Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery

Kenchegowda, Sachidananda; He, Jincai; Bazán, Haydee E. P.

doi:10.1016/j.plefa.2012.03.010

Cited by 27 publications

(17 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a lamellar keratectomy model that severs corneal nerves, NPD1 treatment markedly increased nerve regeneration [40, 41, 42], a bioaction that is consistent with the originally defined role of NPD1 as a neuroprotective SPM in the retina and in mouse models of stroke [6, 43]. …”

Section: Specialized Pro-resolving Mediators In Ocular Diseasessupporting

confidence: 55%

The role of pro-resolving lipid mediators in ocular diseases

Wei

Gronert

2017

Molecular Aspects of Medicine

View full text Add to dashboard Cite

Section: Specialized Pro-resolving Mediators In Ocular Diseasessupporting

confidence: 55%

The role of pro-resolving lipid mediators in ocular diseases

Wei

Gronert

2017

Molecular Aspects of Medicine

View full text Add to dashboard Cite

“…Our previous studies using a model of refractive surgery that damages the nerves at the stromal level have shown that the docosanoid neuroprotection D1 (NPD1) is synthetized in the cornea after treatment with PEDF+DHA and topical treatment with NPD1 increases nerve regeneration (Cortina et al, 2010; Cortina and Bazan, 2011; Cortina et al, 2013; Kenchegowda et al, 2013). Treatment with PEDF or DHA alone does not have a significant effect in corneal nerve regeneration (Cortina et al, 2010), demonstrating that the combination is necessary to synthetize NPD1 as well as possible other docosanoids.…”

Section: Discussionmentioning

confidence: 99%

PEDF plus DHA modulate inflammation and stimulate nerve regeneration after HSV-1 infection

Neumann

Kakazu

et al. 2017

Experimental Eye Research

View full text Add to dashboard Cite

Herpes simplex virus type-1 (HSV-1) infection leads to impaired corneal sensation and, in severe cases, to corneal ulceration, melting and perforation. Here, we explore the potential therapeutic action of pigment epithelial-derived factor (PEDF) plus docosahexaenoic acid (DHA) on corneal inflammation and nerve regeneration following HSV-1 infection. Rabbits inoculated with 100,000 PFU/eye of HSV-1 strain 17Syn+ were treated with PEDF+DHA or vehicle. PEDF+DHA treatment resulted in a biphasic immune response with stronger infiltration of CD4+T cells, neutrophils and macrophages at 7-days post-treatment (p.t.) that was significantly decreased by 14 days, compared to the vehicle-treated group. Screening of 14 immune-related genes by q-PCR showed that treatment induced higher expression of IFN-γ and CCL20 and inhibition of IL-18 by 7 days in the cornea. PEDF+DHA-treated animals developed less dendritic corneal lesions, opacity and neovascularization. Corneal nerve density increased at 12-weeks p.t. with functional recovery of corneal sensation. Treatment with PEDF+DHA that was postponed by 3 weeks also showed increased nerve density when compared to vehicle. Our data demonstrate that PEDF+DHA promotes resolution of the inflammatory response to the virus and, most importantly, induces regeneration of damaged corneal nerves vital for maintaining ocular surface homeostasis.

show abstract

“…In fact, diabetes resulted in reduced levels of n-3 PUFAs, by affecting n-3 fatty acid desaturase enzymatic activity, so that the provision of a DHA (22:6 n-3) enriched diet prevented dysfunction of rods and ameliorated vision (Yee et al, 2010). Also, n-3 PUFA derived NPD1, together with pigment epithelial-derived growth factor, promoted corneal nerve regeneration in a rat model of surgical injury (Cortina et al, 2010, 2012; Kenchegowda et al, 2013). However, other studies rather obtained contradictory results.…”

Section: Cellular Roles Of Fatty Acids In the Nervous Systemmentioning

confidence: 95%

Fatting the brain: a brief of recent research

Hussain¹,

Schmitt²,

Loeffler³

et al. 2013

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Fatty acids are of paramount importance to all cells, since they provide energy, function as signaling molecules, and sustain structural integrity of cellular membranes. In the nervous system, where fatty acids are found in huge amounts, they participate in its development and maintenance throughout life. Growing evidence strongly indicates that fatty acids in their own right are also implicated in pathological conditions, including neurodegenerative diseases, mental disorders, stroke, and trauma. In this review, we focus on recent studies that demonstrate the relationships between fatty acids and function and dysfunction of the nervous system. Fatty acids stimulate gene expression and neuronal activity, boost synaptogenesis and neurogenesis, and prevent neuroinflammation and apoptosis. By doing so, they promote brain development, ameliorate cognitive functions, serve as anti-depressants and anti-convulsants, bestow protection against traumatic insults, and enhance repairing processes. On the other hand, unbalance between different fatty acid families or excess of some of them generate deleterious side effects, which limit the translatability of successful results in experimental settings into effective therapeutic strategies for humans. Despite these constraints, there exists realistic evidence to consider that nutritional therapies based on fatty acids can be of benefit to several currently incurable nervous system diseases.

show abstract

Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery

Cited by 27 publications

References 51 publications

The role of pro-resolving lipid mediators in ocular diseases

The role of pro-resolving lipid mediators in ocular diseases

PEDF plus DHA modulate inflammation and stimulate nerve regeneration after HSV-1 infection

Fatting the brain: a brief of recent research

Contact Info

Product

Resources

About