Involvement of matrix metalloproteinases (<scp>MMP</scp>‐3 and <scp>MMP</scp>‐9) in the pathogenesis of irinotecan‐induced oral mucositis

Al‐Azri, Abdul Rahman; Gibson, Rachel J.; Bowen, Joanne M.; Stringer, Andrea M.; Keefe, Dorothy; Logan, Richard M.

doi:10.1111/jop.12255

Cited by 31 publications

(33 citation statements)

References 37 publications

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“…[35]. Recent research has also shown elevated MMP-9 expression in the ventral surface of the tongue of tumour-bearing rats treated with chemotherapy [27]. These parallel earlier research showing a time dependent increase in both MMP-2 and MMP-9 in the jejunum following irinotecan administration [34].…”

supporting

confidence: 65%

“…Epithelial thickness was measured ten times across the width of the tissue section and an average determined [27]. All analysis was conducted in a blinded fashion.…”

mentioning

confidence: 99%

“…All analysis was conducted in a blinded fashion. Slides were scanned using a NanoZoomer (Hamamatsu, Japan) and analysed using = moderate staining and 3 = intense staining ( Figure 2) and was conducted in a blinded fashion [27]. In addition, the characteristics of tight junction staining, including membrane specificity and location, were assessed qualitatively.…”

mentioning

confidence: 99%

“…This change comes as no surprise given the vast amount of research showing a strong inflammatory component to alimentary toxicity [21,25,27,34]. However, few studies have assessed cytokine and MMP expression in the oral epithelium of patients receiving chemotherapy, with most research coming from preclinical animal models.…”

mentioning

confidence: 99%

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Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer

Wardill

Logan

Bowen

et al. 2015

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supporting

confidence: 65%

“…Epithelial thickness was measured ten times across the width of the tissue section and an average determined [27]. All analysis was conducted in a blinded fashion.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer

Wardill

Logan

Bowen

et al. 2015

Support Care Cancer

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“…Tumor invasion and metastasis markers. Tumor cells break through the extracellular matrix and basement membrane, which is an important step during the process of tumor invasion and metastasis (65). Many matrix metallo proteinases (MMPs) play significant roles in this process, including MMP-1, -2, -7, -9, -10, -12, -13, -14, -19, and -26 (66)(67)(68).…”

Section: Tumor Suppressor Markers (Antitumor Defense and Apoptosis)mentioning

confidence: 99%

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Peng

Wang

Quan

et al. 2016

International Journal of Oncology

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Abstract. Oral verrucous carcinoma (OVC) is a verrucous variant of oral squamous cell carcinoma (OSCC), which accounts for 2-12% of all oral carcinomas with a 5-year survival rate of only approximately 50%. Enormous effort has been dedicated to this cancer, and the past decades have witnessed significant advances in relevant diagnostic and therapeutic approaches. Currently, there exist three challenges from primary sub-fields of research and clinical practice of the cancer, namely multifactorial etiology, complex molecular mechanism, and deficient treatment. This study reviews the existing literature on the cancer, encompassing its etiology, clinical manifestations and pathology, molecular mechanism, diagnosis and differential diagnosis, and treatment. For improved treatment of OVC, multifactorial etiology analysis, incorporation of effective biomarkers for mechanism illustration, and integration of multidisciplinary modalities are expounded, in an attempt to resolve the challenges and to provide a useful guide for future research in the field.

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The Effect of Photobiomodulation on Nitrite and Inflammatory Activity in Radiotherapy‐Induced Oral Mucositis: A Randomized Clinical Trial

et al. 2020

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Background and Objectives: To investigate pro-and anti-inflammatory cytokines and nitrite salivary levels in patients with head and neck cancer receiving photobiomodulation therapy (PBMT) associated with a Preventive Oral Care Program (POCP), for prevention and control of oral mucositis (OM) during radiotherapy (RT) associated or not with chemotherapy protocol. Study Design/Materials and Methods: In this randomized double-blinded clinical trial, 48 patients were randomly assigned to two groups: PBMT (n = 25) and Control (n = 23). In the PBMT group, patients were submitted to PBMT associated with the POCP. In the Control group, patients were submitted only to the POCP. Saliva samples were collected in the 1st (baseline), 7th, 14th, 21st, and 30th sessions of RT, and the levels of interleukin-6 (IL-6), IL-8, IL-10, IL-12p70, IL-1β, and tumoral necrosis factor-α (TNF-α) were measured using the cytometric bead array. Nitrite levels were measured by colorimetric method. OM was assessed using the World Health Organization and the National Cancer Institute scales. Results: Patients in the PBMT group presented less severe OM. PBMT tended to stabilize nitrite concentration levels during the RT regimen. The IL-1β concentration was associated with higher OM scores. PBMT promoted an increase in IL-12p70, TNF-α, and IL-10 concentration. Conclusion: PBMT was effective in the prevention and control of severe OM, and its mechanism of action may be related to a better balance of inflammatory response that may favor injury control. Lasers Surg. Med.

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Involvement of matrix metalloproteinases (MMP‐3 and MMP‐9) in the pathogenesis of irinotecan‐induced oral mucositis

Cited by 31 publications

References 37 publications

Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer

Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

The Effect of Photobiomodulation on Nitrite and Inflammatory Activity in Radiotherapy‐Induced Oral Mucositis: A Randomized Clinical Trial

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