2009
DOI: 10.1152/ajpheart.00043.2009
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Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat

Abstract: Endothelin (ET)-1 is a likely candidate for a key role in diabetic vascular complications. However, no abnormalities in the vascular responsiveness to ET-1 have been identified in the chronic stage of type 2 diabetes. Our goal was to look for abnormalities in the roles played by ET receptors (ET(A) and ET(B)) in the mesenteric artery of the type 2 diabetic Goto-Kakizaki (GK) rat and to identify the molecular mechanisms involved. Using mesenteric arteries from later-stage (32-38 wk old) individuals, we compared… Show more

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Cited by 47 publications
(57 citation statements)
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“…Exposure of RA (Fig. 1C) (43)(44)(45)(46). Indeed, Up 4 A-induced NO-dependent relaxation has been observed in rat aorta (41) and in rat perfused kidney (58).…”
Section: Resultsmentioning
confidence: 85%
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“…Exposure of RA (Fig. 1C) (43)(44)(45)(46). Indeed, Up 4 A-induced NO-dependent relaxation has been observed in rat aorta (41) and in rat perfused kidney (58).…”
Section: Resultsmentioning
confidence: 85%
“…5) and previous reports (19,20,43) suggest that the ERK pathway modulates contractile responses of vascular smooth muscle. As shown in Fig.…”
Section: Effect Of Up 4 a On Erk Activation In Ramentioning
confidence: 78%
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