Involvement of NADPH-oxidase enzyme in the nephroprotective effect of (−)-α-bisabolol on HK2 cells exposed to ischemia – Reoxygenation

Sampaio, Tiago Lima; Menezes, Ramon Róseo Paula Pessoa Bezerra de; Lima, Dânya Bandeira; Silva, Rose Anny Costa; Azevedo, Isabella Evelyn Prado de; Magalhães, Emanuel Paula; Marinho, Márcia Machado; Santos, Ricardo; Martins, Alice Maria Costa

doi:10.1016/j.ejphar.2019.04.044

Cited by 13 publications

(8 citation statements)

References 29 publications

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“…It showed the ability to lessen oxidative stress and delay the development of various disease complications by countering ROS production as in isoproterenol-induced myocardial infarction [68]. Moreover, (−)-α-bisabolol has exhibited in vivo and in vitro nephroprotective activity in kidney ischemic-reperfusion models in vivo, through the attenuation of functional alterations and reduction of lipid peroxidation and urinary kidney injury molecule-1 (uKIM-1) levels, which was associated with an improvement of GSH levels in male Wistar rats, and in vitro through enhancing cell viability and decreasing ROS production in Rhesus Monkey Kidney Epithelial Cells (LLC-MK2 cells) [69] and inhibiting NADPH oxidase enzyme activity in HK2 cells [70]. In addition, cinnamaldehyde inhibits ROS production in association with the up-regulation of the antioxidative enzyme heme-oxygenase 1 (HO-1).…”

Section: Discussionmentioning

confidence: 99%

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

et al. 2020

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This study aimed to describe the protective efficacy of Moringa oleifera ethanolic extract (MOEE) against the impact of cobalt chloride (CoCl2) exposure on the rat’s kidney. Fifty male rats were assigned to five equal groups: a control group, a MOEE-administered group (400 mg/kg body weight (bw), daily via gastric tube), a CoCl2-intoxicated group (300 mg/L, daily in drinking water), a protective group, and a therapeutic co-administered group that received MOEE prior to or following and concurrently with CoCl2, respectively. The antioxidant status indices (superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH)), oxidative stress markers (hydrogen peroxide (H2O2), 8-hydroxy-2-deoxyguanosine (8-OHdG), and malondialdehyde (MDA)), and inflammatory response markers (nitric oxide (NO), tumor necrosis factor (TNF-α), myeloperoxidase (MPO), and C-reactive protein (CRP)) were evaluated. The expression profiles of pro-inflammatory cytokines (nuclear factor-kappa B (NF-kB) and interleukin-6 (IL-6)) were also measured by real-time quantitative polymerase chain reaction (qRT-PCR). The results showed that CoCl2 exposure was associated with significant elevations of oxidative stress and inflammatory indices with reductions in the endogenous tissue antioxidants’ concentrations. Moreover, CoCl2 enhanced the activity of the NF-κB inflammatory-signaling pathway that plays a role in the associated inflammation of the kidney. MOEE ameliorated CoCl2-induced renal oxidative damage and inflammatory injury with the suppression of the mRNA expression pattern of pro-inflammatory cytokine-encoding genes. MOEE is more effective when it is administered with CoCl2 exposure as a prophylactic regimen. In conclusion, MOEE administration exhibited protective effects in counteracting CoCl2-induced renal injury in rats.

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Section: Discussionmentioning

confidence: 99%

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

et al. 2020

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“…This was further validated by measuring NADPH oxidase gene (NOX4) expression, which was reduced after α-Bisabolol treatment [ 119 ]. The nephroprotective role of α-Bisabolol requires more extensive research to provide additional evidence on the effectiveness of α-Bisabolol and the mechanistic modulations against kidney injury.…”

Section: α-Bisabolol and Nephroprotectionmentioning

confidence: 99%

Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol

et al. 2022

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α-Bisabolol is one of the important monocyclic sesquiterpenes, derived naturally from essential oils of many edible and ornamental plants. It was first obtained from Matricaria chamomilla, commonly known as chamomile or German chamomile. The available literature indicates that this plant along with other α-Bisabolol containing plants is popularly used in traditional medicine for potential health benefits and general wellbeing. Nutritional studies are indicative of the health benefits of α-Bisabolol. Numerous experimental studies demonstrated pharmacological properties of α-Bisabolol including anticancer, antinociceptive, neuroprotective, cardioprotective, and antimicrobial. This review aims to collectively present different pharmacological activities based on both in vitro and in vivo studies. In the present review using synoptic tables and figures, we comprehensively present that α-Bisabolol possesses therapeutic and protective activities, therefore, it can be used for potential health benefits based on pharmacological effects, underlying molecular mechanism, and favorable pharmaceutical properties. Based on the studies mostly performed in cell lines or animal models, it is evident that α-Bisabolol may be a promising nutraceutical and phytomedicine to target aberrant biological mechanisms which result in altered physiological processes and various ailments. Given the polypharmacological effects and pleiotropic properties, along with favorable pharmacokinetics, and dietary availability and safety, α-Bisabolol can be used as a dietary agent, nutraceutical or phytopharmaceutical agent or as an adjuvant with currently available modern medicines. The regulatory approval of this molecule for use as food additives, and in cosmetics and fragrance industry is also supportive of its human usage. Moreover, further studies are necessary to address pharmaceutical, pharmacological, and toxicological aspects before clinical or nutritional usage in humans. The pharmacological effects and biological actions opens up opportunities on the pharmacological basis of its use in future therapeutics.

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“…Depletion of GSH levels lead to an increase in oxidative stress and is directly associated with I/R injury [ 168 ]. A number of plants as shown in Table 1 were reported to increase the levels of GSH, thereby protecting kidney from ROS generated by I/R injury [ 27 , 111 , 118 , 120 , 122 ] ( Table 1 ), and were reported to increase the levels of GSH, SOD, and catalase [ 116 , 145 ], while some others have been found to increase GSH, GSH-Px, SOD, and catalase [ 152 ]. Thus, plants exhibited versatile mechanisms of protection.…”

Section: Mechanisms By Which Plants Ameliorated Renal I/r Injury-indu...mentioning

confidence: 99%

Plants with Therapeutic Potential for Ischemic Acute Kidney Injury: A Systematic Review

Ali

Sampaio

Khan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Acute kidney injury (AKI) is a complex condition which has an intricate pathology mostly involving hemodynamic, inflammatory, and direct toxic effects at the cellular level with high morbidity and mortality ratios. Renal ischemic reperfusion injury (RIRI) is the main factor responsible for AKI, most often observed in different types of shock, kidney transplantation, sepsis, and postoperative procedures. The RIRI-induced AKI is accompanied by increased reactive oxygen species generation together with the activation of various inflammatory pathways. In this context, plant-derived medicines have shown encouraging nephroprotective properties. Evidence provided in this systemic review leads to the conclusion that plant-derived extracts and compounds exhibit nephroprotective action against renal ischemic reperfusion induced-AKI by increasing endogenous antioxidants and decreasing anti-inflammatory cytokines. However, there is no defined biomarker or target which can be used for treating AKI completely. These plant-derived extracts and compounds are only tested in selected transgenic animal models. To develop the results obtained into a therapeutic entity, one should apply them in proper vertebrate multitransgenic animal models prior to further validation in humans.

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Involvement of NADPH-oxidase enzyme in the nephroprotective effect of (−)-α-bisabolol on HK2 cells exposed to ischemia – Reoxygenation

Cited by 13 publications

References 29 publications

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol

Plants with Therapeutic Potential for Ischemic Acute Kidney Injury: A Systematic Review

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