2021
DOI: 10.1186/s12885-021-07865-x
|View full text |Cite
|
Sign up to set email alerts
|

Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma

Abstract: Background Activating Gαq signalling mutations are considered an early event in the development of uveal melanoma. Whereas most tumours harbour a mutation in GNAQ or GNA11, CYSLTR2 (encoding G-protein coupled receptor CysLT2R) forms a rare alternative. The role of wild-type CysLT2R in uveal melanoma remains unknown. Methods We performed a digital PCR-based molecular analysis of benign choroidal nevi and primary uveal melanomas. Publicly available b… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
34
0
1

Year Published

2021
2021
2025
2025

Publication Types

Select...
6
1

Relationship

2
5

Authors

Journals

citations
Cited by 24 publications
(37 citation statements)
references
References 37 publications
2
34
0
1
Order By: Relevance
“…As opposed to next generation sequencing, absolute quantification with digital PCR allows to detect small differences in clone fractions and is therefore able to differentiate between early events [26].…”
Section: Secondary Copy Number Alterations In Uveal Melanoma Developmentmentioning
confidence: 99%
See 3 more Smart Citations
“…As opposed to next generation sequencing, absolute quantification with digital PCR allows to detect small differences in clone fractions and is therefore able to differentiate between early events [26].…”
Section: Secondary Copy Number Alterations In Uveal Melanoma Developmentmentioning
confidence: 99%
“…The important role of Gαq signalling in the development of uveal melanoma has been further supported by the identification of recurrent mutations in PLCB4 (p.D630, encoding phospholipase C β4) and CYSLTR2 (p.L129Q, encodinga Gαq-coupled receptor) [ 20 , 21 ]. These mutations are typically found in GNAQ and GNA11 wild-type tumours and provide an alternative way to activate the Gαq signalling pathway [ 20 26 ] (Fig. 3 ).…”
Section: Introductionmentioning
confidence: 99%
See 2 more Smart Citations
“…Moreover, the ANG-2-expressing macrophages and T cells were equally distributed among the immune infiltrate in the tumor. Furthermore, we tried to determine which cell type expressed ANG-2 by looking at single cell RNA data from eight primary UM (GSE139829) [43,44]. However, ANG-2 was expressed in a very low fraction (0-3%) of the cells per tumor, which was too marginal to draw any definite conclusions regarding the origin of ANG-2.…”
Section: Association Between Ang-2 and Inflammationmentioning
confidence: 99%