Involvement of mannose receptor in the preventive effects of mannose in lipopolysaccharide-induced acute lung injury

Improvement of spinal non-viral IL-10gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain

“…D-mannose is a simple hexose sugar with a molecular weight of 180.2 and is known to: decrease inflammatory processes during wound healing [76], reduce oxidative bursts required during inflammation [106], suppress adjuvant-induced arthritis in a rat model [107], inhibit LPS-induced IL-1β, TNF-α decrease NF-kB/p65 critical for proinflammatory cytokine expression, and decrease leukocyte influx following intratracheal instillation of LPS, which is a model of sepsis-associated acute lung injury and respiratory distress syndrome [77,108]. …”

Cyptoporus polysaccharide prevents lipopolysaccharide-induced acute lung injury associated with down-regulating Toll-like receptor 2 expression

“…Mannose, one of main composition isolated from CP, has been demonstrated to impair NF-B signaling through mannose receptor, prevent TNF-␣ and IL-1␤ mRNA expressions, and decrease TNF-␣ and IL-1␤ protein levels in LPS-challenged mice (Xu et al, 2010). Besides, we suggested that the significant inhibition of CP in LPS-induced inflammatory cell accumulation in the lung might be resultant from the inhibition of chemotaxic effect provocated by TNF-␣ and IL-1␤.…”

High-throughput methods for screening liposome–macrophage cell interaction

“…Activation of the mannose receptor has previously been shown to have an anti-inflammatory effect with impaired NFκB activation (Chieppa et al, 2003, Xu et al, 2010. In this study, mannosylated liposomes reduced NFκB activation in differentiated THP-1 cells compared to non-mannosylated DOPC liposomes in a concentration-and mannosylated cholesterol linker length-dependent manner.…”

“…The MR is involved in a range of processes including the recognition and internalisation of both foreign and self-materials, antigen presentation and intracellular signalling (Gazi and Martinez-Pomares, 2009). Moreover, mannose receptor activation has been linked to the initiation of an anti-inflammatory immunosuppressive programme in cells (Chieppa et al, 2003) and impaired NFκB activation (Xu et al, 2010), thus arguing for the utility of targeting strategies aimed at binding the MR, such as mannosylated liposomes.…”