Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment

Shalabi, Sharif; Belayachi, Ali; Larrivée, Bruno

doi:10.3389/fimmu.2024.1284629

Cited by 7 publications

(3 citation statements)

References 281 publications

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“…The induction of angiogenesis by ECs promotes neurogenesis, as this nutrient supply is critical to neuron growth and proliferation [ 10 , 13 ]. The intimate relationship between angiogenesis and neurogenesis is particularly prominent following ischemic stroke [ 10 , 13 ] and within the TME [ 14 ]. Additionally, cerebral ECs have a neuroprotective function through the secretion of brain-derived neurotropic factor (BDNF) [ 10 ].…”

Section: Cells Of the Central Nervous Systemmentioning

confidence: 99%

Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments

Hovis,

Chandra,

Kejriwal

et al. 2024

IJMS

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Glioblastoma is a highly aggressive neoplasm and the most common primary malignant brain tumor. Endothelial tissue plays a critical role in glioblastoma growth and progression, facilitating angiogenesis, cellular communication, and tumorigenesis. In this review, we present an up-to-date and comprehensive summary of the role of endothelial cells in glioblastomas, along with an overview of recent developments in glioblastoma therapies and tumor endothelial marker identification.

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Section: Cells Of the Central Nervous Systemmentioning

confidence: 99%

Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments

Hovis,

Chandra,

Kejriwal

et al. 2024

IJMS

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“…More and more evidence is emerging suggesting the intricate interplay between neuronal-derived angiogenic signals and tumor angiogenesis and cancer microenvironment [149]. Netrin-1 was originally described as a secreted protein regulating axon guidance; however, its role is far more multifaceted.…”

Section: Protein Phosphatase 2a (Pp2a)mentioning

confidence: 99%

Role of Protein Phosphatases in Tumor Angiogenesis: Assessing PP1, PP2A, PP2B and PTPs Activity

Fonódi,

Nagy,

Boratkó

2024

IJMS

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Tumor angiogenesis, the formation of new blood vessels to support tumor growth and metastasis, is a complex process regulated by a multitude of signaling pathways. Dysregulation of signaling pathways involving protein kinases has been extensively studied, but the role of protein phosphatases in angiogenesis within the tumor microenvironment remains less explored. However, among angiogenic pathways, protein phosphatases play critical roles in modulating signaling cascades. This review provides a comprehensive overview of the involvement of protein phosphatases in tumor angiogenesis, highlighting their diverse functions and mechanisms of action. Protein phosphatases are key regulators of cellular signaling pathways by catalyzing the dephosphorylation of proteins, thereby modulating their activity and function. This review aims to assess the activity of the protein tyrosine phosphatases and serine/threonine phosphatases. These phosphatases exert their effects on angiogenic signaling pathways through various mechanisms, including direct dephosphorylation of angiogenic receptors and downstream signaling molecules. Moreover, protein phosphatases also crosstalk with other signaling pathways involved in angiogenesis, further emphasizing their significance in regulating tumor vascularization, including endothelial cell survival, sprouting, and vessel maturation. In conclusion, this review underscores the pivotal role of protein phosphatases in tumor angiogenesis and accentuate their potential as therapeutic targets for anti-angiogenic therapy in cancer.

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“…Angiogenesis, the formation of new blood vessels from existing vasculature, is crucial in both healthy and diseased states ( 3 , 4 ). It has been firmly established that angiogenesis underpins tumor expansion and dissemination by supplying essential nutrients and oxygen, affirming its status as a fundamental characteristic of cancer and other diseases ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Elucidating the role of angiogenesis-related genes in colorectal cancer: a multi-omics analysis

Wei,

Xie,

Liu

et al. 2024

Front. Oncol.

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BackgroundAngiogenesis plays a pivotal role in colorectal cancer (CRC), yet its underlying mechanisms demand further exploration. This study aimed to elucidate the significance of angiogenesis-related genes (ARGs) in CRC through comprehensive multi-omics analysis.MethodsCRC patients were categorized according to ARGs expression to form angiogenesis-related clusters (ARCs). We investigated the correlation between ARCs and patient survival, clinical features, consensus molecular subtypes (CMS), cancer stem cell (CSC) index, tumor microenvironment (TME), gene mutations, and response to immunotherapy. Utilizing three machine learning algorithms (LASSO, Xgboost, and Decision Tree), we screen key ARGs associated with ARCs, further validated in independent cohorts. A prognostic signature based on key ARGs was developed and analyzed at the scRNA-seq level. Validation of gene expression in external cohorts, clinical tissues, and blood samples was conducted via RT-PCR assay.ResultsTwo distinct ARC subtypes were identified and were significantly associated with patient survival, clinical features, CMS, CSC index, and TME, but not with gene mutations. Four genes (S100A4, COL3A1, TIMP1, and APP) were identified as key ARCs, capable of distinguishing ARC subtypes. The prognostic signature based on these genes effectively stratified patients into high- or low-risk categories. scRNA-seq analysis showed that these genes were predominantly expressed in immune cells rather than in cancer cells. Validation in two external cohorts and through clinical samples confirmed significant expression differences between CRC and controls.ConclusionThis study identified two ARG subtypes in CRC and highlighted four key genes associated with these subtypes, offering new insights into personalized CRC treatment strategies.

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Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment

Cited by 7 publications

References 281 publications

Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments

Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments

Role of Protein Phosphatases in Tumor Angiogenesis: Assessing PP1, PP2A, PP2B and PTPs Activity

Elucidating the role of angiogenesis-related genes in colorectal cancer: a multi-omics analysis

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