Involvement of osteopontin, EpCAM, estrogen receptor-alpha, and carbonic anhydrase IX protein in managing lung cancer via Berberine-loaded liquid crystalline nanoparticles

De Rubis, Gabriele; Paudel, Keshav Raj; Allam, Venkata Sita Rama Raju; Malyla, Vamshikrishna; Subramaniyan, Vetriselvan; Singh, Sachin Kumar; Panth, Nisha; Gupta, Gaurav; Hansbro, Philip Michael; Chellappan, Dinesh Kumar; Dua, Kamal

doi:10.1016/j.prp.2023.154971

Pathology - Research and Practice

2024

DOI: 10.1016/j.prp.2023.154971

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Involvement of osteopontin, EpCAM, estrogen receptor-alpha, and carbonic anhydrase IX protein in managing lung cancer via Berberine-loaded liquid crystalline nanoparticles

Gabriele De Rubis,

Keshav Raj Paudel,

Venkata Sita Rama Raju Allam

et al.

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Cited by 7 publications

References 24 publications

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Berberine and berberine nanoformulations in cancer therapy: Focusing on lung cancer

Hsu,

Pallathadka,

Gupta

et al. 2024

Phytotherapy Research

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Lung cancer is the second most prevalent cancer and ranks first in cancer‐related death worldwide. Due to the resistance development to conventional cancer therapy strategies, including chemotherapy, radiotherapy, targeted therapy, and immunotherapy, various natural products and their extracts have been revealed as alternatives. Berberine (BBR), which is present in the stem, root, and bark of various trees, could exert anticancer activities by regulating tumor cell proliferation, apoptosis, autophagy, metastasis, angiogenesis, and immune responses via modulating several signaling pathways within the tumor microenvironment. Due to its poor water solubility, poor pharmacokinetics/bioavailability profile, and extensive p‐glycoprotein‐dependent efflux, BBR application in (pre) clinical studies is restricted. To overcome these limitations, BBR can be encapsulated in nanoparticle (NP)‐based drug delivery systems, as monotherapy or combinational therapy, and improve BBR therapeutic efficacy. Nanoformulations also facilitate the selective delivery of BBR into lung cancer cells. In addition to the anticancer activities of BBR, especially in lung cancer, here we reviewed the BBR nanoformulations, including polymeric NPs, metal‐based NPs, carbon nanostructures, and others, in the treatment of lung cancer.

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Berberine and berberine nanoformulations in cancer therapy: Focusing on lung cancer

Hsu,

Pallathadka,

Gupta

et al. 2024

Phytotherapy Research

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Liposomal encapsulated curcumin attenuates lung cancer proliferation, migration, and induces apoptosis

Kokkinis,

Paudel,

De Rubis

et al. 2024

Heliyon

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hsa_circ_0007755 competitively adsorbs miR-27b-3p to mediate CXCL2 expression and recruit Th1 cells to promote hypertrophic scars development

Qi,

Wu,

Liu

et al. 2024

Heliyon

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Involvement of osteopontin, EpCAM, estrogen receptor-alpha, and carbonic anhydrase IX protein in managing lung cancer via Berberine-loaded liquid crystalline nanoparticles

Cited by 7 publications

References 24 publications

Berberine and berberine nanoformulations in cancer therapy: Focusing on lung cancer

Berberine and berberine nanoformulations in cancer therapy: Focusing on lung cancer

Liposomal encapsulated curcumin attenuates lung cancer proliferation, migration, and induces apoptosis

hsa_circ_0007755 competitively adsorbs miR-27b-3p to mediate CXCL2 expression and recruit Th1 cells to promote hypertrophic scars development

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