Involvement of nitric oxide in the gastroprotective effects of an aqueous extract of Pfaffia glomerata (Spreng) Pedersen, Amaranthaceae, in rats

Freitas, Cristina Setim; Baggio, Cristiane Hatsuko; Silva-Santos, José Eduardo da; Rieck, Lia; Santos, Cid Aimbiré de Moraes; Júnior, Cirino Corrêa; Ming, Lin Chau; Cortez, Diógenes Aparı́cio Garcia; Marques, Maria Consuelo Andrade

doi:10.1016/j.lfs.2003.08.003

Cited by 56 publications

(52 citation statements)

References 28 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inhibition of these factors by acid inhibitory drugs (H 2 blockers and proton pump inhibitors) is one of the major components of current peptic ulcer therapy (Tarnawski et al, 1995 andRobinson, 2004). Previous studies reported an antiacid action of the AEP (Freitas et al, 2004), which could contribute for the healing process that this extract presented. In addition, the AEP may enhance the mucus and bicarbonate secretion which are important factors in the ulcer healing process, because the mucus/bicarbonate layer protects newly formed cells from acid and pepsin injury.…”

Section: Resultsmentioning

confidence: 99%

“…Besides, nitric oxide (NO) plays a role also in ulcer healing by stimulating the formation of growth factors, the epithelial proliferation and angiogenesis (Gyires, 2005). It was observed that AEP enhanced the NOx levels (Freitas et al, 2004) and then increased the blood flow and stimulated some events for the mucosal regeneration.…”

Section: Resultsmentioning

confidence: 99%

“…The yield of the lyophilized extract was 39%, relating to the dried subterraneous parts. The phytochemical characterization made through high performance liquid chromatography analyses (HPLC-DAD) revealed that P. glomerata contained around 0.37% of β-ecdysone, a marker of this plant (Freitas et al, 2004).…”

Section: Plant Materialsmentioning

confidence: 99%

“…A study done with the hydroalcoholic extract obtained from a mix of the roots from the distinct species of Pfaffia showed the protection of the gastric mucosa against ethanol-and stress-induced ulcers and reduction of the basal and bethanecholor histamine-stimulated gastric acid secretion (Freitas et al, 2003). Other study reported that the crude aqueous extract of Pfaffia glomerata (AEP) protected the gastric mucosa against ethanol-and stress-induced mucosal lesions and inhibited gastric acid secretion in the rats, probably through the inhibition of the histaminergic pathway and/or the enhancement of the gastric nitric oxide production (Freitas et al, 2004). The aim of this study was to evaluate the effects of the crude aqueous extract of P. glomerata (AEP) on the prevention of acetic acid induced ulcers and on the healing process on previously induced ulcers, besides the safety of its utilization by the population.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers

Freitas

Baggio

Araújo

et al. 2008

Braz. arch. biol. technol.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Plant Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers

Freitas

Baggio

Araújo

et al. 2008

Braz. arch. biol. technol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The IMD adds the points from evaluation of the color, the degree of edema and hemorrhage of the gastric folds, the number of pethechyae (l point = light; 2 points = moderated; 3 points = intense, for each parameter) and the points from the number and size of ulcers (number x size). Ranitidine-treated animals were used as positive control experiments (Freitas et al, 2004).…”

Section: Induction Of Acute Gastric Lesionmentioning

confidence: 99%

Gastroprotective effect of hydroalcoholic extract from barks of Persea major Kopp (Lauraceae) in rats

Cosmo¹,

Mayer²,

Freitas³

et al. 2007

Rev. bras. farmacogn.

View full text Add to dashboard Cite

RESUMO: "Efeito gastroprotetor do extrato hidroalcoólico da casca da Persea major Kopp (Lauraceae) em ratos". Persea major Kopp (Lauraceae) é utilizada na medicina tradicional para o tratamento de lesões cutâneas e distúrbios gástricos. O objetivo deste estudo é avaliar o potencial gastroprotetor e a toxicidade aguda do extrato bruto hidroalcóolico da Persea major Kopp (EHA). Camundongos Swiss foram tratados com EHA pelas vias oral (v.o.) e intraperitoneal (i.p.) com as doses de 0,125 a 10 g/kg e foram observados por 14 dias. A DL 50 calculada após administração i.p. de EHA foi de 480 mg/kg e superior a 10 g/kg pela via oral, em camundongos. Ratos Wistar foram pré-tratados oralmente com EHA (30, 100,300 e 1000 mg/kg) antes da indução de lesões gástricas por etanol 70% (0,5 mL/animal, v.o.), indometacina (20 mg/kg, s.c.) e estresse por contenção e hipotermia (durante 3 h a 4 ºC). O EHA protegeu a mucosa gástrica contra lesões induzidas por etanol, porém não protegeu contra as lesões induzidas por indometacina e estresse. Quando o EHA foi administrado pela via intraduodenal (i.d.), o volume, o pH e a acidez total da secreção gástrica de ratos com ligadura de piloro não foram alterados com diferentes doses do extrato. Os resultados obtidos sugerem um efeito citoprotetor contra ação necrosante direta do etanol pelo extrato bruto hidroalcoólico da Persea major e este efeito não está relacionado com a redução da secreção ácida gástrica. Unitermos: Persea major, Lauraceae, gastroprotetor, etanol.ABSTRACT: Persea major Kopp (Lauraceae) is used in folk medicine to treat skin wounds and gastric disorders. This study evaluates the potential of crude hydroalcoholic extract (EHA) as gastroprotective and its acute toxicity. Swiss mice were treated with EHA by oral (p.o.) and intraperitoneal (i.p.) routes with doses of 0.125 to 10 g/kg and were observed until 14 days after the administration of the extract. The calculated LD 50 of EHA after i.p. administration was 480 mg/kg in mice and the LD 50 values of EHA by the oral route were calculated to be up to 10 g/ kg in mice. Wistar rats were orally pretreated with EHA (30, 100, 300 and 1000 mg/kg) before induction of gastric lesions by 70% ethanol (0.5 mL/animal, p.o.), indomethacin (20 mg/kg, s.c.) and hypothermic restraint stress (during 3 h at 4 ºC). The EHA protected the gastric mucosa against lesions induced by ethanol, but did not reduce the stress-and indomethacin-induced gastric lesions. When the EHA was injected into the duodenal lumen (i.d.), the volume, pH and total acidity of the gastric secretion of rats with pylorus ligature was not altered with different doses of the extract. Results therefore suggest that the cytoprotective effect of this extract against the direct necrosing action of ethanol and its effect were not related with reduction of gastric acid secretion.

show abstract

Karyotype, genome size, and in vitro chromosome doubling of Pfaffia glomerata (Spreng.) Pedersen

Gomes

Saldanha

Neves

et al. 2014

Plant Cell Tiss Organ Cult

View full text Add to dashboard Cite

Involvement of nitric oxide in the gastroprotective effects of an aqueous extract of Pfaffia glomerata (Spreng) Pedersen, Amaranthaceae, in rats

Cited by 56 publications

References 28 publications

Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers

Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers

Gastroprotective effect of hydroalcoholic extract from barks of Persea major Kopp (Lauraceae) in rats

Karyotype, genome size, and in vitro chromosome doubling of Pfaffia glomerata (Spreng.) Pedersen

Contact Info

Product

Resources

About