2007
DOI: 10.1248/bpb.30.1324
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Involvement of Inducible Nitric Oxide Synthase in Blood Flow Decrease in Vein Induced by Hen-Egg White Lysozyme

Abstract: Our in vivo assay system was developed to quantitatively estimate mouse hen-egg white lysozyme (HEL)-anaphylaxis, including fatal shock.1) This assay system monitors the decrease in blood pressure 2) or blood flow 3) as anaphylaxis response and makes possible investigation of the dynamics of the anaphylactic response in the same individual animals without killing them. We have also discovered a distinctive phenomenon in which the blood flow of vein microcirculation is markedly decreased by HEL-sensitization al… Show more

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Cited by 12 publications
(16 citation statements)
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“…4,5) This paper describes the evaluation of the allergy-preventive effects of a 35% EtOH extract (IT) of the flowers of I. textori and compounds (1-7) previously isolated from IT.…”
Section: 3)mentioning
confidence: 99%
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“…4,5) This paper describes the evaluation of the allergy-preventive effects of a 35% EtOH extract (IT) of the flowers of I. textori and compounds (1-7) previously isolated from IT.…”
Section: 3)mentioning
confidence: 99%
“…4) Additionally, the blood flow decrease occurs via both pathways of the iNOS-independent and -dependent response. 5) Therefore this monitoring system should be useful for searching for preventive substances against complicated allergy involving NO, TXA 2 , PGI 2 , ET-1, GE, COX-1, and COX-2. 4,5) This paper describes the evaluation of the allergy-preventive effects of a 35% EtOH extract (IT) of the flowers of I. textori and compounds (1-7) previously isolated from IT.…”
mentioning
confidence: 99%
“…As stress is an important factor affecting blood flow (BF), we have developed a new assay system based upon our findings [1][2][3] on BF decrease in the induction phase of allergy in the tail vein of mice sensitized by use of hen egg-white lysozyme (HEL). We previously developed an in vivo assay to search natural resources for allergy-preventive substances.…”
mentioning
confidence: 99%
“…We used it to assess BF during the allergy induction phase in the tail veins of mice that have been sensitized to HEL. [1][2][3] Blood flow in the model appears to be regulated by various factors such as nitric oxide, thromboxane A 2 (TXA 2 ), prostacyclin (PGI 2 ), and endothelin-1 (ET-1) together with cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and constitutive nitric oxide synthase (cNOS). 1) A reduction of BF occurs via two pathways.…”
mentioning
confidence: 99%
“…5) Additionally, the blood flow decrease occurs via both pathways of iNOS-independent and -dependent response. 6) Therefore, this monitoring system should be useful for searching for preventive substances against complicated allergy involving NO, COX-1, 2, TXA 2 , ET-1 and PGI 2 . 5,6) This paper describes the evaluation of the allergy-preventive effects of the methanol extracts (HM) of the petals of H. mutabilis 'versicolor' and isolated compounds from HM, and the structure of a new flavonoid glycoside, which we have named mutabiloside (1), together with four known compounds (2-5).…”
mentioning
confidence: 99%