Involvement of insulin resistance in normoglycaemic obese patients with periodontitis: A cross‐sectional study

Martínez-Herrera, Mayte; Silvestre, Francisco-Javier; Silvestre‐Rangil, Javier; Bañuls, Celia; Rocha, Milagros; Hernández‐Mijares, Antonio

doi:10.1111/jcpe.12773

Cited by 20 publications

(21 citation statements)

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“…Furthermore, the higher values in inflammatory parameters observed in obese may probably be due to a combination of metabolic and inflammatory profiles and neglected attitudes towards oral hygiene. [24][25][26] In the present study, increased crestal bone destruction was observed in obese patients that showed significant difference with non-obese individuals. 17,23 In a recent study by Maciel et al 17 Recent investigations have confirmed that obese patients are more susceptible to periodontal attachment loss with increased alveolar bone destruction and is associated with poor periodontal therapy response due to systemic inflammation.…”

Section: Discussionsupporting

confidence: 53%

Comparison of clinical and radiographic peri‐implant parameters among obese and non‐obese patients: A 5‐year study

Alkhudhairy

Vohra

Al‐Kheraif

et al. 2018

Clin Implant Dent Rel Res

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Section: Discussionsupporting

confidence: 53%

Comparison of clinical and radiographic peri‐implant parameters among obese and non‐obese patients: A 5‐year study

Alkhudhairy

Vohra

Al‐Kheraif

et al. 2018

Clin Implant Dent Rel Res

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“…adipokines play a critical role, affecting periodontal tissue and directly contributing to the pathogenesis and extent of periodontitis (Genco et al, 2005;Marchetti et al, 2012). In a previous study carried out by our group (Martinez-Herrera et al, 2017), we have observed a high prevalence of periodontitis in our obese (80.9%) vs lean (41.2%) population. Moreover, we have determined that the risk of periodontitis in our population increased by 8% for every kg/m 2 of BMI, which is in line with previous reports (Ekuni et al, 2008).…”

Section: Discussionmentioning

confidence: 53%

“…This study analysed a total of 231 subjects (64 men and 167 women) recruited between September 2015 and December 2016. The participants were divided into four groups according to BMI in lean and obese patients and diagnosed with or without CP: lean subjects without CP (n = 64), lean patients with CP (n = 48), obese subjects without CP (n = 23) and obese patients with CP (n = 96), which is in accordance with the high prevalence of periodontitis we had previously reported in our obese population (Martinez-Herrera et al, 2017).…”

Section: Resultsmentioning

confidence: 73%

“…In this sense, it has been suggested that IR plays a role in the pathogenesis of periodontitis (Genco, Grossi, Ho, Nishimura, & Murayama, ). In fact, we have recently shown that periodontitis tends to be more extensive in obese patients with IR than in their respective counterparts without IR (Martinez‐Herrera et al., ).…”

Section: Introductionmentioning

confidence: 94%

“…. In fact, we have recently shown that periodontitis tends to be more extensive in obese patients with IR than in their respective counterparts without IR (Martinez-Herrera et al, 2017).…”

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confidence: 95%

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Levels of serum retinol‐binding protein 4 before and after non‐surgical periodontal treatment in lean and obese subjects: An interventional study

Martínez-Herrera

Silvestre

Silvestre‐Rangil

et al. 2017

J Clinic Periodontology

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Gingival inflammation and leukocyte–endothelium cell interactions in women with polycystic ovary syndrome

Márquez‐Arrico,

Silvestre,

Fernández‐Reyes

et al. 2024

Journal of Periodontology

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BackgroundGiven the link between chronic inflammation and periodontal pathologies and increased cardiovascular risk, this study aims to investigate if gingivitis exacerbates the inflammatory response and subclinical atherosclerotic markers in women with polycystic ovary syndrome (PCOS).MethodsFor this case–control study, women were assigned to three groups: two PCOS groups (with and without gingivitis) and a control group. Anthropometric and biochemical variables were determined, along with periodontal parameters (probing pocket depth [PPD], clinical attachment level [CAL], bleeding on probing [BOP], plaque index, calculus index, and tooth loss), systemic and neutrophil inflammatory markers (tumor necrosis factor alpha [TNFα], C‐reactive protein [CRP], and c‐Jun N‐terminal kinase [JNK]), systemic oxidative stress mediators (myeloperoxidase [MPO] and glutathione), soluble cellular adhesion molecules, and neutrophil–endothelium cell interactions (rolling flux, velocity, and adhesion).ResultsOf 104 women recruited, 68 had PCOS, 24 of whom presented gingivitis, and 36 were controls. PCOS patients presented altered sexual hormone, lipid, and carbohydrate profiles. Levels of systemic inflammatory markers, MPO, and soluble platelet selectin (sP‐selectin) were higher, and glutathione levels were lower in PCOS patients. BOP, plaque, and calculus index values were higher in PCOS patients with gingivitis. Neutrophils from PCOS patients showed increased JNK and decreased adhesion under flow conditions, with reduced rolling velocity and increased rolling flux and cellular adhesion, all of which were more pronounced in those with gingivitis. BOP was independently associated with rolling velocity, rolling flux, and cellular adhesion.ConclusionNeutrophils of PCOS patients with gingivitis exhibit hyperactivity, promoting interaction with the endothelium and potentially contributing to atherosclerotic disease.Plain Language SummaryCurrently, there is a high prevalence of diseases that affect tooth‐supporting tissues (periodontal diseases) and negatively influence the oral health and quality of life of the adult population. These pathologies lead to movement of the teeth and impairment of chewing function, eventually resulting in the loss of teeth. In recent years, the concept of periodontal medicine has arisen and consists of studying how periodontal diseases can influence our general inflammatory system and how systemic inflammatory pathologies can affect our oral health. In the present study, we evaluate a group of women with polycystic ovary syndrome (PCOS), a condition characterized by alterations of sex hormones and lipid profile and weight gain (body mass index). Our results show a high prevalence of gum inflammation among women with PCOS, which affects the interaction of their leukocytes and endothelial cells. The leukocytes of these women are hyper‐responsive, presenting greater endothelial adhesion, lower flow velocity and enhanced rolling compared to those in a PCOS group without gum inflammation or controls. This study has generated a new line of research to analyze how neutrophils from patients with gingivitis exhibit hyperactivity, which promotes their interaction with the endothelium, thus contributing to the development of atherosclerotic disease.

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Involvement of insulin resistance in normoglycaemic obese patients with periodontitis: A cross‐sectional study

Abstract: Our data support an association between obesity and periodontitis, and point to a central role of IR. Periodontitis tends to be more extensive in obese patients with IR.

Cited by 20 publications

References 40 publications

Comparison of clinical and radiographic peri‐implant parameters among obese and non‐obese patients: A 5‐year study

Comparison of clinical and radiographic peri‐implant parameters among obese and non‐obese patients: A 5‐year study

Levels of serum retinol‐binding protein 4 before and after non‐surgical periodontal treatment in lean and obese subjects: An interventional study

Gingival inflammation and leukocyte–endothelium cell interactions in women with polycystic ovary syndrome

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