Involvement of local adrenergic receptors in the process of ovulation in gonadotrophin-primed immature rats

Kannisto, Päivi; Owman, Ch.; Walles, B.

doi:10.1530/jrf.0.0750357

Cited by 36 publications

(15 citation statements)

References 19 publications

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“…Several studies of rodents and goldfish have indicated that certain dopaminergic medications affect the release of gonadotropins and prolactin [24,[53][54][55][56], which may play a role in ovarian carcinogenesis. Human studies have also shown that stimulation of dopaminergic receptors is involved in the release of luteinizing hormone, follicle-stimulating hormone, and prolactin [11,[57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Association between antidepressant medication use and epithelial ovarian cancer risk: a systematic review and meta‐analysis of observational studies

Huo

Qiao

Gao

2018

Brit J Clinical Pharma

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AIMThe aim of this paper is to clarify the inconsistent findings in the association between antidepressant use and the risk of epithelial ovarian cancer (EOC). METHODSThis study is a meta-analysis of observational studies retrieved from the PubMed, EMBASE, and Web of Science databases prior to August 15, 2017. Two researchers independently screened studies and extracted study characteristics and risk estimates. The odds ratios (OR) and 95% confidence intervals (CI) of EOC risk were summarized using an inverse variance weighted randomeffects model. Heterogeneity between studies was assessed with the I 2 statistic. RESULTSEight case-control studies involving 7878 EOC cases and 73 913 controls were identified. Compared with non-use, use of antidepressants was not significantly associated with EOC risk (summarized OR = 1.10, 95% CI: 0.91-1.32, I 2 = 74.4%). Similar null results were also observed in the use of selective serotonin reuptake inhibitors (OR = 1.04, 95% CI = 0.80-1.35), tricyclic antidepressants (OR = 1.01, 95% CI = 0.79-1.30), and other antidepressant drugs (OR = 0.91, 95% CI = 0.74-1.12). Subgroup analyses of study characteristics, stratified by the type of control subjects, geographic location, exposure assessment, number of cases, and adjustment for potential confounders, showed that the ORs were broadly consistent across strata. The OR per 1 yearincrement of duration was 0.99 (95% CI = 0.94-1.05, I 2 = 40.0%, P = 0.154). Additionally, the OR for the greatest intensity of antidepressant use compared with never use was 0.82 (95% CI = 0.70-0.98, I 2 = 0%, P = 0.489). Furthermore, no evidence of publication bias was detected through Funnel plots as well as Egger's and Begg's tests. CONCLUSIONSThere is no association between antidepressant use and EOC risk. Further prospective studies are warranted to confirm these findings. British Journal of Clinical PharmacologyBr J Clin Pharmacol (2018) 84 649-658 649

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Section: Discussionmentioning

confidence: 99%

Association between antidepressant medication use and epithelial ovarian cancer risk: a systematic review and meta‐analysis of observational studies

Huo

Qiao

Gao

2018

Brit J Clinical Pharma

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“…However, the intrabursal application of norepinephrine and adrenergic agonists and antagonists in the ovary showed a significant increase in the number of new corpora lutea in prepuberal rats primed with PMSG (Kannisto et al, 1985). It has also recently been reported that the ovary is unable to release the ovocyte when applying neurotoxin DSP4 intrabursa (Goldman et al, 1996).…”

Section: Innervation and Ovarian Functionmentioning

confidence: 98%

Role of the central and peripheral nervous system in the ovarian function

Aguado

2002

Microscopy Res & Technique

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This review attempts to give a comprehensive overview of ovarian innervation, considering the whole nervous system and its different levels that may modify the ovarian function. The connection between the ovary and the central nervous system through the autonomic pathways, including the peripheral ganglia, is highlighted. The evidence obtained over the last years highlights the role of the superior ovarian nerve (SON) in the ovarian phenomena. Besides, the effect on the ovary of conventional neurotransmitters and others such as indolamines and peptides, which have been found in this organ, are discussed. Various reproductive diseases have been studied almost exclusively from the endocrine point of view. It is evident that a better knowledge about the role of the neural factors involved in the ovarian physiology may facilitate the understanding of some of these. A review of the concepts and an update of some experimental designs is made that permits clarifying several aspects of the relationship between the neural system and the ovary. At present, there is no doubt that the innervation of the ovary is involved in several physiological aspects of this gland function. However, the relationship of some levels of the nervous system and the ovary offer a wide avenue for future research.

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“…In addition, when a unilateral denervation of the SON was assessed, a decrease in the number of follicles was observed in the denervated ovary and a compensation (observed as an increase in the number of follicles) was observed in the innervated ovary (Moran et al 2000). In addition, it has been demonstrated that the sympathetic innervation of follicles influences follicular maturation/growth (Mayerhofer et al 1997, Paredes et al 2011, steroidal secretion (Hernandez et al 1988, Barria et al 1993 and ovulation (Kannisto et al 1985). In fact, an increase in ovarian sympathetic activity is observed in rats with an oestradiol-induced polycystic ovary condition.…”

Section: Sympathetic Innervation and Ovarian Ageingmentioning

confidence: 99%

Ovarian function and reproductive senescence in the rat: role of ovarian sympathetic innervation

2017

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Successful reproduction is the result of a myriad interactions in which the ovary and the ovarian follicular reserve play a fundamental role. At present, women who delay maternity until after 30 years of age have a decreased fertility rate due to various causes, including damaged follicles and a reduction in the reserve pool of follicles. Therefore, the period just prior to menopause, also known as the subfertile period, is important. The possibility of modulating the follicular pool and the health of follicles during this period to improve fertility is worth exploring. We have developed an animal model to study the ovarian ageing process during this subfertile period to understand the mechanisms responsible for reproductive senescence. In the rat model, we have shown that the sympathetic nervous system participates in regulating the follicular development during ovarian ageing. This article reviews the existing evidence on the presence and functional role of sympathetic nerve activity in regulating the follicular development during ovarian ageing, with a focus on the subfertile period. Free Spanish abstract: A Spanish translation of this abstract is freely available at http://www.reproduction-online.org/content/153/2/ R59/suppl/DC1. Reproduction (2017) 153 R59-R68

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Involvement of local adrenergic receptors in the process of ovulation in gonadotrophin-primed immature rats

Cited by 36 publications

References 19 publications

Association between antidepressant medication use and epithelial ovarian cancer risk: a systematic review and meta‐analysis of observational studies

Association between antidepressant medication use and epithelial ovarian cancer risk: a systematic review and meta‐analysis of observational studies

Role of the central and peripheral nervous system in the ovarian function

Ovarian function and reproductive senescence in the rat: role of ovarian sympathetic innervation

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