Involvement of inflammatory cells in chronic rhinosinusitis with nasal polyps

Enache, Irina; Ioniță, Elena; Anghelina, Florin; Mogoantă, Carmen Aurelia; Ciolofan, Mircea Sorin; Căpitănescu, Alina Nicoleta; Vîlcea, Alina Maria; Florescu, Anamaria; Simionescu, Cristiana

doi:10.47162/rjme.61.3.25

Cited by 5 publications

(5 citation statements)

References 37 publications

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“…According to Enache et al 40 the pathological feature of nasal polyp includes the heterogeneity of epithelial and stromal changes. Stromal changes were represented by edema and inflammatory cells infiltration.…”

Section: Discussionmentioning

confidence: 99%

Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage

Bao

Liu

Jiang

et al. 2023

Immunity Inflam & Disease

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Background and Aim Small ubiquitin–like modifier (SUMO)‐specific protease (SENP)3 is a protease molecule that responds to reactive oxygen species (ROS) with high sensitivity. However, the role of ROS and SENP3 in the formation of nasal polyps (NPs) remains unclear. This study aimed to explore how SENP3 influenced the outcome of chronic rhinosinusitis (CRS) by altering macrophage function, that is, the formation of NPs. Methods The alternative activation of macrophage (M2) was detected with CD68 + CD206 + in humans and CD206 + in mice. The nasal mucosa of patients with CRS was tested using flow cytometry (CD68, CD80, and CD206) and triple‐color immunofluorescence staining (CD68, CD206, and SENP3). The bone marrow–derived macrophages from SENP3 knockout and control mice were stimulated with interleukin (IL)‐4 and IL‐13 to analyze alternative macrophage polarization in vitro. An animal model of allergic rhinitis was constructed using SENP3 knockout mice. CD206 was detected by immunofluorescence staining. The thickening of eosinophil‐infiltrated mucosa was detected by Luna staining. Results The number of CD68 + CD206 + M2 increased in the nasal mucosa of patients with CRS with NP (CRSwNP) compared with patients with CRS without NP (CRSsNP), but with no significant difference between the groups. SENP3 knockout increased the polarization of F4/80 + CD206 + M2. Meanwhile, the number of CD206 + M2 significantly increased in the allergic rhinitis model constructed using SENP3 knockout mice and controls, with a more obvious proliferation of the nasal mucosa. Conclusion Downregulation of SENP3 promotes the formation of nasal polyps mediated by increasing alternative activated macrophage in nasal mucosal inflammation.

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Section: Discussionmentioning

confidence: 99%

Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage

Bao

Liu

Jiang

et al. 2023

Immunity Inflam & Disease

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“…Occasionally, the symptomatology is similar to that of an inflammatory rhinopharyngeal condition; in other cases, it mimics a tumoral nasal congestion, entailing a thorough clinical examination and urgent diagnostic imaging [22][23][24].…”

Section:  Discussionmentioning

confidence: 99%

Current approach of juvenile nasopharyngeal angiofibroma: a case series

Vlăescu

Ioniță²,

Ciolofan³

et al. 2022

Rom J Morphol Embryol

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“…Histologically, they exhibit many similar features, but the presence of more glandular proliferation of varied sizes, basement membrane thickening, and goblet cell metaplasia in our case favored the diagnosis of REAH. Histopathology of inflammatory nasal polyps reveals edematous stroma with inflammatory cell infiltrates, primarily eosinophils, lymphocytes, plasma cells, and mast cells, and histopathology also shows seromucinous gland proliferation [14]. Hence, it is significant to differentiate inflammatory polyps from REAH.…”

Section: Figure 1: Gross Polypoidal Edematous and Glistening Appearan...mentioning

confidence: 99%

Respiratory Epithelial Adenomatoid Hamartoma in a Young Female: A Diagnostic Dilemma

Mujeeb,

Singavarapu,

Chaganti

et al. 2023

Cureus

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Hamartomas are non-neoplastic tissue abnormalities commonly found in various organs but rarely in the upper aerodigestive tract. Respiratory epithelial adenomatoid hamartoma (REAH) is a rare benign proliferation affecting the nasal cavity and sinonasal tract. It often mimics other nasal masses, leading to diagnostic challenges. We present the case of a 25-year-old female with recurrent epistaxis and chronic bilateral nasal obstruction. Diagnostic endoscopy revealed a polypoidal mass, later confirmed as REAH through histopathological examination. CT scans demonstrated soft tissue opacity but no erosion of surrounding bony structures. The patient underwent endoscopic excision, and the excised mass exhibited characteristic histological features of REAH. Endoscopic excision with careful postoperative follow-up can lead to successful outcomes in REAH cases. A year of follow-up revealed no recurrence.

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Involvement of inflammatory cells in chronic rhinosinusitis with nasal polyps

Cited by 5 publications

References 37 publications

Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage

Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage

Current approach of juvenile nasopharyngeal angiofibroma: a case series

Respiratory Epithelial Adenomatoid Hamartoma in a Young Female: A Diagnostic Dilemma

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