monocytes incubated with diabetic EVs. Microarray of these leukocytes revealed altered gene expression pathways related to cell survival, oxidative stress, and immune function. Collectively, these results suggest that insulin resistance increases the secretion of EVs, which are preferentially internalized by leukocytes, and alters leukocyte function.

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Section: Discussionmentioning

confidence: 99%

Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes

et al. 2018

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“…Galectin 1 was the first discovered protein from the glycan-binding family. Its overexpression in several tumors is related to the metastasis [82]. Recent studies have determined that higher secreted amounts of Galectin 1 by lung cancer cells can alter the phenotypes of MoDCs and impair all reactive T cell response by regulating the activity of the inhibitor of DNA binding 3 (ID3), which can induce IL-10 autocrine [83].…”

Section: Drivers Of DC Anergy In Lung Cancermentioning

confidence: 99%

Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives

Wang

Huang

2019

Cancer Communications

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Lung cancer is the leading cause of cancer mortality worldwide. Dendritic cells (DCs) are the key factors providing protective immunity against lung tumors and clinical trials have proven that DC function is reduced in lung cancer patients. It is evident that the immunoregulatory network may play a key role in the failure of the immune response to terminate tumors. Lung tumors likely employ numerous strategies to suppress DC-based anti-tumor immunity. Here, we summarize the recent advances in our understanding on lung tumor-induced immunosuppression in DCs, which affects the initiation and development of T-cell responses. We also describe which existing measures to restore DC function may be useful for clinical treatment of lung tumors. Furthering our knowledge of how lung cancer cells alter DC function to generate a tumor-supportive environment will be essential in order to guide the design of new immunotherapy strategies for clinical use.

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“… 49 Adding to this, G-CSF has been proven experimentally to modulate monocyte cytokine secretion. 50 , 51 The exact mechanism of action should be subjected to further studies since such clinical observation has the potential to furnish a new insight in the fields of immunology and molecular biology along with its clinical applications.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Prognostic Role of Monocytopenia in Chemotherapy-Induced Febrile Neutropenia Patients Treated with Granulocyte Colony-Stimulating Factor

Alshari

Zu’bi

Sharie

et al. 2021

TCRM

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Objective: Chemotherapy-induced febrile neutropenia is a common and serious oncological emergency which carries a substantial mortality and morbidity. The main objective of this study is to evaluate the usage of absolute monocyte count (AMC) at presentation as a prognostic factor for patients with chemotherapy-induced febrile neutropenia who were subsequently treated with granulocyte colony-stimulating factor (G-CSF). Study Design: The electronic medical records of our center were used retrospectively to identify patients diagnosed with unprecedented chemotherapy-induced febrile neutropenia treated with G-CSF between January 2010 to December 2020 and diagnosed with solid and hematological malignancies. Patient's demographics, disease characteristics and laboratory investigations were extracted. Disease progression measures were statistically compared between the study groups in the short-term period of follow-up (six days) including absolute neutrophil count (ANC), ANC difference compared to the baseline readings, hospitalization period, and mortality. Results: A total of 80 patients were identified and categorized into two groups namely monocytopenia (n = 34) and non-monocytopenia (n = 46) with an AMC cutoff point of 0.1×10 9 cells/L. The monocytopenia group exhibited a worse prognosis with lower ANC values and slower improvement illustrated by the low ANC difference values at all follow up points (P-value ≤ 0.05) apart from day 5. A statistically significant lower hospitalization period was also observed in the non-monocytopenia group (P-value = 0.006). Linear regression analysis evaluated the association between AMC values at admission and ANC values at admission along with subsequent days of follow up which were found to be statistically significant (P-value ≤ 0.05). Receiver operating characteristic curves suggest a satisfactory predictability of ANC changes by AMC values at admission, days1, 2, 3, 4 and 6. Conclusion: Monocytopenia holds a worse prognosis in chemotherapy-induced febrile neutropenia patients treated with G-CSF. In addition, AMC values at presentation represents a potential risk factor that can predict short-term changes regarding ANC measures.

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Involvement of IL-10 and granulocyte colony-stimulating factor in the fate of monocytes controlled by galectin-1

Cited by 9 publications

References 42 publications

Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes

Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes

Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives

Evaluating the Prognostic Role of Monocytopenia in Chemotherapy-Induced Febrile Neutropenia Patients Treated with Granulocyte Colony-Stimulating Factor

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