Involvement of mitochondrial dysfunction in hepatotoxicity induced by Ageratina adenophora in mice

Abstract

Ageratina adenophora is a noxious plant and it is known to cause acute asthma, diarrhea, depilation, and even death in livestock (Zhu et al., 2007; Wang et al., 2017). A. adenophora grows near roadsides and degraded land worldwide (He et al., 2015b). In the areas where it grows, A. adenophora is an invasive species that inhibits the growth of local plants and causes poisoning in animals that come in contact with it (Nie et al., 2012). In China, these plants can be found in Yunnan, Sichuan, Guizhou, Chongqing, and other southwestern areas (He et al., 2015a) and they have become a dominant species in these local regions. It threatens the native biodiversity and ecosystem in the invaded areas and causes serious economic losses (Wang et al., 2017). It has been reported that A. adenophora can grow in the northeast direc

Preparation of Novel Magnetic Sodium Alginate-Ferric(III) Gel Beads and Their Super-Efficient Removal of Direct Dyes from Water

“…In particular, azo dyes are one of the most widely used synthetic dyes, accounting for more than half of the total dyes. Under special conditions, azo dyes can decompose to produce a variety of carcinogenic aromatic amines, which may cause human diseases and cancer after activation [2][3][4][5][6][7]. Therefore, azo-dye wastewater must be treated innocuously before discharge.…”

Ageratina adenophora Disrupts the Intestinal Structure and Immune Barrier Integrity in Rats

“…A. adenophora ingestion leads to the secretion of pro-inflammatory cytokines, intracellular contents, and induces extensive inflammatory responses [ 7 , 63 ]. Our study showed that A. adenophora could promote intestinal inflammation, disrupt intestinal structure and integrity, and also reduce the efficiency of the intestinal immune barrier.…”

“…Recent studies have reported various toxic effects of A. adenophora on various organs in different animal models (such as cattle, horse, rodent, sheep, and goats) that ingested this plant [ 3 , 4 , 5 ]. Sun et al [ 6 ] reported that A. adenophora could cause liver toxicity in mice, whereas other reports indicated that A. adenophora could induced spleen toxicity in mice [ 7 ]. In goats, A. adenophora induced oxidative stress in renal cells and also caused G1 arrest in the kidney cells [ 8 ].…”

An Overview: The Toxicity of Ageratina adenophora on Animals and Its Possible Interventions

“…Increased levels of ROS are associated with various diseases, such as chronic inflammation [ 36 ], and this promotes the release of various pro-inflammatory factors [ 37 ]. A. adenophora was reported to cause pyroptosis in the spleen of mice at the dose of 10% and above [ 14 ]. Pyroptosis involves the inflammatory response of pro-inflammatory cytokines, such as caspase-1 activation and interleukin-1β (IL-1β) production [ 38 , 39 , 40 ].…”

“…A. adenophora caused a disorder in the arrangement and inhibited the activities of the splenocytes and immune cells in mice [ 13 ]. This shows that A. adenophora induces oxidative stress in the liver, thereby damaging it [ 14 ].…”