Involvement of nicotinic acetylcholine receptors in the regulation of alcohol drinking in Wistar rats

Dyr, Wanda; Koroś, Eliza; Bieńkowski, Piotr; Kostowski, Wojciech

doi:10.1093/alcalc/34.1.43

Cited by 35 publications

(21 citation statements)

References 21 publications

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“…Moreover, Le and colleagues (2003), showed that nicotine-induced enhancement in ethanol operant selfadministration depended on the dose and time after the last nicotine injection. However, nicotine pre-treatment has also been associated with decreased operant self-administration of ethanol [36][37][38]. The reasons for these different results may be due to the nicotine withdrawal period, schedule of administration, or dose of nicotine.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Nicotine in Adult, but not Adolescent, Rats Increases Alcohol Self-Administration in Adulthood

P¹,

Cruz²,

Carneiro-de-Oliveira³

et al. 2017

J Alcohol Drug Depend

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Among drugs of abuse, nicotine and alcohol are the most consumed in the world, and are often co-abused. Evidence has shown that nicotine enhances the consumption and subjective effects of ethanol. How nicotine increases alcohol consumption is an interesting question that is still left unanswered. We assessed whether repeated treatment with nicotine during adolescence or adulthood could increase operant alcohol selfadministration. Male adolescent and adult rats (postnatal day [PND] 28 and 60, respectively) were injected with nicotine (1.0 mg/kg, subcutaneously [s.c.], three times a day for 10 days). During this period, the control group received saline injections (0.1 ml/kg; s.c). On PND 72, adolescent and adult rats pretreated with nicotine were subjected to ethanol self-administration procedures. Alcohol oral self-administration patterns were evaluated using a progressive ratio schedule of reinforcement and 24-hour unlimited access to ethanol. Our results showed that nicotine pretreatment in adult rats increases the motivation for alcohol consumption. However, nicotine exposure during adolescence does not affect alcohol-consuming behaviors in adulthood.

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Section: Discussionmentioning

confidence: 99%

Exposure to Nicotine in Adult, but not Adolescent, Rats Increases Alcohol Self-Administration in Adulthood

P¹,

Cruz²,

Carneiro-de-Oliveira³

et al. 2017

J Alcohol Drug Depend

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“…Alcohol has been reported to enhance the function of naturally expressed α4β2 nAChRs and to inhibit the activity of naturally expressed α7 nAChRs (Narahashi et al, 1999). Furthermore, activation of nAChRs was reported to selectively reduce alcohol consumption in outbred Wistar rats (Dyr et al, 1999), while mutations in transmembrane domains of α2 channel subunits can enhance actions of alcohols on neuronal nicotinic receptors (Borghese et al, 2002). …”

Section: Human Alcohol-responsive Mirnas Neurotransmitter Signalingmentioning

confidence: 99%

Understanding Alcoholism Through microRNA Signatures in Brains of Human Alcoholics

Nunez¹,

Mayfield²

2012

Front. Gene.

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Advances in the fields of genomics and genetics in the last decade have identified a large number of genes that can potentially influence alcohol-drinking behavior in humans as well as animal models. Consequently, the task of identifying efficient molecular targets that could be used to develop effective therapeutics against the disease has become increasingly daunting. One of the reasons for this is the fact that each of the many alcohol-responsive genes only contributes a small effect to the overall mechanism and disease phenotype, as is characteristic of complex traits. Current research trends are hence shifting toward the analysis of gene networks rather than emphasizing individual genes. The discovery of microRNAs and their mechanisms of action on regulation of transcript level and protein translation have made evident the utility of these small non-coding RNA molecules that act as central coordinators of multiple cross-communicating cellular pathways. Cells exploit the fact that a single microRNA can target hundreds of mRNA transcripts and that a single mRNA transcript can be simultaneously targeted by distinct microRNAs, to ensure fine-tuned and/or redundant control over a large number of cellular functions. By the same token, we can use these properties of microRNAs to develop novel, targeted strategies to combat complex disorders. In this review, we will focus on recent discoveries of microRNA signatures in brain of human alcoholics supporting the hypothesis that changes in gene expression and regulation by microRNAs are responsible for long-term neuroadaptations occurring during development of alcoholism. We also discuss insights into the potential modulation of epigenetic regulators by a subset of microRNAs. Taken together, microRNA activity may be controlling many of the cellular mechanisms already known to be involved in the development of alcoholism, and suggests potential targets for the development of novel therapeutic interventions.

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“…However, the results have been mixed, with studies also reporting that nicotine has no effect or even decreases ethanol self-administration [23–25]. We will review the evidence that nicotine increases ethanol self-administration by highlighting studies that use operant reinforcement to study the interaction.…”

Section: Introductionmentioning

confidence: 99%

Cigarettes and alcohol: The influence of nicotine on operant alcohol self-administration and the mesolimbic dopamine system

Ostroumov¹,

Thomas²,

Dani³

et al. 2015

Biochemical Pharmacology

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Studies in human populations consistently demonstrate an interaction between nicotine and ethanol use, each drug influencing the use of the other. Here we present data and review evidence from animal studies that nicotine influences operant self-administration of ethanol. The operant reinforcement paradigm has proven to be a behaviorally relevant and quantitative model for studying ethanol-seeking behavior. Exposure to nicotine can modify the reinforcing properties of ethanol during different phases of ethanol self-administration, including acquisition, maintenance, and reinstatement. Our data suggest that non-daily intermittent nicotine exposure can trigger a long-lasting increase in ethanol self-administration. The biological basis for interactions between nicotine and ethanol is not well understood but may involve the stress hormone systems and adaptations in the mesolimbic dopamine system. Future studies that combine operant self-administration with techniques for monitoring or manipulating in vivo neurophysiology may provide new insights into the neuronal mechanisms that link nicotine and alcohol use.

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Involvement of nicotinic acetylcholine receptors in the regulation of alcohol drinking in Wistar rats

Cited by 35 publications

References 21 publications

Exposure to Nicotine in Adult, but not Adolescent, Rats Increases Alcohol Self-Administration in Adulthood

Exposure to Nicotine in Adult, but not Adolescent, Rats Increases Alcohol Self-Administration in Adulthood

Understanding Alcoholism Through microRNA Signatures in Brains of Human Alcoholics

Cigarettes and alcohol: The influence of nicotine on operant alcohol self-administration and the mesolimbic dopamine system

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