Involvement of integrin-activating peptides derived from tenascin-C in colon cancer progression

Fujita, Motomichi; Suzuki, Hideo; Fukai, Fumio

doi:10.4251/wjgo.v13.i9.980

Cited by 3 publications

(3 citation statements)

References 119 publications

(143 reference statements)

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“…These fragments in turn can regulate a wide array of biological processes, including angiogenesis, cell migration, adhesion and differentiation as well as tumor growth and metastasis [ 323 ]. It was found that matrikines can originate from collagen [ 324 , 325 ], elastin [ 326 , 327 ], tenascin [ 328 , 329 ], fibronectin [ 330 , 331 ], laminins [ 332 ], decorin, thrombospondin and versican [ 333 ].…”

Section: Degradation Of the Tumourigenic Matrixmentioning

confidence: 99%

The Functional Role of Extracellular Matrix Proteins in Cancer

Popova

Jücker

2022

Cancers

126

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The extracellular matrix (ECM) is highly dynamic as it is constantly deposited, remodeled and degraded to maintain tissue homeostasis. ECM is a major structural component of the tumor microenvironment, and cancer development and progression require its extensive reorganization. Cancerized ECM is biochemically different in its composition and is stiffer compared to normal ECM. The abnormal ECM affects cancer progression by directly promoting cell proliferation, survival, migration and differentiation. The restructured extracellular matrix and its degradation fragments (matrikines) also modulate the signaling cascades mediated by the interaction with cell-surface receptors, deregulate the stromal cell behavior and lead to emergence of an oncogenic microenvironment. Here, we summarize the current state of understanding how the composition and structure of ECM changes during cancer progression. We also describe the functional role of key proteins, especially tenascin C and fibronectin, and signaling molecules involved in the formation of the tumor microenvironment, as well as the signaling pathways that they activate in cancer cells.

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Section: Degradation Of the Tumourigenic Matrixmentioning

confidence: 99%

The Functional Role of Extracellular Matrix Proteins in Cancer

Popova

Jücker

2022

Cancers

126

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“…It can provide a permissive environment for cancer cells to move through the ECM and invade surrounding tissues. TNC has also been associated with epithelial-mesenchymal transition (EMT), a process linked to increased cancer cell motility and invasiveness [ 50 ]. The ELK3 gene, also known as NET (Nuclear Protein Related to SAM Pointed Domain-Containing ETS Transcription Factor), has been found to play roles in cancer development and progression [ 51 – 53 ].…”

Section: Discussionmentioning

confidence: 99%

Establishment and validation of an immune infiltration predictive model for ovarian cancer

Song,

Zhang,

Sun

et al. 2023

BMC Med Genomics

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Background The most prevalent mutation in ovarian cancer is the TP53 mutation, which impacts the development and prognosis of the disease. We looked at how the TP53 mutation associates the immunophenotype of ovarian cancer and the prognosis of the disease. Methods We investigated the state of TP53 mutations and expression profiles in culturally diverse groups and datasets and developed an immune infiltration predictive model relying on immune-associated genes differently expressed between TP53 WT and TP53 MUT ovarian cancer cases. We aimed to construct an immune infiltration predictive model (IPM) to enhance the prognosis of ovarian cancer and investigate the impact of the IPM on the immunological microenvironment. Results TP53 mutagenesis affected the expression of seventy-seven immune response-associated genes. An IPM was implemented and evaluated on ovarian cancer patients to distinguish individuals with low- and high-IPM subgroups of poor survival. For diagnostic and therapeutic use, a nomogram is thus created. According to pathway enrichment analysis, the pathways of the human immune response and immune function abnormalities were the most associated functions and pathways with the IPM genes. Furthermore, patients in the high-risk group showed low proportions of macrophages M1, activated NK cells, CD8+ T cells, and higher CTLA-4, PD-1, PD-L1, and TIM-3 than patients in the low-risk group. Conclusions The IPM model may identify high-risk patients and integrate other clinical parameters to predict their overall survival, suggesting it is a potential methodology for optimizing ovarian cancer prognosis.

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“…The variants containing FNIII A1A2 repeats also inhibit T cell activation in vitro, suggesting that TNC exerts immunosuppressive activity [ 151 ]. Additionally, work from our laboratory has shown that TNC harbors a functional cryptic site that comprises the YTITIRGV amino acid sequence located in the FN type III A2 repeat, and fragments containing this sequence, termed TNIIIA2 peptide, can potently enhance cell adhesion by activating β1-integrins; this activation state is sustained for an extended period [ 152 ]. Based on these functions, TNIIIA2 contributes to the ability of cancer cells to acquire malignant properties, including hyper-proliferation, disseminative migration, anchorage-independent growth, and anoikis resistance [ 153 , 154 , 155 , 156 , 157 ].…”

Section: Matricellular Proteins In Cellular Senescencementioning

confidence: 99%

Involvement of Matricellular Proteins in Cellular Senescence: Potential Therapeutic Targets for Age-Related Diseases

Fujita,

Sasada,

Iyoda

et al. 2024

IJMS

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Senescence is a physiological and pathological cellular program triggered by various types of cellular stress. Senescent cells exhibit multiple characteristic changes. Among them, the characteristic flattened and enlarged morphology exhibited in senescent cells is observed regardless of the stimuli causing the senescence. Several studies have provided important insights into pro-adhesive properties of cellular senescence, suggesting that cell adhesion to the extracellular matrix (ECM), which is involved in characteristic morphological changes, may play pivotal roles in cellular senescence. Matricellular proteins, a group of structurally unrelated ECM molecules that are secreted into the extracellular environment, have the unique ability to control cell adhesion to the ECM by binding to cell adhesion receptors, including integrins. Recent reports have certified that matricellular proteins are closely involved in cellular senescence. Through this biological function, matricellular proteins are thought to play important roles in the pathogenesis of age-related diseases, including fibrosis, osteoarthritis, intervertebral disc degeneration, atherosclerosis, and cancer. This review outlines recent studies on the role of matricellular proteins in inducing cellular senescence. We highlight the role of integrin-mediated signaling in inducing cellular senescence and provide new therapeutic options for age-related diseases targeting matricellular proteins and integrins.

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Involvement of integrin-activating peptides derived from tenascin-C in colon cancer progression

Cited by 3 publications

References 119 publications

The Functional Role of Extracellular Matrix Proteins in Cancer

The Functional Role of Extracellular Matrix Proteins in Cancer

Establishment and validation of an immune infiltration predictive model for ovarian cancer

Involvement of Matricellular Proteins in Cellular Senescence: Potential Therapeutic Targets for Age-Related Diseases

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