Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin

Yi, Long; Xu, He-Li; Feng, Jing; Zhan, Xia; Zhou, Li-Pan; Cui, Cun-Cang

doi:10.1016/j.physbeh.2010.10.008

Cited by 78 publications

(43 citation statements)

References 51 publications

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“…Valproate has been shown to alter circadian period (109) and acute valproate treatment of PER2:LUC bioluminescence experiments in skin fibroblasts yielded amplitude enhancement and induced phase-shifts, depending on the relative level of PER2:LUC protein expression (110). Previous mouse studies have also suggested antidepressive functions of NOB (111, 112) (Table 2). For example, NOB was found to improve mouse performance in forced swimming test and tail suspension tests, while pretreatments with drugs targeting monoaminergic systems disrupted the NOB effects (112).…”

Section: Mood Disorders and Aging As Potential Pathophysiological Tarmentioning

confidence: 67%

Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging

2017

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Normal physiological functions require a robust biological timer called the circadian clock. When clocks are dysregulated, misaligned, or dampened, pathological consequences ensue, leading to chronic diseases and accelerated aging. An emerging research area is the development of clock-targeting compounds that may serve as drug candidates to correct dysregulated rhythms and hence mitigate disease symptoms and age-related decline. In this review, we first present a concise view of the circadian oscillator, physiological networks, and regulatory mechanisms of circadian amplitude. Given a close association of circadian amplitude dampening and disease progression, clock-enhancing small molecules (CEMs) are of particular interest as candidate chronotherapeutics. A recent proof-of-principle study illustrated that the natural polymethoxylated flavonoid nobiletin directly targets the circadian oscillator and elicits robust metabolic improvements in mice. We describe mood disorders and aging as potential therapeutic targets of CEMs. Future studies of CEMs will shed important insight into the regulation and disease relevance of circadian clocks.

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Section: Mood Disorders and Aging As Potential Pathophysiological Tarmentioning

confidence: 67%

Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging

2017

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“…amara , also known as neroli oil, has been reported to have antianxiety effects by regulating 5-HT receptors in rats [9] and to have antidepressant effects through the monoaminergic system in mice [10]. Neroli oil has also been reported to have sedative, antianxiety, and antidepressant effects on mice [11].…”

Section: Introductionmentioning

confidence: 99%

Effects of Inhalation of Essential Oil of Citrus aurantium L. var. amara on Menopausal Symptoms, Stress, and Estrogen in Postmenopausal Women: A Randomized Controlled Trial

Choi

Kang

Lee

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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This study aimed to investigate the effects of inhalation of the essential oil of Citrus aurantium L. var. amara (neroli oil) on menopausal symptoms, stress, and estrogen in postmenopausal women. Sixty-three healthy postmenopausal women were randomized to inhale 0.1% or 0.5% neroli oil or almond oil (control) for 5 minutes twice daily for 5 days. Menopause-related symptoms, as determined by the Menopause-Specific Quality of Life Questionnaire (MENQOL); sexual desire visual analog scale (VAS); serum cortisol and estrogen concentrations, blood pressure, pulse, and stress VAS, were measured before and after inhalation. Compared with the control group, the two neroli oil groups showed significant improvements in the physical domain score of the MENQOL and in sexual desire. Systolic blood pressure was significantly lower in the group inhaling 0.5% neroli oil than in the control group. Compared with the control group, the two neroli oil groups showed significantly lower diastolic blood pressure and tended to improve pulse rate and serum cortisol and estrogen concentrations. These findings indicate that inhalation of neroli oil helps relieve menopausal symptoms, increase sexual desire, and reduce blood pressure in postmenopausal women. Neroli oil may have potential as an effective intervention to reduce stress and improve the endocrine system.

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“…Cyproheptadine therefore either 1) does not decrease motoneuron excitability in neonatal mice, 2) was not at a concentration high enough to produce an effect, or 3) decreased excitability but did not affect disease progression. We believe options 1 and 2 are unlikely because cyproheptadine has previously been shown to block the effects of 5-HT application on neonatal rat motoneurons in vitro (Wang and Dun 1990), and the doses for this study were chosen based on their ability to inhibit 5-HTmodulated effects in vivo (Kilic et al 2011;Semenova and Ticku 1992;Singh and Goel 2010;Yi et al 2011). We therefore believe that these cyproheptadine doses were sufficient to inhibit motoneuron excitability.…”

Section: Discussionmentioning

confidence: 99%

“…Each pup in the litter was given the same drug dose, and care was taken to minimize the disruption of the litter. These cyproheptadine concentrations were chosen because of their clinical relevance (Kilic et al 2011;Semenova and Ticku 1992;Singh and Goel 2010;Yi et al 2011).…”

Section: Drug Administrationmentioning

confidence: 99%

Effect of fluoxetine on disease progression in a mouse model of ALS

Koschnitzky

Quinlan

Lukas

et al. 2014

Journal of Neurophysiology

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Koschnitzky JE, Quinlan KA, Lukas TJ, Kajtaz E, Kocevar EJ, Mayers WF, Siddique T, Heckman CJ. Effect of fluoxetine on disease progression in a mouse model of ALS. J Neurophysiol 111: 2164-2176, 2014. First published March 5, 2014 doi:10.1152/jn.00425.2013.-Selective serotonin reuptake inhibitors (SSRIs) and other antidepressants are often prescribed to amyotrophic lateral sclerosis (ALS) patients; however, the impact of these prescriptions on ALS disease progression has not been systematically tested. To determine whether SSRIs impact disease progression, fluoxetine (Prozac, 5 or 10 mg/kg) was administered to mutant superoxide dismutase 1 (SOD1) mice during one of three age ranges: neonatal [postnatal day (P)5-11], adult presymptomatic (P30 to end stage), and adult symptomatic (P70 to end stage). Long-term adult fluoxetine treatment (started at either P30 or P70 and continuing until end stage) had no significant effect on disease progression. In contrast, neonatal fluoxetine treatment (P5-11) had two effects. First, all animals (mutant SOD1 G93A and control: nontransgenic and SOD1 WT ) receiving the highest dose (10 mg/kg) had a sustained decrease in weight from P30 onward. Second, the high-dose SOD1 G93A mice reached end stage ϳ8 days (ϳ6% decrease in life span) sooner than vehicle and low-dose animals because of an increased rate of motor impairment. Fluoxetine increases synaptic serotonin (5-HT) levels, which is known to increase spinal motoneuron excitability. We confirmed that 5-HT increases spinal motoneuron excitability during this neonatal time period and therefore hypothesized that antagonizing 5-HT receptors during the same time period would improve disease outcome. However, cyproheptadine (1 or 5 mg/kg), a 5-HT receptor antagonist, had no effect on disease progression. These results show that a brief period of antidepressant treatment during a critical time window (the transition from neonatal to juvenile states) can be detrimental in ALS mouse models. amyotrophic lateral sclerosis; motoneuron excitability; fluoxetine; Prozac; antidepressant

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Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin

Cited by 78 publications

References 51 publications

Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging

Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging

Effects of Inhalation of Essential Oil of Citrus aurantium L. var. amara on Menopausal Symptoms, Stress, and Estrogen in Postmenopausal Women: A Randomized Controlled Trial

Effect of fluoxetine on disease progression in a mouse model of ALS

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