Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability

Aureli, Anna; Sebastiani, Pierluigi; Beato, Tiziana Del; Marimpietri, A; Graziani, Andrea; Sechi, Enzo; Loreto, Silvia Di

doi:10.1016/j.imlet.2014.08.003

Cited by 21 publications

(21 citation statements)

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“…Also, elevated levels of IL6 have been found in Bipolar disorder, Schizophrenia and Intellectual Disability (Brietzke et al, 2011;Potvin et al, 2008;Sasayama et al, 2013;Aureli et al, 2014). Accordingly, we found strong positive correlations between IL6 À174G frequency and 2004 WHO DALYs for Bipolar Disorder (r 81 = 0.800, P < 0.001) and for Schizophrenia (r 81 = 0.653, P < 0.001).…”

Section: Global Il6 à174g > C Rs1800795 Frequencies Correlate With Nasupporting

confidence: 58%

“…Consistent with this evidence, elevated levels of IL6 have been found in Bipolar disorder, Schizophrenia and Intellectual Disability (Brietzke et al, 2011;Potvin et al, 2008;Sasayama et al, 2013;Aureli et al, 2014). Additionally, higher IL6 concentrations have been associated with an increased rate of cognitive decline in both executive function and memory function among the elderly (Mooijaart et al, 2013).…”

Section: Introductionmentioning

confidence: 53%

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Infectious diseases, IL6 −174G > C polymorphism, and human development

Napolioni

MacMurray²

2016

Brain, Behavior, and Immunity

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Section: Global Il6 à174g > C Rs1800795 Frequencies Correlate With Nasupporting

confidence: 58%

Section: Introductionmentioning

confidence: 53%

Infectious diseases, IL6 −174G > C polymorphism, and human development

Napolioni

MacMurray²

2016

Brain, Behavior, and Immunity

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“…In patients with ID, higher level of interleukin (IL)-6 and IL-10 were observed. [21–23] Genetic abnormalities of IL-1 receptor among patients with X-linked ID were reported. [24–26] Cytokines are responsible for signaling and can affect hypothalamic–pituitary–adrenal axis and the function of glia in the developing brain.…”

Section: Discussionmentioning

confidence: 99%

Increase the risk of intellectual disability in children with scabies

et al. 2017

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Scabies is a common and distressing disease caused by the mite Sarcoptes scabiei var. hominis. Psychiatric disorder in childhood is an important disease and easily neglected. There are several similarities in scabies and psychiatric disorders in childhood (PDC). Both of them may present with pruritus. They are relatively common in patients with lower socioeconomic status and crowded environment. Furthermore, immune-mediated inflammatory processes play a role in the pathophysiology in both diseases. An association between scabies and psychiatric disorders may exist. This nationwide population-based cohort study utilized data from the National Health Insurance Research Database to investigate the relationship between scabies and PDC. A total of 2137 children with scabies were identified as the study group and 8548 age- and sex-matched children were selected as the control group. A total of 607 (5.68%) children developed PDC during the 7-year follow-up period. The overall incidences of PDC are similar but patients with scabies had a higher risk of developing intellectual disability (ID) (scabies group vs control group: 1.3% vs 0.6%, adjusted hazard ratio: 2.04 and 95% confidence interval: 1.25–3.32). The immune-mediated inflammatory processes of both diseases were reviewed and may contribute to the 104% increased risk of interleukin in patients with scabies. We suggest a more comprehensive management in treating patients with scabies or ID. Early and comprehensive treatment of scabies and other risk factors may decrease the risk of subsequent ID. When we approach patients with ID, concurrent evaluation of scabies and other risk factors may contribute to successful management.

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“…All 3 ID Gipsy siblings presented the specific IL-6 (-174) G/C and the IL-1RA mspa11100 T/T genotypes both associated with an increased risk to develop ID [17] and the IL6 GG/CA predisposing aplotype [17].…”

Section: Patientmentioning

confidence: 99%

“…Cytokine gene polymorphisms were investigated in patients and controls using the Pel-Freez Cytokine Genotyping Kit [17].…”

Section: Patientmentioning

confidence: 99%

Potential Biomarkers for Intellectual Disability: A Gipsy Family Study

T¹

2014

Hereditary Genet

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Intellectual disability (ID) is frequently due to the synergic action of environmental and genetic factors. Here we describe the particular case of three Gipsy Italian siblings, fifteen, twelve and eleven years old, with ID. Genetic analysis stated that the parents are not consanguineous, and no human leukocyte antigen (HLA) alleles related to autism and/or other neurological disorders are present in the 3 ID patients. Instead, a positive association of ID with brain derived neurotrophic factor (BDNF) (Val66Met and C270T), IL6 (-174) and interleukin 1receptor antagonist (IL1RA) mspa 11100 polymorphisms was demonstrated in these three ID patients. Moreover, serum levels of interleukin 1beta (IL1β), interleukin 6 (IL6) were significantly different between the three patients and controls.

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Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability

Cited by 21 publications

References 50 publications

Infectious diseases, IL6 −174G > C polymorphism, and human development

Infectious diseases, IL6 −174G > C polymorphism, and human development

Increase the risk of intellectual disability in children with scabies

Potential Biomarkers for Intellectual Disability: A Gipsy Family Study

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